Effects of copolymer component on the properties of phosphorylcholine micelles

Building Micelle Analog Nanoparticle for Multidrug Delivery: Dual‐Polymer Nanoparticles with Hydrophilic Shell and Double Hydrophobic Layers

“…When the amount of PLA is over 50%, the dissociated PLA from the micelles emerges in micellar preparation solution and the size of DPN almost maintains around 200 nm. The critical micelle concentration (CMC) value of DPN appears low, about 10 −3 mg mL −1 (Figure S1b, Supporting Information), which is similar to the value of the normal micelles of PCL‐ss‐PMPC . It also can be found that DPN can stably exist at 37.5 °C in 24 h with very few size change (Figure S1c, Supporting Information) but obvious size change under reduction condition (Figure S1d, Supporting Information), since the outer layer of DPN is a reduction‐sensitive amphiphilic polymer.…”

“…DPN and drug‐loaded DPN all appear negative zeta‐potential. Drug loading content (DLC) and drug loading efficiency (DLE) of DPN are higher than ordinary micelles . The DLC of DPN‐DI (DOX entrapped in inner layer together with PLA) is about 18.11%, which is higher than that of DPN‐DA (DOX in both PLA and PCL‐ss‐PMPC, 10.09%) and DPN‐DO (DOX in PCL‐ss‐PMPC, 7.76%).…”

“…DPN with hydrophilic shell and double hydrophobic layers was prepared though the method schematically represented in Figure . Hydrophobic polymer poly( l ‐lactide) (PLA) and amphiphilic polymer poly(ε‐caprolactone)‐ss‐ploy(phosphorylcholine) (PCL‐ss‐PMPC), which showed excellent property as drug delivery carriers in past report, were chosen as representatives of hydrophobic/amphiphilic polymers to prepare DPN. The structure of DPN is observed by transmission electron microscope (TEM) after staining by phosphotungstic acid ( Figure a).…”

“…The detailed process was as follows. Hydrophobic polymer PLA and amphiphilic polymer poly(ε‐caprolactone)‐ss‐ploy(phosphorylcholine) (PCL‐ss‐PMPC), which showed excellent property as drug delivery carriers in past report, were chosen as representatives of hydrophobic/amphiphilic polymers. PLA and PCL‐ss‐PMPC were severally dissolved in mixed solvent THF/CH 3 OH (2/1, v/v).…”

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)&ndash;polyethylene glycol&ndash;folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

“…[55][56][57][58] As mentioned, Dox as the model drug can be loaded in the hydrophobic region of PLGAbased nanoparticles through interactions, ie, physical encapsulation and electrostatic attraction. Dox LE/EE in PLGA and PLGA-PEG-FA were determined to be 8.2%/89.3% and 7.9%/85.8%, respectively (Table S2).…”