Effects of copper source and concentration on copper status and immune function in growing and finishing steers

Dorton, K. L.; Engle, T. E.; Hamar, Dwayne W.; Siciliano, P.D.; Yemm, R.

doi:10.1016/j.anifeedsci.2003.07.002

Cited by 35 publications

(28 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were observed in dairy steers in which, RBC -SOD activity increased in steers fed diet supplemented with 20 ppm Cu compared to copper deficient steers (Xin et al 1991). In contrast, Dorton et al (2003) reported no difference in RBC SOD activity for control and steers supplemented with 10 or 20 mg Cu/kg DM from organic or inorganic source. This enzyme also has been shown to be unresponsive to Cu supplementation compared to diamine oxidase activity in Cu status assessment study on human subjects (Kehoe et al 2000).…”

Section: Resultssupporting

confidence: 81%

“…Thus, research results with cattle are conflicting with respect to how Cu supplementation affects humoral immune response to a foreign antigen. In another experiment, Dorton et al (2003) reported higher antibody titer concentration to PRBC in cattle supplemented with copper from inorganic source compared to organic source. In accordance with present findings, the variations in antibody production with regard to sources (inorganic Vs organic) and with different antigens were not clear, but a possible explanation for variations in antibody production with antigens may be a difference in antigenicity of the antigens used in the experiments.…”

Section: Immune Responsementioning

confidence: 93%

“…From 14th day post sensitization, the total Ig concentration was higher (P<0.05) in lambs fed, 7 or 14 ppm Cu from organic source. Dorton et al (2003) reported higher (P<0.04) antibody titer specific for ovalbumin (OVA) in steers supplemented with 20 mg Cu/kg DM than steers supplemented with 10 mg Cu/kg DM and steers supplemented with 20 ppm Cu from organic source had greater (P<0.03) antibody titer concentration against OVA than from CuSO 4 . Salyer et al (2004) observed higher primary total antibody and IgG titers against OVA in CuSO 4 supplemented cattle than organic Cu supplemented cattle.…”

Section: Immune Responsementioning

confidence: 95%

“…Moreover, much higher dietary supplementation levels up to 30 ppm of Cu did not cause any observable toxicity in Ewes (Eckert et al 1999). Effect of Cu on immune response in cattle and other species are well documented (Spears 2000;Dorton et al 2003;Bartoskewitz et al 2007 andSolaiman et al 2007). But the information regarding the influence of copper on enzyme activity and immune response in sheep is sparse, in spite of their economic importance.…”

Section: Introductionmentioning

confidence: 90%

See 3 more Smart Citations

Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Senthilkumar

Nagalakshmi

Reddy

et al. 2008

Trop Anim Health Prod

View full text Add to dashboard Cite

An experiment was conducted on 30 male Nellore lambs with average body weight (BW) of 15.45 +/- 0.06 kg to determine the level of the copper (Cu) supplementation in diet from inorganic and organic sources required for optimum immunity and its effect on copper dependent enzymes by allotting them randomly to five groups in completely randomized design. The dietary treatments were viz., basal diet (no Cu supplementation, BD), other four groups were offered BD supplemented with 7 or 14 ppm Cu from copper sulphate (CuSO(4)) and Cu-proteinate, respectively. The lambs were fed the respective diets at 3.5 per cent BW to meet the requirements except Cu for 180 days. The humoral immune response against Brucella abortus and chicken RBC was assessed after 90 days of feeding. The in vivo delayed type hyper sensitivity reaction against PHA-P and in vitro lymphocyte proliferation against Con A indicative of cell mediated immune response (CMI) was assayed at 180 days of feeding. At the end of experiment four lambs from each group were slaughtered for estimation of liver superoxide dismutase activity (SOD). The ceruloplasmin and RBC-SOD activities were higher (P < 0.05) in 14 ppm Cu supplemented lambs from Cu-proteinate at 90 and 180 days, while the liver SOD activity was higher (P < 0.05) in lambs fed 14 ppm Cu from CuSO(4). The STAT titres against B. abortus were higher in Cu supplemented lambs, with no effect of dose of supplementation. Lambs supplemented with Cu-proteinate had higher titers than CuSO(4) on 7 and 14 days of post sensitization. The total immunoglobulin concentration and the CMI response against PHA-P and Con-A was higher (P < 0.05) in lambs fed 14 ppm Cu-proteinae diet. The IgM level was though high in Cu supplemented lambs, no dose or source effect were observed. The study indicated that Cu dependent enzymes activity and immune response were highest and respond better against stress in lambs on 14 ppm supplemented Cu from Cu-proteinate.

