Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study

Kędziora–Kornatowska, Kornelia; Czuczejko, Jolanta; Motyl, Jadwiga; Szewczyk-Golec, Karolina; Kozakiewicz, Mariusz; Pawluk, Hanna; Kędziora, J; Błaszczak, Robert; Banach, Maciej; Rysz, Jacek

doi:10.5114/aoms.2010.14461

Cited by 28 publications

(13 citation statements)

References 35 publications

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“…The LDL carries cholesterol from the liver to the circulatory system. It is susceptible to oxidation by reactive oxygen species (ROS), and damage is seen both to the lipid and to the protein moiety [48, 49]. In an environment where oxidative stress is present and where there are lower levels of antioxidant HDL-C and higher levels of TG, oxidation of LDL might be more pronounced [50].…”

Section: Discussionmentioning

confidence: 99%

Lipid and protein oxidation in female patients with chronic fatigue syndrome

Tomić¹,

Brkić²,

Marić³

et al. 2012

aoms

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IntroductionChronic fatigue syndrome (CFS) is a widely recognized problem, characterized by prolonged, debilitating fatigue and a characteristic group of accompanying symptoms, that occurs four times more frequently in women than in men. The aim of the study was to determine the existence of oxidative stress and its possible consequences in female patients with CFS.Material and methodsTwenty-four women aged 15-45 who fulfilled the diagnostic criteria for CFS with no comorbidities were recruited and were age matched to a control group of 19 healthy women. After conducting the routine laboratory tests, levels of the lipid oxidation product malondialdehyde (MDA) and protein oxidation protein carbonyl (CO) were determined.ResultsThe CFS group had higher levels of triglycerides (p = 0.03), MDA (p = 0.03) and CO (p = 0.002) and lower levels of HDL cholesterol (p = 0.001) than the control group. There were no significant differences in the levels of total protein, total cholesterol or LDL cholesterol.ConclusionsThe CFS group had an unfavorable lipid profile and signs of oxidative stress induced damage to lipids and proteins. These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for atherosclerosis. Antioxidant treatment and life style changes are indicated for women with CFS, as well as closer observation in order to assess the degree of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Lipid and protein oxidation in female patients with chronic fatigue syndrome

Tomić¹,

Brkić²,

Marić³

et al. 2012

aoms

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show abstract

“…The patient groups were small and therefore some results could not reach or were bordering on statistical significance. Also we could not evaluate sex-dependent differences in both groups because of too few patients, especially in group C. Therefore further detailed studies based on a larger population are needed for a more comprehensive evaluation [28][29][30][31][32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Serum concentrations of adiponectin, leptin, resistin, ghrelin and insulin and their association with obesity indices in obese normo- and hypertensive patients – pilot study

Stępień¹,

Wlazeł²,

Paradowski³

et al. 2012

aoms

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A b s t r a c tIntroduction: Hypertension often coexists with obesity. Adipokines, ghrelin and insulin play important roles in the pathogenesis of both diseases. The aim of this study was to compare adiponectin, leptin, resistin, insulin and ghrelin mean serum concentrations and insulin resistance (HOMA-IR) in normo-and hypertensive patients with obesity. Material and methods: All included patients were divided on the following groups: non-diabetic hypertensive patients with class I obesity (group A, n = 21) and class II/III obesity (group B, n = 10), and normotensive obese (class I)patients (group C, n = 7). Correlations between obesity indices (body mass index [BMI], waist-tohip ratio [WHR], waist circumference [WC]), HOMA-IR, and hormone and adipokine serum levels were also analyzed. Results: Leptin level and HOMA-IR were significantly higher in group B compared to group C (9.74 ±3.88 ng/ml vs. 4.53 ±3.00 ng/ml; p < 0.02 and 3.30 ±1.59 vs. 1.65 ±0.41; p < 0.02, respectively). A negative correlation between WC and adiponectin level (R = -0.6275; p < 0.01) and a positive correlation between WC and insulin concentration (R = 0.5122; p < 0.05) as well as with HOMA-IR (R = 0.5228; p < 0.02) were found in group A. Negative correlations between BMI and ghrelin level (R = -0.7052; p < 0.05), WHR and adiponectin level (R = -0.6912; p < 0.05) and WHR and leptin level (R = -0.6728; p < 0.05) were observed in group B. Conclusions: Insulin resistance and leptin may be important pathogenic factors in hypertensive patients with severe obesity. Indices of abdominal obesity (WC, WHR) correlate better than BMI with HOMA-IR, insulin, adiponectin and leptin serum levels in hypertensive obese patients.

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“…The main EPO mechanism for the raising the hematocrit is an increase in RBC mass but a decrease plasma volume also occurs [87]. However, the link between hypertension and an increase in hematocrit has not be proven with certainty, and arterial hypertension may occur independently of EPO’s hematopoietic effect [88–90]. …”

Section: Epo and Hypertensionmentioning

confidence: 99%

Erythropoietin update 2011

et al. 2011

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SummaryTraditionally, erythropoietin (EPO) is described as a hematopoietic cytokine, regulating proliferation and differentiation and survival of the erythroid progenitors. The recent finding of new sites of EPO production and the wide spread distribution of EPO receptors (EPO-R) on endothelial cells, cardiomyocytes, renal cells as well as the central and peripheral nervous system raised the possibility that EPO may exert pleiotropic actions on several targets. Indeed studies (mainly preclinical) have documented protective, non-hematopoietic, abilities of EPO in a variety of tissue. However, the data obtained from clinical studies are more skeptical about these properties. This article provides a comprehensive overview of EPO and its derivatives.

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Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study

Cited by 28 publications

References 35 publications

Lipid and protein oxidation in female patients with chronic fatigue syndrome

Lipid and protein oxidation in female patients with chronic fatigue syndrome

Serum concentrations of adiponectin, leptin, resistin, ghrelin and insulin and their association with obesity indices in obese normo- and hypertensive patients – pilot study

Erythropoietin update 2011

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