Effects of combined β-hydroxy-β-methylbutyrate (HMB) and whey protein ingestion on symptoms of eccentric exercise-induced muscle damage

Abstract

BackgroundThe purpose of this study was to examine the effects of combined β-hydroxy-β-methylbutyrate (HMB) and whey protein ingestion on muscle strength and damage following a single bout of eccentric exercise.MethodsEighteen untrained male subjects were assigned to HMB and Whey protein (HMB + Whey; 3 g/day HMB and 36.6 g/day whey protein, n = 6), HMB (3 g/day, n = 6), or whey protein (36.6 g/day, n = 6) groups. Ingestion commenced 7 days before non-dominant elbow flexor eccentric exercise (30 deg/sec, 6 reps × 7 sets) and continued until 4 days post-exercise. The maximal isometric strength, muscle soreness, plasma creatine kinase (CK), lactate dehydrogenase (LDH) were assessed pre-exercise, and at 1, 2, 3, and 5 days after exercise.ResultsThe change scores of maximal isometric strength significantly decreased at day 1, 2, and 5 in the whey protein group compared to pre value and that in HMB + Whey protein and HMB groups decreased at day 1 and 5. The muscle soreness significantly increased in the whey and HMB + Whey protein groups at day 3 compared to pre value (p < 0.05). CK and LDH significantly increased (time effect: p < 0.05) after exercise. However, all data were not significant difference among the groups.ConclusionsThese results suggest that ingestion of combined HMB and whey protein does not have a role to inhibit muscle strength loss and soreness, and decrease in muscle damage markers after eccentric exercise in comparison with HMB and whey protein alone.

Combined protein and calcium β-hydroxy-β-methylbutyrate induced gains in leg fat free mass: a double-blinded, placebo-controlled study

“…In particular, it should be noted that the majority of previous strength training studies on HMB were rather short, lasting eight weeks or less. There is also increasing interest whether HMB supplementation can augment strength training-induced gains in FFM when a highprotein diet is provided [5,[20][21][22][23]. Recent studies suggest that protein balance is the critical driver for strength-training induced changes in muscle mass in resistance-trained men [20,22,23].…”

A2 Milk Enhances Dynamic Muscle Function Following Repeated Sprint Exercise, a Possible Ergogenic Aid for A1-Protein Intolerant Athletes?

“…Participation in unaccustomed eccentric exercise often causes exercise-induced muscle damage (EIMD) [ 1 , 2 , 3 ]. Physical activity with a large eccentric component includes resistance training, sprinting and plyometrics [ 4 ], all of which are common amongst sporting activities [ 5 ].…”

Suplementos nutricionales en el tratamiento y la prevención del dolor muscular tardío: una revisión sistemática (Nutritional supplements in the treatment and prevention of delayed muscle soreness onset: a systematic review)

“…El â-hidroxi-â-metilbutirato (âHâM) es un metabolito del aminoácido ramificado leucina que se produce a partir del cetoácido ácetoisocaproico (CIC) y debido a sus características metabólicas y baja toxicidad lo hacen un suplemento nutricional idóneo (Manjarrez, Torres-Vaca, González-Gallego, & Alvear-Ordenes, 2015). El âHâM ha sido utilizado como suplemento para contrarrestar el DMT, aunque los resultados no han sido concluyentes debido a que algunos reportan disminución del DMT ( Van-Someren, Edwards, & Howatson, 2005) también existen estudios donde no se han encontrado efectos positivos (Shirato et al, 2016). Sin embargo, en el primero de los casos se utilizó âHâM/CIC y en segundo âHâM y suero de leche aislado.…”