Effects of coated copper sulphate and coated folic acid supplementation on growth, rumen fermentation and urinary excretion of purine derivatives in Holstein bulls

Wu, Qingmin; La, S.K.; Wang, C.; Zhang, J.; Liu, Q.; Guo, Gang; Huo, Weiguang; Pei, Caixia

doi:10.1016/j.anifeedsci.2021.114921

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…As discussed earlier, the possible reason for this might be the re ux of carbon towards the volatile fatty acid production from methane production. Also, there are reports of improvement in VFA concentration by the supplementation of copper, cobalt, and urea in the diet (Wu et al, 2021;Kišidayová et al, 2001;Schingoethe et al, 1976), which is in accordance with our study.…”

Section: Total Volatile Fatty Acidsupporting

confidence: 93%

Effect of copper and cobalt nanoparticles supplementation on methane emission and milk production in Gir cows fed with rice gruel diet

Shete,

Ramesh,

Karunakaran

et al. 2023

Preprint

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The feeding of rice gruel is common practice in India. The feeding of rice gruel causes metabolic diseases. The study was carried out to evaluate the effect of nanomineralson methane emission and milk production in Gir cows fed on rice gruel-based diet. All animals were divided into 3 groups. Animals were fed with cooked rice replaced in concentrate part of total diet. Parameters studied were feed intake, rumen fermentation pattern parameters (Ammonia nitrogen, methane emission, total volatile fatty acids, and microbial population), milk production, milk composition parameters (Fat, SNF, protein, total solids, total ash).The genes involved in the milk production and methanogenic bacterial population were also studied using real time PCR. The Ammonia nitrogen, total volatile fatty acids, milk production and bacterial count was found to be improved (p < 0.05) in both mega and nano mineral supplemented group. The feed intake was found to be decreased (p < 0.05) in nano mineral supplemented group. There was no significant difference in methane emission between the treatment, but the numerical reduction was observed in both mega and nano mineral supplemented groups. There was no significant difference (p < 0.05) in the milk composition and protozoal count.There was no significant difference (p < 0.05) among treatment groups for the CSN2 gene expression, even though inorganic and nano mineral supplemental group revealed numerically higher fold gene expression change for CSN2. The SLC2A8 gene was found to be upregulated (p < 0.05) in inorganic and nano mineral supplementation group compared to the control group.

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Section: Total Volatile Fatty Acidsupporting

confidence: 93%

Effect of copper and cobalt nanoparticles supplementation on methane emission and milk production in Gir cows fed with rice gruel diet

Shete,

Ramesh,

Karunakaran

et al. 2023

Preprint

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“…As a result, ruminants should be given a copper supplement with a lower rumen solubility than copper sulfate [13]. Wu et al [14] reported that the solubility of copper sulfate is approximately 100%, but coated copper sulfate released 24.3% of copper in the rumen and 59.6% of copper in the gut. According to Wang et al [15], the dietary supplementation of coated copper resulted in higher milk yield, apparent nutrient digestibility, rumen total VFA content and the quantity of fiber-digesting bacteria compared to those consuming CS-supplemented diets.…”

Section: Introductionmentioning

confidence: 99%

Effects of Copper Sulfate and Encapsulated Copper Addition on In Vitro Rumen Fermentation and Methane Production

Wilk

Pecka-Kiełb

Pastuszak³

et al. 2022

Agriculture

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Copper is a microelement crucial for the proper functioning of animals’ metabolic processes. The function of copper in rumen fermentation processes and methanogenesis is not well analyzed. The aim of the study was to evaluate the different types of copper supplement, their rumen decomposition and effect on in vitro ruminal fermentation as well as methanogenesis. Two different copper additives were used in the experiment: CS—copper sulfate (CuSO4 × 5 H2O)—and EC—encapsulated copper (tribasic copper chloride and copper sulfate enclosed within a polysaccharide polymer coating). A total mixed ration without copper additive was used as a control (C). In vitro rumen fermentation was conducted, and fermentation profile, gas production and methanogenesis were evaluated. After 24 h of fermentation, the amount of copper in the rumen fluid was significantly higher in the CS group. EC was protected against rumen degradation to a greater extent. The type of used copper supplement affects rumen fermentation. However, the effect on methanogenesis is ambiguous. CS supplement increases rumen gas production but does not affect methanogenesis. The obtained results suggest that the EC supplement may reduce the risk of low-fat milk and may improve the economic indicators of milk production. An in vivo experiment is necessary to compare the obtained in vitro results with animal productivity.

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“…Generally, the requirement of FA in ruminants can be met by producing the ruminal microflora (2). However, dietary supplements of FA higher than 0.5 mg/kg body weight improved animal performance and feed efficiency with increased serum folate concentrations and milk folate concentrations in most studies of ruminants (3,4). We recently found that the supplementation of rumen-protected FA in the maternal and/or lamb diets could increase the growth performance of lambs (5) and improve slaughter performance and meat quality (6).…”

Section: Introductionmentioning

confidence: 99%

Integrative network analysis revealed the molecular function of folic acid on immunological enhancement in a sheep model

Wang

et al. 2022

Front. Immunol.

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We previously observed the beneficial role of folic acid supplemented from maternal or offspring diet on lamb growth performance and immunity. Twenty-four Hu lambs from four groups (mother received folic acid or not, offspring received folic acid or not) were used in the current study, which was conducted consecutively to elucidate the molecular regulatory mechanisms of folic acid in lambs by analyzing blood metabolome, liver transcriptome, and muscle transcriptome. Serum metabolomics analysis showed that L-homocitrulline, hyodeoxycholic acid, 9-Hpode, palmitaldehyde, N-oleoyl glycine, hexadecanedioic acid, xylose, 1,7-dimethylxanthine, nicotinamide, acetyl-N-formyl-5-methoxykynurenamine, N6-succinyl adenosine, 11-cis-retinol, 18-hydroxycorticosterone, and 2-acetylfuran were down-regulated and methylisobutyrate was up-regulated by the feeding of folic acid from maternal and/or offspring diets. Meanwhile, folic acid increased the abundances of S100A12 and IRF6 but decreased TMEM25 in the liver. In the muscle, RBBP9, CALCR, PPP1R3D, UCP3, FBXL4, CMBL, and MTFR2 were up-regulated, CYP26B1 and MYH9 were down-regulated by the feeding of folic acid. The pathways of bile secretion, biosynthesis of unsaturated fatty acids, linoleic acid metabolism, and herpes simplex virus 1 infection were changed by folic acid in blood, liver, or muscle. Further integrated analysis revealed potential interactions among the liver, blood, and muscle, and the circulating metabolites, hub gene, and pathways, which might be the predominant acting targets of folic acid in animals. These findings provide fundamental information on the beneficial function of folic acid no matter from maternal or offspring, in regulating animal lipid metabolism and immune enhancement, providing a theoretical basis for the use of folic acid from the view of animal health care.

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Effects of coated copper sulphate and coated folic acid supplementation on growth, rumen fermentation and urinary excretion of purine derivatives in Holstein bulls

Cited by 7 publications

References 28 publications

Effect of copper and cobalt nanoparticles supplementation on methane emission and milk production in Gir cows fed with rice gruel diet

Effect of copper and cobalt nanoparticles supplementation on methane emission and milk production in Gir cows fed with rice gruel diet

Effects of Copper Sulfate and Encapsulated Copper Addition on In Vitro Rumen Fermentation and Methane Production

Integrative network analysis revealed the molecular function of folic acid on immunological enhancement in a sheep model

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