Effects of combined estrogen/testosterone therapy on bone and body composition in oophorectomized women

Abstract

The addition of testosterone to oral estrogen might have positive effects on bone as suggested by the fact that it counteracted the decline in IGF-I and PICP levels. An anabolic effect on muscle was reflected by an increase in the total lean body mass. No adverse effects were noted on BMI, fat distribution or blood pressure during the 6-month treatment with oral testosterone undecanoate.

Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women

“…No change occurred in total and percent body fat as well as fat distribution in the three treatment regimens, which is in accordance with a recent study on treatment with TU combined with estrogen in postmenopausal women (43). Literature data on the effects of androgen or androgenϩestrogen treatment on body fat in women are contradicting because increased (16,18,20) as well as decreased (21) amounts of visceral body fat have been reported.…”

Testosterone addition to estrogen therapy – Effects on inflammatory markers for cardiovascular disease

“…The results on sexual function, well-being, lipids, bone and body composition have been published earlier [19][20][21]. The mean age was 54.0 + 2.9 years, mean BMI 25.7 + 2.8 kg/m 2 , and mean time since oophorectomy 4.6 + 2.4 years.…”

Androgen replacement therapy in women

“…TABLE 1 summarizes the randomized controlled studies on testosterone replacement in postmenopausal women with regard to their outcomes, including sexual function, mood, bone density, body composition and lipids . The main outcome in these studies is improvement in sexual function and wellbeing; comparing the different studies is challenging as study [55] ↑ total lean body mass ↑ sex quality parameters [56] (2) ERT + placebo No change in liver enzymes, lipids, endometrium and blood velocity [57] (2) ERT + placebo …”