Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes

Pereira, Maria J.; Carvalho, Eugénia; Eriksson, Jan W.; Crans, Debbie C.; Aureliano, Manuel

doi:10.1016/j.jinorgbio.2009.09.015

Cited by 90 publications

(47 citation statements)

References 43 publications

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“…[4][5][6][7][8][9][10][11] Furthermore, the antidiabetic, anti-virus, anti-bacterial and anti-tumor activities of V 10 and vanadate compounds are attracting increasing interest. [12][13][14][15][16][17][18] Decavanadate also exhibits insulin-mimetic behavior, and it was shown that, upon incubation with decavanadate, rat adipocytes accumulate much more glucose than with well-established mimetic agents such as BMOV. 18 Decavanadate is in many cases likely a pro-drug, inducing anti-diabetic activity through peroxovanadate production.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14][15][16][17][18] Decavanadate also exhibits insulin-mimetic behavior, and it was shown that, upon incubation with decavanadate, rat adipocytes accumulate much more glucose than with well-established mimetic agents such as BMOV. 18 Decavanadate is in many cases likely a pro-drug, inducing anti-diabetic activity through peroxovanadate production. 17 On the other hand, in vivo exposure to decavanadate, in comparison with vanadate, affects differently subcellular metal distribution, antioxidant enzyme activities, lipid peroxidation and tissue damage in several organs.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of decavanadate and decaniobate solutions by Raman spectroscopy

et al. 2016

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The decaniobate ion, (Nb 10 = [Nb 10 O 28 ] 6− ) being isoelectronic and isostructural with the decavanadate ion (V 10 = [V 10 O 28 ] 6− ), but chemically and electrochemically more inert, has been useful in advancing the understanding of V 10 toxicology and pharmacological activities. In the present study, the solution chemistry of Nb 10 and V 10 between pH 4 and 12 is studied by Raman spectroscopy. The Raman spectra of V 10show that this vanadate species dominates up to pH 6.45 whereas it remains detectable until pH 8.59, which is an important range for biochemistry. Similarly, Nb 10 is present between pH 5.49 and 9.90 and this species remains detectable in solution up to pH 10.80. V 10 dissociates at most pH values into smaller tetrahedral vanadate oligomers such as V 1 and V 2 , whereas Nb 10 dissociates into Nb 6 under mildly (10 > pH > 7.6) or highly alkaline conditions. Solutions of V 10 and Nb 10 are both kinetically stable under basic pH conditions for at least two weeks and at moderate temperature. The Raman method provides a means of establishing speciation in the difficult niobate system and these findings have important consequences for toxicology activities and pharmacological applications of vanadate and niobate polyoxometalates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of decavanadate and decaniobate solutions by Raman spectroscopy

et al. 2016

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“…Thapsigargin is one of the most potent inhibitors of the Ca 2+ -ATPases, and of all the E1-E2 ion pump inhibitors discussed in the present Perspective, with an IC 50 in the nM range of concentration. While vanadium and tungsten monoand polyoxometalates have IC 50 values which are three orders of magnitude (IC 50 = 2-15 μM) higher than TG, they still have activities comparable with other relevant ion pump inhibitors.…”

Section: Discussionmentioning

confidence: 87%

“…While vanadium and tungsten monoand polyoxometalates have IC 50 values which are three orders of magnitude (IC 50 = 2-15 μM) higher than TG, they still have activities comparable with other relevant ion pump inhibitors.…”

Section: Discussionmentioning

confidence: 93%

Ion pumps as biological targets for decavanadate

2013

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The putative applications of poly-, oligo-and mono-oxometalates in biochemistry, biology, pharmacology and medicine are rapidly attracting interest. In particular, these compounds may act as potent ion pump inhibitors and have the potential to play a role in the treatment of e.g. ulcers, cancer and ischemic heart disease. However, the mechanism of action is not completely understood in most cases, and even remains largely unknown in other cases. In the present review we discuss the most recent insights into the interaction between mono-and polyoxometalate ions with ion pumps, with particular focus on the interaction of decavanadate with Ca 2+ -ATPase. We also compare the proposed mode of action with those of established ion pump inhibitors which are currently in therapeutic use. Of the 18 classes of compounds which are known to act as ion pump inhibitors, the complete mechanism of inhibition is only known for a handful. It has, however, been established that most ion pump inhibitors bind mainly to the E2 ion pump conformation within the membrane domain from the extracellular side and block the cation release. Polyoxometalates such as decavanadate, in contrast, interact with Ca 2+ -ATPase near the nucleotide binding site domain or at a pocket involving several cytoplasmic domains, and therefore need to cross through the membrane bilayer.In contrast to monomeric vanadate, which only binds to the E2 conformation, decavanadate binds to all protein conformations, i.e. E1, E1P, E2 and E2P. Moreover, the specific interaction of decavanadate with sarcoplasmic reticulum Ca 2+ -ATPase has been shown to be non-competitive with respect to ATP and induces protein cysteine oxidation with concomitant vanadium reduction which might explain the high inhibitory capacity of V 10 (IC 50 = 15 μM) which is quite similar to the majority of the established therapeutic drugs.

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“…[1][2][3][4] In the past few decades, the vanadium complexes have been found to have interesting biological activities such as normalizing the high blood glucose levels and acting as models of haloperoxidases. [5][6][7][8][9][10][11] It has been known that there exists trigonal bipyramidal vanadium within the phosphatemetabolizing enzyme. 12, 13 Mokry and co-workers reported that the steric bulk of the substituent of the benzene ring can be used to modify the coordination geometry and/or number of vanadium atoms by preventing dimerization pathways.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Bond Induced Assembly and Crystal Structures of Dioxovanadium(v) Complexes With Schiff Bases

Liu

Zhang

2011

J. Chil. Chem. Soc.

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Two new dioxovanadium(V) complexes, [VO 2 L 1 ] (1) and [VO 2 L 2 ] 2 (2), where L 1 and L 2 are the deprotonated forms of 4-chloro-2-[(2-piperidin-1-ylethylimino) methyl]phenol and 2-ethoxy-6-[(2-ethylaminoethylimino)methyl]phenol, respectively, have been synthesized and characterized by i.r. spectra and single crystal X-ray diffraction. Complex (1) is a mononuclear dioxovanadium complex, with the V atom five-coordinate in a distorted square pyramidal geometry. Complex (2) is a dinuclear dioxovanadium complex, with the V atom six-coordinate in an octahedral geometry. The V•••V distance is 3.096(2) Å. The hydrogen bonds among the Schiff base ligands can influence the structures of the vanadium complexes.

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Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes

Cited by 90 publications

References 43 publications

Characterization of decavanadate and decaniobate solutions by Raman spectroscopy

Characterization of decavanadate and decaniobate solutions by Raman spectroscopy

Ion pumps as biological targets for decavanadate

Hydrogen Bond Induced Assembly and Crystal Structures of Dioxovanadium(v) Complexes With Schiff Bases

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