Effects of Danshen tablets on pharmacokinetics of amlodipine in rats

Abstract

Context: Danshen tablets (DST), an effective traditional Chinese multi-herbal formula, are often combined with amlodipine (ALDP) for treating coronary heart disease. Objective: This study investigated the effects of DST on the pharmacokinetics of ALDP and the potential mechanism. Materials and methods: The pharmacokinetics of ALDP (1 mg/kg) in male Sprague–Dawley rats ( n = 6), with or without pretreatment of DST (100 mg/kg for 7 d), were investigated using LC-MS/MS. The effects of DST on the metabolic stability of ALDP were also investigated using rat liver microsomes (RLM). Results: The results indicated that C max (16.25 ± 2.65 vs. 22.79 ± 2.35 ng/ml), AUC (0– t ) (222.87 ± 59.95 vs. 468.32 ± 69.87 n gh/ml), and t 1/2 (10.60 ± 1.05 vs. 14.15 ± 1.59 h) decreased significantly when DST and ALDP were co-administered, which suggested that DST might influence the pharmacokinetic behaviour of ALDP when they are co-administered. The metabolic stability of ALDP was also decreased (23.6 ± 4.7 vs. 38.9 ± 5.2) with the pretreatment of DST. Discussion and conclusions: This study indicated that DST could accelerate the metabolism of ALDP in RLM and change the pharmacokinetic behaviours of ALDP. Accordingly, these results showed that the herb–drug interaction between DST and ALDP might occur when they were co-administered. Therefore, the clinical dose of ALDP should be increased when DST and ALDP are co-administered.

Analysis of Pharmaceutical Processes in Chinese Medicine Based on Quantity and Measure Value Transfer: A Case of Salvia miltiorrhiza Purified Extract Preparation

“…It has the effects of activating blood circulation, dispelling blood stasis, clearing and activating the channels and collaterals, clearing the heart and removing irritation, cooling the blood, relieving pain, etc. It is commonly used in clinical practice to treat coronary heart disease [8][9][10], angina pectoris [11][12][13], and ischemic stroke [14][15][16]. The phenolic components in Salvia miltiorrhiza, including salvianolic acid B, danshensu, protocatechuic aldehyde, and rosmarinic acid, are considered the main active ingredients, which are generally extracted by water decoction.…”

Pharmacokinetics of gallic acid and protocatechuic acid in humans after dosing with Relinqing (RLQ) and the potential for RLQ-perpetrated drug–drug interactions on organic anion transporter (OAT) 1/3

“…The combination of RLQ and conventional therapies has created a need to understand better the risks and benefits, especially the interaction of herbs and drugs (Ren et al 2019;Zhang et al 2019;Yang et al 2020). Evidence-based herbal drug interaction research is expected to become a necessary evaluation for the rational use of RLQ with other drugs prescribed for the same indications (Lu et al 2016).…”