Effects of Conjugated Linoleic Acid and Metformin on Insulin Sensitivity in Obese Children: Randomized Clinical Trial

Abstract

Improvement of insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp and IRS2 upregulation, favored patients treated with CLA.

<b><i>Euodia daniellii</i></b> Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes

“…Oleic acid [50,51] and linoleic acid [52,53] have been reported to have beneficial effects on metabolic disease. In the current study, we found that these fatty acids occupy more than half of BO (online suppl.…”

Metformin Therapy Reduces Obesity Indices in Children and Adolescents: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

“…All included studies were written in English and published between 2001 and 2017. Among these 38 included studies, 10 studies were done in Europe, 12,20,23,25,31,34,42,44,48,49 20 in the United States and Canada, 10,17,18,21,22,24,29,30,33,35,36,[39][40][41]43,45,47,50,51 3 in Middle America, 11,27,28 1 in Africa (Egypt), 26 and the remaining 2 studies in Asia (Iran). 19,46 In addition, two studies were done among populations from different countries.…”

“…19,46 In addition, two studies were done among populations from different countries. 32,37 Out of included studies, 12 studies were performed in children 17,25,27,28,31,32,39,40,42,[44][45][46]51 and 25 studies in adolescents. [10][11][12][18][19][20][21][22][23][24]26,29,30,[33][34][35][36][37][38]41,43,[47][48][49][50] In addition, six studies were conducted in female participants, 21,26,30,31,44,47 while the others recruited participants from both genders.…”

“…[10][11][12][18][19][20][21][22][23][24]26,29,30,[33][34][35][36][37][38]41,43,[47][48][49][50] In addition, six studies were conducted in female participants, 21,26,30,31,44,47 while the others recruited participants from both genders. [10][11][12][17][18][19][20][22][23][24][25][27][28][29][32][33][34][35][36][37][38]…”

“…[10][11][12][17][18][19][20][22][23][24][25][27][28][29][32][33][34][35][36][37][38][39][40][41][42][43]45,46,[48][49][50][51] Among in-cluded studies, one study had an open-label design. 42 Control groups received no intervention, 26,31,39,44 placebo, [10][11][12][17][18][19][20][21][22][23]25,[27][28][29][30]…”