This chapter analyses the influence of bibliotherapy on the perceptions of readers (children, young people, and [older] adults) with special needs on their form of social interaction. By reading and writing, and by explaining to others what they read and write, by talking about plots, by expressing opinions and emotions, feelings and thoughts are articulated, and expressive (linguistic), relational, cognitive, and neurological abilities are improved. From linguistics (theoretical, applied, and cognitive), literary studies, translation/multilingual environments, and pedagogy (literacy, didactics of language, and literature), methodological approaches and interventions that can be useful and effective in bibliotherapy to activate neurocognitive abilities are provided. Furthermore, bibliotherapy is presented as a coherent option for improving the management of situations of confinement, physical, real, voluntary, imposed, or perceived loneliness.