Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man

Székely, József I.; Török, Katalin; Karczag, I; Tolna, Judit; Till, Mária

doi:10.1007/bf02412112

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…Dihydrocodeine had no effect on a test of memory (the forward and backward digit span test) in healthy volunteers (Szekely et al, 1986). Furthermore, dihydrocodeine did not impair performance on a word fluency test (Guilford, 1967) that required participants to recall information from the distant past.…”

Section: Effects Of Opioids On Psychomotor and Cognitive Functioningmentioning

confidence: 94%

“…Szekely, Torok, Karczag, Tolna, and Till (1986) found that dihydrocodeine did not impair performance on a 5-min symbol-cancellation test (Le Toulouse, Vaschide, & Pieron, 1904) that is similar to the DSST. Participants were given dihydrocodeine and were then asked to cross out three target symbols in 29 lines of eight symbols.…”

Section: Effects Of Opioids On Psychomotor and Cognitive Functioningmentioning

confidence: 98%

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A review of the effects of opioids on psychomotor and cognitive functioning in humans.

Zacny¹

1995

Experimental and Clinical Psychopharmacology

179

112

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The literature on the effects of opioids on psychomotor and cognitive functioning in humans is evaluated. Some studies have examined the acute and chronic effects of various opioids on different subject populations. In addition, epidemiologic studies have examined the neuropsychological functioning and the risk of accidents for persons who have (or have had) opioids in their systemic circulation. In general, it appears that some opioids (mixed agonist–antagonists) more than others (morphine or codeine) impair psychomotor and cognitive functioning in healthy volunteers who have no history of opioid abuse. However, perhaps because of tolerance mechanisms, those who use opioids occasionally or habitually (patients with chronic pain or opioid abusers) are much less likely to have impairment of psychomotor or cognitive processes by opioids. Past research and present gaps in knowledge are used to make recommendations regarding worthwhile future directions in research.

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Section: Effects Of Opioids On Psychomotor and Cognitive Functioningmentioning

confidence: 94%

Section: Effects Of Opioids On Psychomotor and Cognitive Functioningmentioning

confidence: 98%

A review of the effects of opioids on psychomotor and cognitive functioning in humans.

Zacny¹

1995

Experimental and Clinical Psychopharmacology

179

112

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“…Across a wide variety of dosages and drugs, most studies did not observe an effect of opioid agonists and antagonists on working memory (see Table 3). Three studies did observe effect on working memory (Ghoneim, Mewaldt, & Thatcher, 1975;Martín del Campo, McMurray, Besser, & Grossman, 1992;Székely, Török, Karczag, Tolna, & Till, 1986). However, since these findings were in opposite directions and the studies used limited samples (8 or 10 males per study), it is difficult to draw firm conclusions about these results.…”

Section: Coding Taskmentioning

confidence: 95%

The role of the opioid system in decision making and cognitive control: A review

Steenbergen¹,

Eikemo²,

Leknes³

2018

Preprint

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The opioid system plays a key role in the regulation of affective processing including pain, pleasure, and reward. However, there is also increasing evidence that this system plays a broader role and can modulate cognitive function. In particular, increasing evidence suggests that the mu-opioid system influences how we choose between actions of different values and how we control our behavior in the face of distracting information. The present paper reviews the available evidence from studies that have used pharmacological manipulations of the mu-opioid system in healthy human volunteers. Our review covers experimental paradigms that have investigated reward-based decision making, impulsivity, neuropsychological tests of executive functioning, attention, inhibition and effort. The reviewed findings provide an emerging picture of how the mu-opioid system influences higher-level cognitive function via modulation of valuation, motivation and control circuits dense in mu-opioid receptors, including orbitofrontal cortex, basal ganglia, amygdalae, anterior cingulate cortex, and prefrontal cortex. The working model we put forward proposes that opioids influence decision making and cognitive control by increasing the subjective value of reward and reducing aversive arousal. The review highlights potential mechanisms that might underlie the effects of mu-opioids on decision making and cognitive control and provides important directions for future research.

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“…Interestingly, across a wide variety of doses and drugs in 16 studies, opioid agonists and antagonists typically do not affect working memory performance (Table 3). Three studies did observe effects on working memory (Ghoneim, Mewaldt, & Thatcher, 1975; Martín del Campo, McMurray, Besser, & Grossman, 1992; Székely, Török, Karczag, Tolna, & Till, 1986) but showed findings in opposite directions and had small study samples (8 or 10 males per study).…”

Section: Review Of Studies On Cognitive Controlmentioning

confidence: 99%

The role of the opioid system in decision making and cognitive control: A review

Steenbergen

Eikemo

Leknes

2019

Cogn Affect Behav Neurosci

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The opioid system regulates affective processing, including pain, pleasure, and reward. Restricting the role of this system to hedonic modulation may be an underestimation, however. Opioid receptors are distributed widely in the human brain, including the more Bcognitive^regions in the frontal and parietal lobes. Nonhuman animal research points to opioid modulation of cognitive and decision-making processes. We review emerging evidence on whether acute opioid drug modulation in healthy humans can influence cognitive function, such as how we choose between actions of different values and how we control our behavior in the face of distracting information. Specifically, we review studies employing opioid agonists or antagonists together with experimental paradigms of reward-based decision making, impulsivity, executive functioning, attention, inhibition, and effort. Although this field is still in its infancy, the emerging picture suggests that the mu-opioid system can influence higher-level cognitive function via modulation of valuation, motivation, and control circuits dense in mu-opioid receptors, including orbitofrontal cortex, basal ganglia, amygdalae, anterior cingulate cortex, and prefrontal cortex. The framework that we put forward proposes that opioids influence decision making and cognitive control by increasing the subjective value of reward and reducing aversive arousal. We highlight potential mechanisms that might underlie the effects of mu-opioid signaling on decision making and cognitive control and provide directions for future research.

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Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man

Cited by 5 publications

References 36 publications

A review of the effects of opioids on psychomotor and cognitive functioning in humans.

A review of the effects of opioids on psychomotor and cognitive functioning in humans.

The role of the opioid system in decision making and cognitive control: A review

The role of the opioid system in decision making and cognitive control: A review

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