Effects of Cyproterone Acetate on the Adenohypophysial Cells of Male Rats

Lakshman, Arjun; Isaac, Peter G.

doi:10.1530/jrf.0.0320141

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…Only the progestational effect increases aggression. Opposed to this as aggression-reducing components are the antiandrogenic effect (Donald et al -1976), the androgen-dependent aggression-inducing pheromones (Nowel1et al -1969), the antigonadotropic effect (Donald et al -1976) and the decrease of ACTH (Neumann -1977) and STH (Laksman et al -1973). Gonadotropins, STH and ACTH can increase aggression (Matte, to be published).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cyproterone Acetate on Motor Activity, Aggression, “Emotionality”, Body Weight and Testes in Wild Mice

Matte

Fabian²

2009

Andrologia

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IntroductionCyproterone acetate (CA) has confirmed antiandrogenic, antigonadotropic and progestational effects (Neumann et al. -1971b, Neumann, -1977 and is employed in corresponding indications in human medicine (Neumann -1977;Schindler -1976). It is also a confirmed fact that androgens and gonadotropins can induce or increase aggressive behaviour in animals, while progesterone inhibits androgen activated intermale fighting in mice (Erpino et al. -1971; Luttge -1972). Major studies have failed to confirm a decrease of aggression under administration of CA (Brain et al. -1974; Brain et al. -1975; Brain et al. -1976; Edwards -1970; Sayler -1969). Agreement does, however, exist about a reduction of the sexual drive in man and animals (Neumann et al. -197 la) in addition to the decrease in the structure and function of the sex glands (Brain et al. -1974; Laksman -1973; Sayler -1969; Schreiber et al. -1971) with a reduction of spermatogenesis (Neumann -1977).According to general experience, a relationship exists between sexuality and aggression. This is also true in andrology and psychopathology. This experience is, however, confirmed only indirectly by the literature. CA reduces the gonadotropins (Donald et al. -1976), the administration of which increases aggressive behaviour (Matte, to be published), as well as the serum testosterone level (Donalds et al. -1976), which is closely connected with aggression. Although, besides the positive correlation between aggression and testosterone level (Gordon et al. -1976; Leshner et al. -1975; Rose et * Supported by Hamburgische Wissenschaftliche Stiftung, Joachim-JungiusGeselschaft der Wissenschaften e.V., and Universitatsgesellschaft Hamburg.

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Section: Discussionmentioning

confidence: 99%

The Effect of Cyproterone Acetate on Motor Activity, Aggression, “Emotionality”, Body Weight and Testes in Wild Mice

Matte

Fabian²

2009

Andrologia

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“…The PAS-Orange G-methyl blue staining technique showed that PAS-purple cells were more numerous than PAS-red cells. The former have been identified as delta-basiphils (FSH-cells) in both rats (Lakshman & Isaac, 1973) and gerbils (Kaul & Ramaswami, 1973). Treatment with a-chlorohydrin brought about remarkable changes in the delta-basiphils.…”

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Effects of -Chlorohydrin and Gonadectomy on the Adenohypophysial Cells of Male Rats and Gerbils

Dixit¹,

Lohiya²,

Hk³

1974

Reproduction

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Alpha-chlorohydrin (3-chlor-1,2 propanediol) possesses antifertility properties when administered to male rats, hamsters, guinea-pigs, rams and monkeys (Ericsson, 1968; Ericsson & Norland, 1970). The compound is thought to exert its action on the epididymis (Gunn, Gould & Anderson, 1969;Samojlik & Chang, 1970). Coppola (1969) andGunn et al. (1969) suggested that \ g = a \ \ x = r e q -\ chlorohydrin might act as a metabolic antagonist to glycerol in phospholipid metabolism and the compound has also been shown to act as an alkylating agent in vitro (Jones, Davies, Edwards & Jackson, 1969).The effects of \g=a\-chlorohydrin on the adenohypophysis have not so far been reported. The purpose of the present investigation was to compare the cytological changes occurring in the gonadotrophic cells of the anterior lobe of the pituitary in male rats and gerbils after the administration of \g=a\-chlorohydrin, with those changes following bilateral gonadectomy.The \g=a\-chlorohydrin(sp. gr. 1\m=.\326) was supplied by Upjohn Company, Kalamazoo, Michigan, in 0\m=.\25% aqueous ( 1\ m=. \ 3 g/ml) methylcellulose. A working solution was prepared by diluting the stock solution with distilled water.Thirty adult male gerbils (Meriones hurrianae) and thirty male rats were allotted to six groups of ten each. The drug was given orally, the gerbils receiving 20 mg/kg/day for 50 days and the rats, 25 mg/kg/day for 24 days. An equal number of controls received distilled water. The animals were killed 24 hr after administration of the final dose and various organs were removed, weighed and fixed. Pituitaries were fixed in Halmi's Susa (Susa: saturated picric acid, 9:1 v/v), processed, sectioned at 5 µ and stained with periodic acid Schiff (PAS)-orange G-methyl blue, and Cleveland-Wolfe trichromie stains. Differential cell counts were made in the sections stained with ClevelandWolfe trichromie stain.The investigations revealed that administration of -chlorohydrin to adult male gerbils and rats was associated with a decrease in the weights of the testes and accessory sex glands (Table 1 ) and inhibited spermatogenesis (unpublished observations). A significant decrease in thymus weight was also noted (gerbil, 36-6%; rat, 38-5%), but there was no significant influence on the adrenal and thyroid weights.Although the general structure of the normal rat pituitaries is well known, that of the gerbil is less familiar. The gland consists of three distinct parts : pars 185

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The role of sex hormones in the growth of antler bone tissue. I: Endocrine and metabolic effects of Antiandrogen therapy

Bubenik

Bubenik²,

Brown

et al. 1975

J. Exp. Zool.

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Cyproterone acetate (CA), an antiandrogenic compound, was used in order to investigate the role of testosterone in bone growth processes. The formation of Haversian systems in the growing antlers of white-tailed deer (Odocoileus virginianus) were substantially affected by only 3.5 mg of CA kg/wk. The mineralization processes of the bone matrix were almost completely blocked and the antlers persisted in growing throughout the whole year. Plasma levels of thyroxine, alkaline phosphatase and GH were higher while cortisol and testosterone levels were lower than in controls. No differences were registered in plasma levels of Ca, P or urea nitrogen. Despite hypertrophy of interstitial tissue, spermatogenesis was almost completely blocked. The sexual behaviour and the body appearance of experimental animals was typical for castrates.

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Effects of Cyproterone Acetate on the Adenohypophysial Cells of Male Rats

Cited by 10 publications

References 7 publications

The Effect of Cyproterone Acetate on Motor Activity, Aggression, “Emotionality”, Body Weight and Testes in Wild Mice

The Effect of Cyproterone Acetate on Motor Activity, Aggression, “Emotionality”, Body Weight and Testes in Wild Mice

Effects of -Chlorohydrin and Gonadectomy on the Adenohypophysial Cells of Male Rats and Gerbils

The role of sex hormones in the growth of antler bone tissue. I: Endocrine and metabolic effects of Antiandrogen therapy

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