An experimental study on Al alloy 7475‐T7351 was conducted to determine the influence of compressive loads on fatigue crack propagation. The investigation was based on the determination of the crack propagation stress intensity factor, KPR , under three different basic loading sequences involving compressive loads. The data of the entire experimental program collapse onto a single ‘master curve’ which describes KPR as a function of Kmax and the unloading ratio UR. Load interaction effects are mainly due to the changes of the residual compressive stress state in front of the crack tip, while crack closure plays a minor part. The results give an improved understanding of fatigue crack propagation.