Effects of Cobalt on Physical and Mechanical Properties and In Vitro Degradation Behavior of Brushite Cement

Vahabzadeh, Sahar; Fleck, Sarah; Duvvuru, Murali Krishna; Cummings, Haley

doi:10.1007/s11837-018-3204-6

Cited by 8 publications

(6 citation statements)

References 28 publications

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“…The smaller size of Mg 2+ ions contracts the TCP crystal structure, stabilizes the β-TCP structure, and increases the phase transformation temperature of β-TCP to α-TCP 28. A similar stabilizing effect of β-TCP is also reported while using other trace elements [7,19,[28][29][30][31]. The formation of secondary phases depends on the synthesis method and Mg concentration.…”

Section: Discussionsupporting

confidence: 74%

Magnesium-Substituted Brushite Cement: Physical and Mechanical Properties

Fleck,

Vahabzadeh

2024

Crystals

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Brushite cements (BrCs) are calcium phosphate-based materials that are being widely used in hard tissue engineering applications due to their osteoconductivity, injectability, and bioresorbability. Therefore, the goal was to evaluate the effects of Mg concentration on the phase composition, setting time, and strength of BrC. Mg, which plays a vital role in bodily functions and bone health, was added to BrC at concentrations of 0.25, 0.50, 1.00, 1.50, 2.00, and 2.50 wt.%. The results showed that Mg stabilizes the TCP structure and increases the TCP content in final BrC. The initial and final setting times of BrCs increase with higher concentrations of Mg. Although 0.25 wt.% Mg did not change the setting of BrCs significantly, a higher concentration of 1.00 wt.% increased the initial setting time from 4.87 ± 0.38 min to 15.14 ± 0.88 min. Cements with Mg concentrations of 1.5 wt.% and above did not set after 4 h. Mg addition up to 0.5 wt.% did not change the compressive strength; however, higher concentrations decreased it significantly and 2.5 Mg-BrC had the lowest strength of 0.45 ± 0.09 MPs. Together, our results show that Mg can be added up to 1.00 wt.% without any adverse effect on the physical and mechanical properties of BrC.

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Section: Discussionsupporting

confidence: 74%

Magnesium-Substituted Brushite Cement: Physical and Mechanical Properties

Fleck,

Vahabzadeh

2024

Crystals

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“…Both effects were explained by the stabilization of the structure due to the full occupation of all Ca positions. Similar effects were described for incorporating smaller, divalent ions like Co 2+ [ 50 ]. They are supposed to stabilize the structure due to their smaller ionic radii, resulting in an increased setting time of brushite cements fabricated from β-TCP and MCPM.…”

Section: Resultsmentioning

confidence: 58%

“…Contrary, there are only few reports about accelerating effects of ions substituting Ca 2+ in β-TCP, as in the case of Co 2+ that slightly decreased IST and FST when added in minor amounts (0.25 wt%), while 1 wt% of Co 2+ increased both parameters. The decrease for lower Co 2+ amounts was attributed to the formation of the highly soluble CoHPO 4 [ 50 ]. An interesting observation was reported for Sr 2+ doped brushite cement: While both IST and FST increased up to Sr 2+ concentrations of 6.6 wt%, the setting times decreased again for higher concentrations (but were still above the values obtained for the reference).…”

Section: Resultsmentioning

confidence: 99%

Osteogenic lithium-doped brushite cements for bone regeneration

Hurle

Maia

Ribeiro

et al. 2022

Bioactive Materials

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“…The loaded metal ions can stabilize the crystalline water of brushite and prevent it from converting into monetite. 29,55,56 In a comparison of BCS, a small amount of unreacted MPCM was detected in ionloaded materials. Loading more ions on brushite will result in a surplus of MPCM during the setting process, which was also observed in the Cu-loaded brushite in other research.…”

Section: Discussionmentioning

confidence: 99%

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Li,

Ma,

et al. 2023

ACS Biomater. Sci. Eng.

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There is an urgent demand for antibacterial bone grafts in clinics. Worryingly, the misuse and overuse of antibiotics accelerate the emergence of drug-resistant bacteria. Therefore, this study prepared a novel injectable bioceramic cement without antibiotics (FS-BCS), which showed good antibacterial properties by loading iron and strontium onto a matrix composed of brushite and calcium sulfate. The setting time, injectability, microstructure, antibacterial properties, anti-biofilm properties, and cytocompatibility of the novel bioceramic cement were evaluated thoroughly. The results showed that the material was highly injectable and antiwashout. The antibacterial tests revealed that FS-BCS inhibited the growth of 99.9% E. coli and S. aureus separately in the broth due to the synergistic effect of strontium and iron. Simultaneously, crystal violet and fluorescent staining tests revealed that the material could significantly inhibit the formation of E. coli and S. aureus biofilms. In addition, the co-incorporation of iron and strontium promoted the proliferation and migration of osteoblasts. Therefore, FS-BCS has good application potential in antibiotic-free anti-infection bone grafting using minimally invasive surgery.

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Effects of Cobalt on Physical and Mechanical Properties and In Vitro Degradation Behavior of Brushite Cement

Cited by 8 publications

References 28 publications

Magnesium-Substituted Brushite Cement: Physical and Mechanical Properties

Magnesium-Substituted Brushite Cement: Physical and Mechanical Properties

Osteogenic lithium-doped brushite cements for bone regeneration

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

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