Effects of Coriandrum sativum L. in Association with Physical Exercise in Alloxan-Induced Type 1 Diabetes Mellitus in Rats

Abstract

Featured Application: The concomitant treatment proposed by this study could be an important therapeutic tool used to improve the complications arising from type 1 diabetes mellitus and could provide a clinical alternative for those individuals that currently only have the pharmacological path.Abstract: The treatment of type 1 diabetes mellitus (T1DM) is a health challenge and new approaches to solve this issue have been proposed. This study evaluated the biological effects of a concomitant treatment with Coriandrum sativum (coriander) and whole-body vibration (WBV) exercise on rats with T1DM. It is hypothesized that this concomitant treatment will improve the metabolic state of rats with T1DM. T1DM was induced with alloxan. Male rats (n = 20) were divided into four groups: control (CON), treated with coriander (COR), exposed to 50 Hz of WBV (WBV), and treated with coriander and exposed to 50 Hz of WBV (COR + WBV), weekly for 28 days. No alterations were observed in the metabolic outcome variables relating to the organs, specific biomarkers, body mass, food intake, and stool consistency. Alloxan-induced T1DM resisted desirable therapeutic effects of the proposed concomitant treatment as it inhibited antidiabetic activity of the coriander. Putting together all findings, neither coriander nor WBV exercise were capable of improving the metabolic state of the Wistar rats with T1DM. This data set and the knowledge in the literature about the effects of the concomitant treatment in healthy animals can provide greater reliability concerning the effects of coriander.