Lipid and protein oxidation in female patients with chronic fatigue syndrome

Tomić, Slavica; Brkić, Snežana; Marić, D; Mikić, Aleksandra Novakov

doi:10.5114/aoms.2012.31620

Cited by 29 publications

(31 citation statements)

References 48 publications

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“…One study investigating fatigue in adult primary AITP highlighted the clinical importance of this symptom [43]. In accordance with the findings of this study, chronic fatigue syndrome (CFS) occurs four times more frequently in women than in men, with CFS patients demonstrating signs of OS [44]. We can confirm that these findings as patients with fatigue demonstrated significantly higher OS than patients without fatigue ( P = 0.0485).…”

Section: Discussionsupporting

confidence: 89%

Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Kamhieh-Milz

Salama

2014

Oxidative Medicine and Cellular Longevity

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As the involvement of oxidative stress (OS) in autoimmune thrombocytopenia (AITP) has been reported, a fast and rapid test for the reliable measurement of OS and antioxidant capacities (AOCs) might be a useful tool in extending current diagnostic possibilities. The free oxygen radical test (FORT) and free oxygen radical defence (FORD) assay (Callegari, Italy) are easy to perform and reliable, with results available within 15 minutes. Thirty-seven AITP patients and 37 matched healthy individuals were included in this study. All participants responded to a standard questionnaire provided by these assays. Female patients with AITP were observed to demonstrate significantly higher OS in comparison to female controls (P = 0.0027) and male AITP patients (P = 0.0018). The AOCs were not reduced in patients with AITP (P = 0.7648). Correlation of OS with platelet count identified a weak positive correlation (P = 0.0327, Spearman R = 0.4672). The questionnaire revealed that ITP patients in comparison to healthy controls are more stressed, feel exhausted and fatigued, and eat a healthier diet. In conclusion, OS is predominant in female but not in male patients with AITP suggesting gender-specific differences in the pathomechanisms of AITP. Identification of patients with high levels of OS might be beneficial in the management of AITP.

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Section: Discussionsupporting

confidence: 89%

Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Kamhieh-Milz

Salama

2014

Oxidative Medicine and Cellular Longevity

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“…It is the main product of lipid peroxidation induced by free radicals and can be found under physiological conditions in low concentrations. Most studies have shown that endurance exercise causes an increase in MDA [21], [22]. In this study, we found that pulse current could decrease the content of MDA, which indicates that pulse current can reduce the lipid peroxidation damage caused by free radicals, and thereby protect the integrity of the liver cell membrane.…”

Section: Discussionsupporting

confidence: 61%

Effects of Pulse Current on Endurance Exercise and Its Anti-Fatigue Properties in the Hepatic Tissue of Trained Rats

Cui¹,

Miao

Ju³

et al. 2013

PLoS ONE

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Fatigue is synonymous with a wide spectrum of familiar physiological conditions, from pathology and general health, to sport and physical exercise. Strenuous, prolonged exercise training causes fatigue. Although several studies have investigated the effects of electrical stimulation frequency on muscle fatigue, the effects of percutaneous pulse current stimulation on fatigue in the hepatic tissue of trained rats is still unclear. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of pulse current on endurance exercise and its anti-fatigue properties in exercised rats were studied. Rats were subjected to one, three or five weeks of swimming exercise training. After exercise training, rats in the treated group received daily applications of pulse current. All rats were sacrificed after one, three or five weeks of swimming exercise, and the major biochemical indexes were measured in serum and liver. The results demonstrate that pulse current could prolong the exhaustion swimming time, as well as decrease serum ALT, AST and LD levels and liver MDA content. It also elevated serum LDH activity, liver SOD activity and glycogen content. Furthermore, pulse current increased the expression of Bcl-2 and decreased the expression of Bax. Taken together, these results show that pulse current can elevate endurance capacity and facilitate recovery from fatigue.

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“…The present study also investigates the status of lipid peroxidation. Malondialdehyde(MDA ) is the product of lipid peroxidation and its level is a marker of lipid oxidation, also its content can reflect the degree of lipid peroxidation in vivo and indirectly reflect the extent of the damage of cells 28 . The results of the present experiments showed that SOD activity decreased significantly after acute exercise, in contrast, GSH content increased as well as DNA damage in mice blood cell.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Spirulina against Cell DNA Damage and Oxidative Stress Induced by Exhaustive Exercise

Su¹,

Zhang²,

Duoduo³

2013

Biomed. Pharmacol. J.

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The aim of the present study was to observe the effect of Spirulina supplementation on DNA damage in mice blood cell and blood redox status after acute exercise. 40 male Kunming mice was randomly assigned into four groups: Control group (CG), exercise group without Spirulina supplementation (EG), Spirulina supplementation group without exercise (SG) and Spirulina supplementation group with exercise (SEG). The exercise fatigue model was built up for mice through the protocol of repeated exhaustive treadmill running for seven days and the single cell gel electrophoresis (SCGE) was used to detect the DNA damage of blood cells in different groups. Blood samples were drawn from different groups and the changes of SOD and GSH which stand for anti-oxidative level in plasma. Also, Malondialdehyde (MDA), a marker of lipid peroxidation, was measured in the plasma of mice.This studies showed that the DNA damage of blood cell in SEG group was significantly lower than that of EG group (P<0.01) and there was no statical difference between CG and SG groups. And the level of GSH in SEG group were significantly lower than that of EG group (P<0.01).This results showed that plasma concentrations of malondialdehyde (MDA) were significantly decreased after supplementation with spirulina (P < 0.001). Those results leaded to conclusion that acute exercise induced more free radical to change the level of SOD, GSH and MDA and also occurred more DNA damage. It was suggested that DNA breakage occurs in blood cell after exhaustive exercise as a consequence of oxidative stress and the Spirulina supplementation has obvious protective effect to prevent exercise-induced DNA damage.

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Lipid and protein oxidation in female patients with chronic fatigue syndrome

Cited by 29 publications

References 48 publications

Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Effects of Pulse Current on Endurance Exercise and Its Anti-Fatigue Properties in the Hepatic Tissue of Trained Rats

Protective Effect of Spirulina against Cell DNA Damage and Oxidative Stress Induced by Exhaustive Exercise

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