Introduction: Cnidoscolus aconitifolius is considered to be an important and effective medicinal plant in folklore remedies where it has been applied as an alternative therapy for the treatment of various ailments. Aim: The present study aims to determine the effects of Cnidoscolus aconitifolius on lipid profile and some oxidative stress markers of male Wistar rats. Methodology: A total of 15 male wistar rats were procured for the study and randomly assigned into three groups of 5 rats each. Group 1 served as control and received distilled water only. Group 2 received 200 mg/kg and group 3 received 400mg/kg of the hydromethanolic (1:4) extract of Cnidoscolus aconitifolius which was administered as single daily dose using oral cannula. On completion of treatment, blood samples were collected by cardiac puncture for determination of some serum lipid parameters and oxidative stress markers. Results: Results showed that there were no significant difference in the serum level of total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol at both doses of the extract, compared to control. However, compared to control, there was a significant (p<0.05) increase in the activity of superoxide dismutase and glutathione reductase but significant reduction in malondialdehyde level. The catalase enzyme activity was not significant. Conclusion: The result obtained suggest that the extract may be useful in reducing oxidative stress by improving some antioxidant enzyme activities and may also prevent cell death due to lipid peroxidation.

This study was designed to evaluate the effect of hydro-methanol leaf extract of Eugenia uniflora on lead-induced reproductive toxicity in male Wistar rats. The male rats used for the study were divided into 5 groups of 6 animals each. Group I was the negative control group which received no treatment. Group II was the positive control which received 5 mg/kg BW Lead daily, while Group III received 5 mg/kg BW of Lead and 200mg/kg BW of extract., Group IV received 5 mg/kg BW of Lead and 400mg/kg BW of extract and group V received 5 mg/kg BW of Lead and 800mg/kg BW of extract. The administration was by oral gavage once daily for 30 days. At the end, animals were sacrificed under light chloroform anesthesia. Blood samples were collected into plain bottles for hormonal assay. The epidydimis was located with a small incision on the abdomen and semen sample was collected for analysis of sperm parameters. The data was analysed by applying one-way analysis of variance (ANOVA) using the SPSS version 23 software. Results of this study showed that extract of Eugenia uniflora significantly increased the level of serum testosterone and the percentages of viable sperm cells, sperm cells with normal morphology and actively motile sperm cells as well as, sperm count. The extract ameliorated lead induced reproductive toxicity. The result therefore, show that the extract improves sperm quality and quantity and protects the male reproductive function from the hazardous effect of environmental toxicants such as lead.

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Introduction Sexual health and function are inevitably, very important determinants of the quality of an individual's life (Suchita, et al.,2013).Sexual activity is universally recognized as essential component of a normal,healthy lifestyle and wellbeing (Singh, et al.,2013).However,the regular inability of a couple to indulge in a successful sexual intercourse is on the increase worldwide(Yakubu, etal.,2007).Reproduction in human begins with the copulation of a male and a female which results in fertilization(Fullick et al.,1994).For this process to be effective and satisfactory,the copulatory organ in the male,the penis and

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