Effects of Cortisone on Acid, Pepsin, Sulfated Polysaccharides and Glycoprotein Secretion by the Mucosa of Denervated Fundic Pouches of Dogs

Abstract

The effects of acute and chronic administration of corticosteroïds were studied on the fundic secretion of 10 Heidenhain pouch dogs. Acid, pepsin and chondroïtin-4-sulfate secretion is increased during chronic administration. There is a latent time interval before these changes become apparent. Secretions of total and acidic glycoproteins from the visible mucus are increased during chronic but not after acute corticosteroïd treatment. The ability of the peptic and mucous cells to synthesize pepsin, chondroïtin-4-sulfate and glycoproteins isnot decreased but rather increased during prolonged cortisone treatment.

The Effect of ACTH and Cortisone on Gastric Acid Mucosubstances in Rats

“…However, these investigations of the in fluence of steroid hormones deal mainly with the effect of their prolonged administration. On the contrary, recent works indicate that steroids cause an increase of polysaccharides in the gastric mucosa [4,13,23]. The present results evidenced dissociated variations in fundus and antrum after steroid treatment.…”

“…Recent studies demonstrate that cellular effects of corticoid hormones differ considerably, depending on duration of application [5,14,20,21]. In addition, our earlier studies [10,11] and recent observations of otherauthors [4,13,23] showed an increase of some carbohydrate components in the gastric mucosa after treat ment with ACTH and cortisone. Therefore, in continuation of our investiga tions regarding the action of these hormones on the mucous cells of the stomach glands, we attempted to determine the changes in acid mucosub-…”

Histochemical and Histo-Autoradiographical Changes in Gastric Mucosa of Dogs Submitted to Chronical Cortisone Administration

“…Moreover, accuracy of our histochemical data, at least in the fundic mucosa, is clearly supported by the results of Bremen el al. [4] who observed a definite increase of acid glycoprotein and of chondroitin-4-sulfate secretion from Heidenhain pouches in cortisone treated dogs.…”