Effects of daily environmental enrichment on behavior and dendritic spine density in hippocampus following neonatal hypoxia–ischemia in the rat

Rojas, Joseane Jiménez; Deniz, Bruna Ferrary; Miguel, Patrícia Maidana; Díaz, Ramiro Guedes; Hermel, Érica do Espírito-Santo; Achaval, Matilde; Netto, Carlos Alexandre; Pereira, Lenir Orlandi

doi:10.1016/j.expneurol.2012.11.026

Cited by 105 publications

(89 citation statements)

References 91 publications

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“…In support of this notion, exposure to enriched environment was effective in recovering declarative but not aversive memory impairment and preserved hippocampal dendritic spine density loss after neonatal HI injury in rats (Rojas et al, 2013). Environmental enrichment, however, did not affect HI-induced tissue atrophy in the hippocampus (Pereira et al, 2008).…”

Section: Accepted M Manuscriptmentioning

confidence: 63%

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Morán

Stokowska

Walker

et al. 2017

Experimental Neurology

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Pekna, M. (2017). Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic-ischemic brain injury. Experimental Neurology. DOI: 10.1016DOI: 10. /j.expneurol.2017 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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Section: Accepted M Manuscriptmentioning

confidence: 63%

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Morán

Stokowska

Walker

et al. 2017

Experimental Neurology

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“…The immature brain is highly receptive to environmental stimuli; indeed, even gentle handling of rat pups for 15 min per day following neonatal injury improves long-term spatial learning ability [76]. Notably, in a neonatal model of hypoxia-ischemia, EE improves object recognition and spatial memory [77,78], attributed in part to preservation of hippocampal dendritic spine density [77]. In aged rats, EE improves recovery of cognitive function following focal cerebral ischemia [79].…”

Section: Therapeutic Interventions Across the Lifespanmentioning

confidence: 99%

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

et al. 2016

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Improved stroke care has resulted in greater survival, but >50 % of patients have chronic disabilities and 33 % are institutionalized. While stroke rehabilitation is helpful, recovery is limited and the most significant gains occur in the first 2-3 months. Stroke triggers an early wave of gene and protein changes, many of which are potentially beneficial for recovery. It is likely that these molecular changes are what subserve spontaneous recovery. Two interventions, aerobic exercise and environmental enrichment, have pleiotropic actions that influence many of the same molecular changes associated with stroke injury and subsequent spontaneous recovery. Enrichment paradigms have been used for decades in adult and neonatal animal models of brain injury and are now being adapted for use in the clinic. Aerobic exercise enhances motor recovery and helps reduce depression after stroke. While exercise attenuates many of the signs associated with normal aging (e.g., hippocampal atrophy), its ability to reverse cognitive impairments subsequent to stroke is less evident. It may be that stroke, like other diseases such as cancer, needs to use multimodal treatments that augment complimentary neurorestorative processes.

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“…30 This non-invasive adjuvant treatment was effective in inducing recovery from impaired declarative memory for object recognition and in preserving hippocampal dendritic spine density in neonatal rats following hypoxia-ischemia. 17 EE has been shown to confer longterm cognitive benefits after traumatic brain injury in rats, including increasing the expression of genes important for signal transduction, calcium signaling pathways, membrane homeostasis, and metabolism in particular. 31,32 EE attenuated the production of cytokines and chemokines in response to lipopolysaccharides within the hippocampus and decreased hippocampal neuroinflammation during influenza infection in adult rodents.…”

Section: Discussionmentioning

confidence: 99%

“…16,21 EE consisted of a large cage (40 6 60 6 90 cm) with three floors, ramps, running wheels, and several objects of different shapes and textures ( Figure 1). Small changes were made once a week by adding new objects and withdrawing others.…”

Section: Environmental Enrichmentmentioning

confidence: 99%

“…15 The stimulation provided by EE fosters recovery from spatial memory deficits, 16 improves memory impairment on object recognition tests, and preserves hippocampal dendritic spine density following neonatal hypoxia-ischemia injury in rats. 17 EE has also been shown to attenuate the motor and cognitive deficits that result from traumatic brain injury. 18 We hypothesize that cognitive impairment in adult Wistar rats subjected to experimental pneumococcal meningitis during childhood will be reversed or mitigated by EE exposure.…”

Section: Introductionmentioning

confidence: 99%

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Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

Barichello

Fagundes

Generoso

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. Methods: On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 6 10 6 CFU/mL and remained with their mothers until age 21 days. Animals were divided into the following groups: control, control + EE, meningitis, and meningitis + EE. EE began at 21 days and continued until 60 days of age (adulthood). EE consisted of a large cage with three floors, ramps, running wheels, and objects of different shapes and textures. At 60 days, animals were randomized and subjected to habituation to the open-field task and the step-down inhibitory avoidance task. After the tasks, the hippocampus and CSF were isolated for analysis. Results: The meningitis group showed no difference in performance between training and test sessions of the open-field task, suggesting habituation memory impairment; in the meningitis + EE group, performance was significantly different, showing preservation of habituation memory. In the step-down inhibitory avoidance task, there were no differences in behavior between training and test sessions in the meningitis group, showing aversive memory impairment; conversely, differences were observed in the meningitis + EE group, demonstrating aversive memory preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were increased in the hippocampus, and BDNF levels in the CSF. Conclusions: The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis.

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Effects of daily environmental enrichment on behavior and dendritic spine density in hippocampus following neonatal hypoxia–ischemia in the rat

Cited by 105 publications

References 91 publications

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

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