Effects of cyclosporin A and glucocorticosteroids on antigen-induced hypersensitivity to histamine in a guinea pig model of allergic rhinitis

Abstract

It is concluded that CyA and glucocorticosteroids suppress antigen-induced histamine hypersensitivity in a guinea pig model of allergic rhinitis.

Animal Models of Allergic Rhinitis

“…In allergic patients, the affinity and/or density of histamine H 1 receptors in nasal mucosa may be increased that could explain the nasal hypersensitivity of these patients to histamine. Nasal hyperreactivity to histamine has also been described in a guinea pig model of rhinitis [19]. The observation that in actively sensitized guinea pigs, an increased number of histamine H 1 receptors was found following antigen challenge could explain the nasal hyperreactivity to histamine [13].…”

Anti‐inflammatory effects of intranasal cyclosporine for allergic rhinitis in a mouse model

“…Mast cells play a key role in the early‐phase reaction of AR, which is characterized by sneezing, rhinorrhea, and itching due to the release of histamine, leukotrienes, and prostaglandins . In a previous study, systemic cyclosporine and corticosteroids suppressed antigen‐induced histamine hypersensitivity in an AR guinea pig model . Corticosteroid‐induced inhibition of IgE‐dependent release of histamine is a possible but unproven mode of action; corticosteroids are less effective than antihistamines in blocking early‐phase symptoms .…”

Pharmacological Effects of Novel Peptide Drugs on Allergic Rhinitis at the Small Ribonucleic Acids Level

“…Following widely reported rhinitis guinea pig model establishment protocol (Narita et al, 1998), we established a guinea pig model of AR using ovalbumin (OVA). OVA causes less irritation and fewer side effects than toluene diisocyanate but is prone to degeneration or coagulation and so must be made fresh immediately before use.…”