Effects of curculigoside A on random skin flap survival in rats

Chen, Tingxiang; Tu, Qiming; Cheng, Liang; Li, Zhijie; Lin, Dingsheng

doi:10.1016/j.ejphar.2018.07.030

Cited by 20 publications

(13 citation statements)

References 21 publications

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“…However, it is no doubt that the limitations of Sal B in the random skins therapy still need to be further investigated. For example, There are many active molecules and pharmaceuticals, such as VEGF(165), calcitriol, curculigoside A, have been shown to increase the survival of random pattern skin flaps in rats ( Giunta et al, 2005 ; Zhou et al, 2016 ; Chen et al, 2018 ). However, none of them have come to clinical application.…”

Section: Discussionmentioning

confidence: 99%

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

Lin

et al. 2018

Front. Pharmacol.

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Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. Sal B improved the survival area, reduced tissue edema, and increased the number of microvessels in skin flaps after 7 days, whereas an autophagy inhibitor (3-methyladenine) reversed the Sal B-induced increase in flap viability. In addition, Sal B stimulated angiogenesis, inhibited apoptosis, reduced oxidative stress, and upregulated autophagy in areas of ischemia. Moreover, the effects of Sal B on angiogenesis, apoptosis, and oxidative stress were reversed by autophagy inhibition. Overall, our findings suggest that Sal B has pro-angiogenesis, anti-apoptosis, and anti-oxidative stress effects by stimulating autophagy, which enhances the survival of random-pattern skin flaps.

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Section: Discussionmentioning

confidence: 99%

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

Lin

et al. 2018

Front. Pharmacol.

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“…Before surgery, animals were anesthetized by intraperitoneal injection of 2% (w/v) pentobarbital sodium 40 mg/kg. After that, the modified McFarlane flap model was performed in the rat dorsum (the same position in each rat): a caudal skin flap of 3×9 cm was incised and separated from subcutaneous deep fascia on the back of each rat, while pedicle of the flap was preserved 19–21. Followed by that sacral arteries were sectioned.…”

Section: Methodsmentioning

confidence: 99%

<p>Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress</p>

Lin¹,

Jia²,

Wang³

et al. 2019

DDDT

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Background: Random skin flap is frequently used in plastic and reconstructive surgery, but its distal part often occurs ischemia and necrosis. Pravastatin (Prava) with bioactivities of pro-angiogenesis, anti-apoptosis and anti-oxidative stress, may be beneficial for flap survival. Materials and methods: A modified McFarlane flap model was performed in Sprague-Dawley rats. The animals were divided into the Control and Prava groups and treated as follows: the Prava group was injected intraperitoneally with 2 mg/kg Prava for consecutive 7 days, and the Control group received an equal volume of vehicle daily. On day 7, the necrosis skin flaps were observed, while visualization of blood flow below the tissue surface was performed by Laser Doppler blood flow imaging (LDBFI). Then animals were euthanized, and levels of angiogenesis, apoptosis and oxidative stress were analyzed. Results: Prava decreased necrosis and edema of skin flaps compared with the Control group, with more blood flow in the flap under LDBFI. Prava treatment increased the mean vessels density, elevated the expression levels of angiogenic proteins (matrix metallopeptidase 9, vascular endothelial growth factor, Cadherin5) and antioxidant proteins (superoxide dismutase 1 (SOD1), endothelial nitric oxide synthase, heme oxygenase), and decreased the expression of apoptotic factors (BAX, CYC, Caspase3). In addition, malondialdehyde content was reduced, and glutathione level and SOD activity were increased in the skin flaps after treatment with Prava. Conclusion: Prava promotes survival of random skin flap through induction of angiogenesis, and inhibition of apoptosis and oxidative stress.

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“…Curculigoside A from the rhizome of C. orchioides improved the survival rate of random skin flaps in rats by inducing angiogenesis and alleviating ischemia-reperfusion (I/R) injury, increasing the VEGF and SOD expression and microvessel development and reducing the MDA level [ 98 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

Wang

2021

Molecules

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The genus Curculigo, as a folk herbal medicine, has been used for many years in China, treating impotence, limb limpness, and arthritis of the lumbar and knee joints. The last systematic review of the genus Curculigo was written in 2013, scientifically categorizing the phytochemistry and biological activities. Hitherto, the original compounds and their pharmacological activities were presented as the development of this genus, but there is not an updated review. To conclude the progression of the genus Curculigo, we collected the new literature published from 2013 to 2021 in PubMed, Web of Science, Google Scholar databases, and the Chinese National Knowledge Infrastructure. The novel chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides and polysaccharides were isolated from Curculigo. The new analyzing methods were established to control the quality of Curculigo as a herbal medicine. In addition, the pharmacological effects of Curculigo focused on anti-diabetes, antibacterial, anti-inflammatory, osteoporosis, antioxidation, etc. The antitumor and neuroprotective activities were newly explored in recent years. The application of herbal medicine was gradually developed in scientific methods. The medicinal value of the genus Curculigo needs to further investigate its pharmacological mechanisms. This new review offers more insights into the exploitation of the pharmacological value of the genus Curculigo.

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Effects of curculigoside A on random skin flap survival in rats

Cited by 20 publications

References 21 publications

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

<p>Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress</p>

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

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