Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans

Takahashi, Masaki; Suzuki, Katsuhiko; Kim, H. K.; Otsuka, Yohei; Imaizumi, Atsushi; Miyashita, Masashi; Sakamoto, Shizuo

doi:10.1055/s-0033-1357185

Cited by 79 publications

(98 citation statements)

References 17 publications

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“…We demonstrated that neutrophils firstly migrate to the damaged muscle, attract macrophages, and induce inflammatory mediators and cytokines [12]. Although curcumin is known to protect against ischemia/reperfusion injury in rat skeletal muscle [22], we demonstrated exercise-induced oxidative stress was attenuated by prior curcumin ingestion in vivo in humans [23]. Taheebo extract includes polyphenols that were found to suppress not only oxidative stress, but also the production of inflammatory cytokines and prostaglandin E2 by blocking cyclooxygenase-2 (COX-2) in the same manner as anti- …”

Section: Related and Supplementary Findingsmentioning

confidence: 84%

Exhaustive Exercise-Induced Neutrophil-Associated Tissue Damage and Possibility of its Prevention

Suzuki¹

2017

J Nanomedine Biotherapeutic Discov

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Neutrophils and inflammatory cytokines that accumulate in tissues often cause organ damage/dysfunctions. Herein, background information on some research findings of exertional effects on systemic inflammation centered on neutrophils is introduced. Furthermore, a functional activity measurement system of neutrophils including cell migration and reactive oxygen species (ROS) production, and preventive countermeasures against neutrophilinduced pathogenesis (e.g., polyphenols) are described.

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Section: Related and Supplementary Findingsmentioning

confidence: 84%

Exhaustive Exercise-Induced Neutrophil-Associated Tissue Damage and Possibility of its Prevention

Suzuki¹

2017

J Nanomedine Biotherapeutic Discov

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“…The levels of these enzymes improved after chronic Ex and antioxidant supplementation (grape seed extract). Takahashi et al27 reported that the serum biological antioxidant potential concentrations after Ex were much higher in single and double CW supplementation trials compared to those before Ex. CW supplementation can attenuate Ex-induced oxidative stress and increase blood’s antioxidant capacity.…”

Section: Discussionmentioning

confidence: 99%

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

Şahin¹,

Pala²,

Tuzcu

et al. 2016

JIR

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PurposeExercise (Ex) increases reactive oxygen species and impairs antioxidant defense systems. Recent data suggest that curcumin (CW) possesses peroxisome proliferator-activated receptor gamma activity and anti-inflammatory properties. Therefore, this study was designed to investigate the effects of CW supplementation on Ex performance, endurance, and changes in serum and muscle proteins in rats after exhaustive Ex.Materials and methodsTwenty-eight (28) male Wistar rats (age: 8 weeks and body weight: 180±20 g) were divided into four treatment groups: 1) control (C; no Ex), 2) C + CW (no Ex + CW), 3) C + Ex, and 4) C + Ex + CW (Ex + CW). CW was administered as 100 mg/kg CurcuWin®, providing 20 mg of curcuminoids daily for 6 weeks. A motor-driven rodent treadmill was used to carry out the Ex protocols. During a 5-day period, animals in chronic Ex groups were put through different regimens: day 1, 10 m/min for 10 minutes; day 2, 20 m/min for 10 minutes; day 3, 25 m/min for 10 minutes; day 4, 25 m/min for 20 minutes; and day 5, 25 m/min for 30 minutes. Animals were exercised at 25 m/min for 45 min/d for 5 d/wk for 6 weeks. Blood and muscle samples were analyzed for muscle markers, oxidative stress, and antioxidant markers.ResultsLactate and muscle malondialdehyde levels decreased in the CW-treated groups (P<0.0001). However, activities of antioxidant enzyme levels increased in the CW-treated groups. Run to exhaustion (minutes) improved in the CW-treated groups. Muscle nuclear factor-κB (P<0.05) and heat shock protein 70 (P<0.05) levels were much lowered in the CW treated group followed by Ex group. In addition, muscle inhibitors of kappa B, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, thioredoxin-1, sirtuin 1, nuclear factor (erythroid-derived 2)-like 2, and glucose transporter 4 protein levels in the Ex + CW group were higher than those in the control and Ex groups (P<0.05).ConclusionThis study suggests that novel CW has the potential to help prevent muscle damage by regulating the nuclear factor-κB and nuclear factor (erythroid-derived 2)-like 2 pathways and improve the performance and nutritional values of CW.

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“…Each participant underwent 2 laboratory-based trials in randomized order: (1) placebo (control), (2) between trials. Curcumin was provided by the Thera values Corporation design (Tokyo, Japan) (26). The product was developed to result in much higher plasma concentration and bioavailability after intake compared to conventional curcumin powder.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS)

Nakhostin-Roohi

Moradlou

Hamidabad

et al. 2016

Ann. Appl. Sport Sci.

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Inflammation and pain induced by delayed onset muscle soreness (DOMS) can be induced by eccentric exercise or an unaccustomed activity. The condition can causes problems in exercising and for athletes. The purpose of this study was to assess the effect of 150mg curcumin supplementation immediately after intensive eccentric exercise. Evaluations were made for total antioxidant Capacity (TAC), muscle damage markers, and DOMS induced pain. Ten healthy young males (age, 25.0 ± 1.6 years; height, 178.9 ± 4.1 cm; body mass, 81.1 ± 6.8 kg; fat%, 14.2 ± 2.1) completed a double blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (150mg) and a placebo on squat performance and DOMS following unaccustomed heavy eccentric exercise. Curcumin (CU) or placebo (P) was taken at the prescribed dose immediately after eccentric squat exercises; administrations were separated by a 14-day washout period. Measurements were made at the baseline, immediately, 24, 48, and 72h after exercise comprising: (a) limb pain (1-10 cm visual analogue scale; VAS), (b) total antioxidant capacity (TAC) (c) serum markers of muscle damage and inflammation. Measurements taken after exercise showed significantly reduced levels of pain, creatine kinase (CK), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in C group compared with group P group (P<0.05). TAC remained significantly high in group C after exercise compared with levels in group P (P<0.05). The findings of this study suggest that a 150mg dose of curcumin may have antioxidant, anti-inflammatory and analgesic effects on DOMS.

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Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans

Cited by 79 publications

References 17 publications

Exhaustive Exercise-Induced Neutrophil-Associated Tissue Damage and Possibility of its Prevention

Exhaustive Exercise-Induced Neutrophil-Associated Tissue Damage and Possibility of its Prevention

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS)

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