Effects of Desalted Deep Sea water on Hematologic and Blood Chemical Values in Mice

Tsuchiya, Yasuo; Watanabe, Atsuo; Fujisawa, Naoki; Kaneko, Takushi; Ishizu, Teiji; Fujimoto, Tsukasa; Nakamura, Kazutoshi; Yamamoto, Masahiro

doi:10.1620/tjem.203.175

Cited by 19 publications

(21 citation statements)

References 20 publications

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“…DSW has received increasing attention for various beneficial characteristics, such as low temperature, nutrition, sterility, stability and safety (8)(9)(10). It is known that high atmospheric pressure contributes to small and stable water molecules, ionization state and easy absorption of DSW.…”

Section: Introductionmentioning

confidence: 99%

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Fan¹,

Tan²,

Yue³

et al. 2016

Biomedical Reports

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Abstract. Physical fatigue is extremely common and occurs daily, and is considered to be associated with oxidative stress. The diverse functions of deep sea water (DSW) have recently gained increasing attention. Previous studies have emphasized the anti-fatigue effect of DSW, but the intrinsic mechanism behind the effect remains to be elucidated. In the imprinting control region (ICR) mice model, DSW delayed the exhaustive swimming time. In addition, DSW decreased the area under the blood lactate (BLA) curve, which was associated with the area under the BLA curve of pre-swimming, post-swimming and post-rest. Furthermore, DSW reduced the basal levels of malondialdehyde and the post-swimming concentration of blood urea nitrogen, lactate dehydrogenase and creatine kinase after swimming, along with an increase in the normal level of antioxidant enzyme activity such as superoxide dismutase and glutathione peroxidase. However, no significant effect on body weight, hepatic glycogen and muscle glycogen was observed between any group. In conclusion, DSW can improve the athletic ability and alleviate physical fatigue of ICR mice. This effect is achieved by enhancing the antioxidant capacity.

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Section: Introductionmentioning

confidence: 99%

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Fan¹,

Tan²,

Yue³

et al. 2016

Biomedical Reports

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“…They reported that there was no significant improvement by treated deep sea water on water intake. However, water intake of mice, received desalted deep sea water diluted to purified water with 20% were significantly (p<0.01) lower than mean water intake of natural DSW (Tsuchiya et al, 2004). Mirsalimi and Julian (1993) demonstrated that broilers become more enduring after three weeks of age to saline water containing 0.20% sodium.…”

Section: Amount Of Water Consumptionmentioning

confidence: 97%

“…The result of this study is in agreement with Kimura et al (2004) who reported non-significant effect on the mortality of the rats by treated deep sea water drinking. Moreover, Tsuchiya et al (2004) also reported no difference in mortality of mice received desalted deep sea water compared to mice received purified water. No differences in mortality in the present study indicated that the RO-DSW can be successfully used as drinking water for broiler.…”

Section: Growth Performancementioning

confidence: 99%

“…The development of the thymus and bursa of Fabricius as the part of lymphoid tissue has been described (Payne, 1971;Rose, 1979). Tsuchiya et al (2004) has compared desalted DSW with desalted surface sea water and purified water by measuring hematological values in mice. They found no significant differences in those values between the desalted DSW and purified water groups.…”

Section: The Relative Weight Of the Lymphoid Organs And Serum Immunogmentioning

confidence: 99%

“…Kimata et al (2002) reported that drinking of treated deep sea water was effective to reduce skin allergy. But it is also reported that the desalted DSW can be evaluated just safe as the ordinary purified water for drinking (Tsuchiya et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Drinking Reverse-osmosis Treated Deep Sea Water on Growth Performance and Immune Response in Broiler Chickens

Keohavong¹,

Lee²,

Lee³

et al. 2010

Journal of Animal Science and Technology

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This study was executed to investigate the effects of drinking deep sea water treated by reverse osmosis process (RO-DSW) on growth performance, nutrient utilizability, relative weight of lymphoid organs and the concentration of serum immunoglobulin G (IgG) in broiler chickens. A total of 200 one day old broiler chickens (Ross 308) were equally and randomly distributed into 10 ground floor pens (20 chicks per pen, 5 pens per treatment) bedded with rice-husks. The broilers were offered either fresh tap water (Control) or RO-DSW for 28 days (from d 6 to d 33) as the drinking water. The same basal phase 1 diet for first 2 weeks and phase 2 diet for last 2 weeks were offered ad libitum to the birds. The RO-DSW was prepared by diluting 1:20 ratio with deionized water before offering to chickens. The diet for control birds was supplemented with 0.21 % of food-grade salt to satisfy salt need of the birds. Broiler feeding study resulted that there were no differences in amount of water consumption, mortality and FCR between RO-DSW and control chickens. However, feed intake and body weight gain were increased (p<0.05) by RO-DSW drinking. There was no (p>0.05) difference in nutrients utilizability between RO-DSW and fresh water drinking. There were no (p>0.05) differences in the immune response between the control and treatment group. The serum IgG levels were 3.01 vs 2.87 mg/ml and the relative weights of spleen, thymus and bursa of Fabricius were 0.23, 0.18 and 0.20 vs. 0.20, 0.17 and 0.14 for RO-DSW vs. control birds, respectively. The immune responses were tended to be improved by RO-DSW drinking. This study showed an improvement in weight gain and feed intake that could be induced by RO-DSW drinking, although it is difficult to explain the reasons of the improvement at this moment. This study implied that RO-DSW could be successfully used as drinking water to broiler chickens.

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Blood Collection from Mice and Hematological Analyses on Mouse Blood

et al. 2013

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Basic phenotyping of inbred mouse strains and genetically modified mouse models usually includes the determination of blood-based parameters as a diagnostic screen for genotype effects on metabolism and organ function. A broad range of analytes, including hematological parameters, can be reliably determined in mouse blood, if appropriate samples are available. Here we describe recommended techniques for blood collection from mice and the considerations that have to be taken into account to get adequate samples for hematological investigations. Furthermore, we describe established methods used in the German Mouse Clinic (GMC) to determine hematological parameters in the mouse. Curr. Protoc. Mouse Biol. 3:101-119 © 2013 by John Wiley & Sons, Inc.

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Effects of Desalted Deep Sea water on Hematologic and Blood Chemical Values in Mice

Cited by 19 publications

References 20 publications

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model

Effects of Drinking Reverse-osmosis Treated Deep Sea Water on Growth Performance and Immune Response in Broiler Chickens

Blood Collection from Mice and Hematological Analyses on Mouse Blood

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