Effects of cyclodextrins on the chemical stability of drugs

Popielec, Agnieszka; Loftsson, Þorsteinn

doi:10.1016/j.ijpharm.2017.06.009

Cited by 112 publications

(60 citation statements)

References 95 publications

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“…When designing a formulation employing CDs as stabilizers, it must be considered that the formation of an IC can make some drugs more stable but some others more labile. Furthermore, it has been observed that drugs that are stabilized in aqueous solution by a CD can be destabilized by the same CD in a solid dosage form [ 10 , 46 , 47 ]. Therefore, the use of CDs to improve the stability of a given drug or formulation must be thoroughly studied and the formulation carefully designed.…”

Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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We herein disclose how global cyclodextrin-based pharmaceutical technologies have evolved since the early 80s through a 1998 patents dataset retrieved from Derwent Innovation Index. We used text-mining techniques based on the patents semantic content to extract the knowledge contained therein, to analyze technologies related to the principal attributes of CDs: solubility, stability, and taste-masking enhancement. The majority of CDs pharmaceutical technologies are directed toward parenteral aqueous solutions. The development of oral and ocular formulations is rapidly growing, while technologies for nasal and pulmonary routes are emerging and seem to be promising. Formulations for topical, transdermal, vaginal, and rectal routes do not account for a high number of patents, but they may be hiding a great potential, representing opportunity research areas. Certainly, the progress in materials sciences, supramolecular chemistry, and nanotechnology, will influence the trend of that, apparently neglected, research. The bottom line, CDs pharmaceutical technologies are still increasing, and this trend is expected to continue in the coming years. Patent monitoring allows the identification of relevant technologies and trends to prioritize research, development, and investment in both, academia and industry. We expect the scope of this approach to be applied in the pharmaceutical field beyond CDs technological applications.

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Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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“…Moreover, CD systems identified in this work may be of additional value for diastereomers separation [ 11 ], solid-state chemical stabilization under certain conditions [ 7 ] and bitter taste masking [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…The interaction of APIs with CDs can be characterized by the stability constant K s [ 7 ], which is related to change of API solubility Δ S according to the formula:

where: S 0 —intrinsic solubility of API, K s —stability constant of API-CD system, [ CD ]—CD concentration. …”

Section: Introductionmentioning

confidence: 99%

Computer-Aided Discovery of New Solubility-Enhancing Drug Delivery System

et al. 2020

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The poor aqueous solubility of active pharmaceutical ingredients (APIs) places a limit on their therapeutic potential. Cyclodextrins (CDs) have been shown to improve the solubility of APIs, but the magnitude of the improvement depends on the structure of both the CDs and APIs. We have developed quantitative structure–property relationship (QSPR) models that predict the stability of the complexes formed by a popular poorly soluble antibiotic, cefuroxime axetil (CA) and different CDs. We applied this model to five CA–CD systems not included in the modeling set. Two out of three systems predicted to have poor stability and poor CA solubility, and both CA–CD systems predicted to have high stability and high CA solubility were confirmed experimentally. One of the CDs that significantly improved CA solubility, methyl-βCD, is described here for the first time, and we propose this CD as a novel promising excipient. Computational approaches and models developed and validated in this study could help accelerate the development of multifunctional CDs-based formulations.

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“…These properties, complemented with their non-toxicity to humans make these compounds very attractive for a wide range of industrial applications (Del Valle, 2004 ) involving, for example, food packaging (Astray et al, 2009 ; Sagiri et al, 2016 ), pharmaceutical technology (Loftsson and Brewster, 2010 ; Popielec and Loftsson, 2017 ), and catalytic processes (Li et al, 2012 ; Madhulika et al, 2016 ; Sebastien et al, 2016 ).…”

Section: Why Using Cellulose and Cyclodextrin Derivatives?mentioning

confidence: 99%

Combining Cellulose and Cyclodextrins: Fascinating Designs for Materials and Pharmaceutics

et al. 2018

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Cellulose and cyclodextrins possess unique properties that can be tailored, combined, and used in a considerable number of applications, including textiles, coatings, sensors, and drug delivery systems. Successfully structuring and applying cellulose and cyclodextrins conjugates requires a deep understanding of the relation between structural, and soft matter behavior, materials, energy, and function. This review focuses on the key advances in developing materials based on these conjugates. Relevant aspects regarding structural variations, methods of synthesis, processing and functionalization, and corresponding supramolecular properties are presented. The use of cellulose/cyclodextrin conjugates as intelligent platforms for applications in materials science and pharmaceutical technology is also outlined, focusing on drug delivery, textiles, and sensors.

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Effects of cyclodextrins on the chemical stability of drugs

Cited by 112 publications

References 95 publications

Technological evolution of cyclodextrins in the pharmaceutical field

Technological evolution of cyclodextrins in the pharmaceutical field

Computer-Aided Discovery of New Solubility-Enhancing Drug Delivery System

Combining Cellulose and Cyclodextrins: Fascinating Designs for Materials and Pharmaceutics

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