Effects of Curcuminoids on Frequency of Acute Myocardial Infarction After Coronary Artery Bypass Grafting

Wongcharoen, Wanwarang; Jai-aue, Sasivimon; Phrommintikul, Arintaya; Nawarawong, Weerachai; Woragidpoonpol, Surin; Tepsuwan, Thitipong; Sukonthasarn, Apichard; Apaijai, Nattayaporn; Chattipakorn, Nipon

doi:10.1016/j.amjcard.2012.02.043

Cited by 97 publications

(93 citation statements)

References 19 publications

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“…Previous studies have indicated that curcumin exerts cardioprotective effects in patients and animal models with acute or chronic myocardial infarction (3–6). In particular, a previous clinical study demonstrated that curcumin was able to decrease the incidence of in-hospital myocardial infarction from 30% (placebo) to 13.1% in the patients following coronary artery by decreasing C-reactive protein, malondialdehyde and N-terminal pro-B-type natriuretic peptide levels (3).…”

Section: Introductionmentioning

confidence: 99%

“…In particular, a previous clinical study demonstrated that curcumin was able to decrease the incidence of in-hospital myocardial infarction from 30% (placebo) to 13.1% in the patients following coronary artery by decreasing C-reactive protein, malondialdehyde and N-terminal pro-B-type natriuretic peptide levels (3). Animal studies have also demonstrated that curcumin promotes cardiac injury, limits myocardial infarction and improves cardiac function following acute and chronic myocardial ischemia (4–6).…”

Section: Introductionmentioning

confidence: 99%

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Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury

Yin

et al. 2016

Experimental and Therapeutic Medicine

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Curcumin is a natural polyphenol with powerful antioxidant and anti-inflammatory properties. The present study evaluated the protective effect of curcumin on myocardial injury in rats as well as the mechanisms underlying these effects, and examined the expression of nuclear factor-κB (NF-κB), peroxisome proliferator-activated receptor-γ (PPAR-γ) and B-cell leukemia/lymphoma-2 (Bcl-2) following myocardial infarction. A rat model of myocardial infarction was successfully established. Hematoxylin and eosin staining showed cellular atrophy and hyperchromatic cytoplasm in the myocardial infarction area. The myocardial cells displayed lysis and breakage of cardiac muscle fibers, karyopyknosis and karyorrhexis associated with infiltration of inflammatory cells and proliferation of fibrous tissue. Curcumin treatment at a dosage of 150 mg/kg/body weight resulted in an increase in surviving cells, fewer apoptotic cells, decreased proliferation of fibrous tissue and reduced infiltration of inflammatory cells, though necrosis was still present compared with the rats without curcumin treatment. The immunohistochemical assay demonstrated that curcumin treatment inhibited the expression of NF-κB, but increased the expression of PPAR-γ. The results of the reverse transcription-polymerase chain reaction indicated that curcumin treatment significantly increased the mRNA expression levels of Bcl-2 (P<0.01). Therefore, curcumin antagonizes cardiomyocyte apoptosis and inhibits inflammatory cell infiltration following myocardial infarction, which may be associated with its inhibitory effects on the expression of NF-κB, and activating effects on the expression of PPAR-γ and Bcl-2 in myocardial cells. Curcumin may be useful in clinical practice for saving more living heart muscle in the area of myocardial infarction and improving cardiac function following the elective opening of obstructed coronary arteries.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury

Yin

et al. 2016

Experimental and Therapeutic Medicine

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“…Curcumin protects the liver against injury and fibrogenesis caused by carbon tetrachloride in rats in part through suppression of inflammation [27]. Anti-inflammatory efficacy of oral curcumin has not been examined in human liver injury but has been recently investigated in the peri-operative period of coronary artery bypass graft, where it showed a significant reduction in in-hospital myocardial infarction as well as post-operative C-reactive protein levels [28]. TLR-7/9 antagonists, specifically the synthetic oligonucleotide IRS 954, has demonstrated great efficacy as a therapy in a murine model of acetaminophen-induced acute liver injury, reducing liver necrosis, hemorrhage, and inflammation [7].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic strategies in inflammasome mediated diseases of the liver

Hoque

Vodovotz

Mehal

2013

Journal of Hepatology

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Summary Tissue stress and cell death result in inflammation even in the absence of pathogens. Such sterile inflammation is dependent on a cytosolic complex of proteins inside immune cells termed the inflammasome. This complex converts two groups of extracellular signals into an inflammatory response via activation of caspase-1 and secretion of IL-1β and IL-18. Group 1 signals are typically TOLL like receptor agonists and result in transcriptional upregulation of inflammasome components and pro-cytokines. Group 2 signals are diverse, ranging from uric acid to ATP, and lead to assembly and activation of the inflammasome complex. Inflammasome components are required for a wide range of acute and chronic pathologies, including experimental alcoholic and non-alcoholic steatohepatitis, and drug-induced liver injury. Collectively, group 1 and 2 signals, inflammasome components, and cytokine receptors provide a rich source of therapeutic targets. Many of the advances in the field have come from standard reductionist experiments. Progress in the understanding of complex human systems will, however, be dependent on novel strategies such as systems analysis, which analyze large data sets to provide new insights.

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“…Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity [4]. It exhibits a great promise as a therapeutic agent, and is currently used in human clinical trials for a variety of conditions, including heart diseases [18].…”

Section: Introductionmentioning

confidence: 99%

“…Increased ROS are able to induce severe cardiovascular dysfunction by their direct attack on intercellular biomolecules such as contractile molecules or ion channels. Also, the imbalance of intracellular oxido-reductive state (redox) may lead to the activation of stress sensitive signalling pathways, increasing apoptosis and potentially contributing to the development of heart failure [18].…”

Section: Introductionmentioning

confidence: 99%

Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity

et al. 2015

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Effects of Curcuminoids on Frequency of Acute Myocardial Infarction After Coronary Artery Bypass Grafting

Cited by 97 publications

References 19 publications

Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury

Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury

Therapeutic strategies in inflammasome mediated diseases of the liver

Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity

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