Effects of cyanobacterium Fischerella ambigua isolates and cell free culture media on zebrafish (Danio rerio) embryo development

Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)

“…In recent years, there have been several studies to examine the toxic effect of MCs on the embryonic development and larval growth of aquatic organisms (Oberemm et al, 1997Wiegand et al, 1999;Liu et al, 2002;Wang et al, 2005;Wright et al, 2006;Malbrouck and Kestemont, 2006;Palı´kova´et al, 2007). Oberemm et al (1999) report that the early life stage of fish or amphibians may be more vulnerable to cyanobacterial toxins than juveniles or adults due to lower mobility to avoid contamination.…”

Mosquito Larvicides from Cyanobacteria

“…Many cyanobacteria derived metabolites have been evaluated using zebrafish assays (Berry et al, 2008 andWright et al, 2006). The assay has proven to be a useful tool in the purification of bioactive metabolites via bioassay guided fractionation (Berry et al, 2008).…”

Identification, Isolation, and Characterization of Developmental Toxins from the Cyanobacterium Fischerella 52-1 Using the Zebrafish (Danio rerio) Embryo Model

“…Other bioactive metabolites of Fischerella have been identified using the zebrafish embryo model (Wright et al, 2006). A study by Wright et al, (2006) showed that when zebrafish embryos were exposed to the culture medium of Fischerella ambigua, via ambient exposure, 100% mortality was observed, and when this extract was diluted the embryo development was significantly stunted which eventually caused embryo mortality.…”

“…A study by Wright et al, (2006) showed that when zebrafish embryos were exposed to the culture medium of Fischerella ambigua, via ambient exposure, 100% mortality was observed, and when this extract was diluted the embryo development was significantly stunted which eventually caused embryo mortality. Fractionation of the active medium identified Ambigol A and C, and a small amount of Tjipanazole D discussed in Chapter 1.…”

“…Using the zebrafish model, many bioactive metabolites from cyanobacteria have been evaluated and Wright et al, 2006. The zebrafish embryo model has many advantages that make it a useful tool in evaluating bioactivity of crude material and guiding the purification of bioactive metabolites .…”