2004
DOI: 10.1159/000075072
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Effects of Combined Nutritional Therapy on Acute Necrotizing Pancreatitis in Rats in the Early Phase of the Disease

Abstract: The aim of this study was to investigate the influence of a small amount of enteral nutrition along with parenteral nutrition on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats in the early phase of disease. The induction of ANP resulted in a significant increase in mortality rate, intestinal permeability, bacterial infection in the pancreas and extrapancreatic organs, pancreatic necrosis and serum activity of urea and amylase, and a significant decrease in concentrations of calci… Show more

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Cited by 2 publications
(4 citation statements)
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References 34 publications
(80 reference statements)
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“…The induction of ANP resulted in an increase of urinary excretion of PSP and translocation of bacteria in the study. Similar increased intestinal permeability in animals and human, along with an associated impaired gut barrier function, has also been reported during acute pancreatitis [21,24] . The use of 3FA improved intestinal permeability in this study.…”
Section: Discussionsupporting
confidence: 71%
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“…The induction of ANP resulted in an increase of urinary excretion of PSP and translocation of bacteria in the study. Similar increased intestinal permeability in animals and human, along with an associated impaired gut barrier function, has also been reported during acute pancreatitis [21,24] . The use of 3FA improved intestinal permeability in this study.…”
Section: Discussionsupporting
confidence: 71%
“…Various factors may be responsible for preventing translocation from the gastrointestinal tract: indigenous gastrointestinal, microflora preventing bacterial overgrowth, an intact intestinal epithelial barrier, normal mucosal and systemic host immunity, intestinal microcirculation, mucous and peristaltics [21,23] . Conditions such as trauma, burns, hemorrhagic shock, endotoxemia, malnutrition, TPN and enteral nutrition using elemental diets that disrupt or impair any of these protective mechanisms can lead to bacterial translocation into lymphatic and portal systems, and systemic circulation [21,23] .…”
Section: Discussionmentioning
confidence: 99%
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