Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats

Abstract

PURPOSE:To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS:Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min. They were then resuscitated with: 1) saline 0.9%; 2) coconut water+3% NaCl;3) coconut water+NaCl 3%+simvastatin microemulsion (10 mg/kg i.v.; 4) normal coconut water. At 8h post-resuscitation, blood and lungs were collected for exams. RESULTS:Clinical scores, TNF-α, IL-1β, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. CONCLUSIONS:Resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.Key words: Shock, Hemorrhagic. Sepsis. Resuscitation. Simvastatin. Foods Containing Coconut. Rats. Effects of cococonut water and simvastatin in the treatment of sepsis and hemorrhagic shock in rats

Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats

“…In fact, the septic animals in the present study were clinically dehydrated and with weight loss 24 hours after sepsis induction. In this study the CLP sepsis model was used, following the technique of previous experimental reports 17,18 .…”