We now return to a discussion of "handedness"! Throughout this book we have used the terms right-handed and left-handed with an obvious connection to the right and left hands of human beings. We will now focus on the issue of preferred handedness in humans, rather than the use of these terms to simply indicate a particular mirror-image structure. The topic of handedness has been widely studied by psychologists, neuroscientists, biologists, physicians, and many others. This research topic is certainly one in which there are divided opinions, even on some of the most fundamental topics. As we will see, the issue of handedness is closely connected with the asymmetry of our brain, and the diagnostic tools of the twenty-first century have allowed scientists a much clearer view of the physical structure and biochemistry of our brain. In this chapter we shall attempt to present an accurate summary of the voluminous material available on this topic, and highlight the most recent research results.We should first acknowledge that there have been two very interesting and very detailed books written on this topic. In 1993