Effects of D‐glucose, L‐glucose and D‐mannitol on renal calcium handling and general renal function in the rat

Abstract

SUMMARYStandard renal clearance techniques were used to compare the effects of D-glucose, L-glucose and D-mannitol on renal calcium handling and general renal function in the anaesthetized rat. A significant (P < 0 01) calciuresis was seen in animals infused with D-glucose. This resulted from a decreased tubular reabsorption of calcium. A similar response was not seen with Lglucose or D-mannitol. The contrasting actions of the three sugars on tubular calcium transport may relate to their different transport characteristics, since only D-glucose is actively reabsorbed. Responses of the three sugars also differed with respect to fractional fluid and sodium reabsorption which were significantly (P < 0-001) lower in animals infused with Lglucose and D-mannitol, and plasma insulin concentrations which were significantly (P < 0.01) elevated only in the D-glucose group. An unexpected finding was a highly significant (P < 0 001) and progressive fall in glomerular filtration rate (GFR) in animals infused with Lglucose. The reasons for this are not known.

Two-compartment model for determination of glycolytic rates of solid tumors byin vivo13C NMR spectroscopy

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