Effects of complex decongestive therapy and aquatic physiotherapy on markers of the inflammatory process in individuals with lymphedema

Pedrosa, Bruna Rafaele Vieira; Castro, Pedro Machado Manhães de; Santos, Luiza Vieira Santos e; Andrade, Danielly Lima de; Vilaça, Adriano Florencio; Júnior, José Eudes Gomes Pinheiro; Ferreira, Ana Paula de Lima; Lins, Esdras Marques; Maia, Juliana Netto; Andrade, Maria do Amparo; Castro, Célia Maria Machado Barbosa de

doi:10.1080/09593985.2022.2143252

Cited by 2 publications

(1 citation statement)

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“…In recent years, studies have shown that not only can CDT reduce accumulated fluid volume, but the act of encouraging lymph transport back to the central blood vascular circulation may also lead to anti-inflammatory changes at a molecular level. Recent studies have demonstrated that circulating levels of TNF-α, IL-10 and monocytes in lymphedema patients was significantly reduced following CDT when compared to control participants [115]. Other studies have investigated local hyaluronic acid clearance after CDT; the expression of this well-recognized fibrogenic factor is enhanced eightfold in lymphedematous tissues when compared to controls [131].…”

Section: Complete Decongestive Therapymentioning

confidence: 99%

The Role of Inflammation in Lymphedema: A Narrative Review of Pathogenesis and Opportunities for Therapeutic Intervention

Bowman,

Rockson

2024

IJMS

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Lymphedema is a chronic and progressive disease of the lymphatic system characterized by inflammation, increased adipose deposition, and tissue fibrosis. Despite early hypotheses identifying lymphedema as a disease of mechanical lymphatic disruption alone, the progressive inflammatory nature underlying this condition is now well-established. In this review, we provide an overview of the various inflammatory mechanisms that characterize lymphedema development and progression. These mechanisms contribute to the acute and chronic phases of lymphedema, which manifest clinically as inflammation, fibrosis, and adiposity. Furthermore, we highlight the interplay between current therapeutic modalities and the underlying inflammatory microenvironment, as well as opportunities for future therapeutic development.

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Section: Complete Decongestive Therapymentioning

confidence: 99%