show abstract

Section: Resultssupporting

confidence: 81%

Section: Immune Responsementioning

confidence: 93%

Section: Immune Responsementioning

confidence: 95%

Section: Introductionmentioning

confidence: 90%

See 2 more Smart Citations

Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Senthilkumar

Nagalakshmi

Reddy

et al. 2008

Trop Anim Health Prod

View full text Add to dashboard Cite

show abstract

“…The effects of copper supplementation were reported in deficient dairy cows and calves using different levels and various form of copper with or without antagonists [8][9][10][11][12]. Similar studies were also performed in beef cattle [13][14][15][16][17][18][19]. However, limited information is available concerning to the effects of supplementation or over-supplementation of copper in non-deficient dairy calves in neonatal period along with decrease copper absorption due to rumen function.…”

Section: Discussionmentioning

confidence: 69%

Effects of Short-Term Over-supplementation of Copper in Milk on Hematology, Serum Proteins, Weight Gain, and Health in Dairy Calves

Naseri

Mohri

Aslani

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

Thirty-six calves were used in the present study. The animals were divided equally into three groups (control, test 1, and test 2). The three groups of calves were homogeneous for parity of dams, sex, and month of birth. From 14 days of age, in the test 1 group copper as copper sulfate (Merck Co, Germany) was added to each meal of milk at a rate of 10 mg/kg of milk for 14 days and in test 2 group copper as copper sulfate was added to each meal of milk at a rate of 20 mg/kg of milk for 14 days. Blood samples were taken by jugular venipuncture using disposable syringes at 14 (before Cu supplementation), 30, 60, and 80 days of age. Anticoagulated blood was used for CBC determination. Plane tubes were used for harvesting of serum and the amounts of total serum protein, albumin, iron, and copper were measured. Calves were weighted at birth and at the end of trial (day 80) and total gain and mean daily gain were calculated. Days of treatment for ill calves were also recorded during experiment. Group (treatment) had no significant effect on the amounts of measured parameters except MCH values (p < 0.05) which were significantly lower in test 1 group than other trial groups. Age (sampling time) had significant effects on the values of most measured parameters (p < 0.05) except WBC, lymphocyte, total protein, and fibrinogen. Significant interactions between sampling time and group were not seen for any of measured parameters. No significant differences were seen for total weight gain and mean daily gain between trial groups. Chi-square test revealed no significant difference for the days of treatment between trials groups.

show abstract

Synthesis, Characterization, Antibacterial and Photocatalytic Studies of Metal Oxides Coupled Nanocomposites

Ayyakannu Sundaram,

Murugesan,

Kanniah

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

In this study, we present a one‐pot synthetic approach for the preparation of metal oxide nanocomposites. Our investigation combines various analytical techniques, including FTIR, XRD, UV‐vis DRS, PL, XPS, SEM, EDX, and XANES, to comprehensively identify heterogeneous structures: SnO2‐CuO, CuO‐SnO2, NiO‐TiO2, and TiO2‐NiO. These metal oxide‐linked semiconductor solids serve as catalysts for dye photodegradation and exhibit remarkable biological activity. Our research is centered on exploring the photocatalytic potential of SnO2‐CuO nanocomposites while emphasizing the optimization of their photocatalytic and biological activities. This optimization is achieved through the careful incorporation of an ideal quantity of SnO2, as confirmed by EDX data, which reveals the composition as follows: O: 78.58 weight percent (0.525 keV), Cu: 12.61 weight percent (0.954 keV), and Sn: 8.81 weight percent (0.400 keV). Notably, under direct sunlight irradiation, the degradation efficiency of Rhodamine B dye surpasses that of pristine CuO, SnO2, TiO2, and NiO nanoparticles. Additionally, we explore the antimicrobial properties of these prepared samples at varying concentrations (50, 100, and 150 μl) against the pathogenic bacterium Staphylococcus aureus. Our findings highlight their effectiveness as antimicrobial agents. This research offers a promising method for developing highly active metal‐oxide‐linked nanomaterials, suitable for efficiently removing organic dye contaminants from water systems and showing great potential in antimicrobial applications.

show abstract

Effects of copper source and concentration on copper status and immune function in growing and finishing steers

Cited by 35 publications

References 75 publications

Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Effects of Short-Term Over-supplementation of Copper in Milk on Hematology, Serum Proteins, Weight Gain, and Health in Dairy Calves

Synthesis, Characterization, Antibacterial and Photocatalytic Studies of Metal Oxides Coupled Nanocomposites

Contact Info

Product

Resources

About