Effects of diabetes on the vascular response to nitric oxide and constrictor prostanoids: gender and regional differences

Sanz, Elena; Fernández, Núria; Monge, Luis; Martínez, María Ángeles; Climent, Belén; Diéguez, Godofredo; Garcı́a-Villalón, Ángel Luis

doi:10.1016/s0024-3205(02)02444-x

Cited by 18 publications

(18 citation statements)

References 34 publications

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“…Similar results were reported in basilar, renal and tail arteries of rats for vasopressin and the thromboxane analog U46619 (García-Villaló n et al 2003;Sanz et al 2003). However, Calderone et al (2002) reported an increase in the noradrenaline sensitivity in aortas from male compared to female rats.…”

Section: Discussionsupporting

confidence: 76%

Differential vascular adaptive response to stress exposure in male and female rats: Role of gonadal hormones and endothelial cells

Júnior

Cordellini

2007

Stress

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Section: Discussionsupporting

confidence: 76%

Differential vascular adaptive response to stress exposure in male and female rats: Role of gonadal hormones and endothelial cells

Júnior

Cordellini

2007

Stress

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“…As a result, the negative association between CAS and hypertension indicates that two different vascular pathologies exist in CAS and hypertension, especially in women. Although diabetes mellitus has impaired vasoconstriction in response to different vasoconstrictors [30], [31], data on the effects of diabetes mellitus on the vascular response to acetylcholine, an inducer of CAS, however, are discrepant, which may be due to the differential effects of diabetes mellitus on the vascular bed studied [32].…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein for Predicting Prognosis and Its Gender-Specific Associations with Diabetes Mellitus and Hypertension in the Development of Coronary Artery Spasm

Hung

Hsu

et al. 2013

PLoS ONE

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BackgroundWhile hypertension is negatively associated with coronary artery spasm (CAS), scarce data are available on diabetes mellitus in relation to CAS. In addition, outcome prediction in patients with CAS is challenging due to the lack of appropriate biomarkers. Therefore, we sought to identify the roles that gender, high-sensitivity C-reactive protein (hs-CRP), diabetes mellitus and hypertension play in CAS development and prognosis.Methodology/Prinicpal FindingsPatients (350 women and 547 men) undergoing diagnostic coronary angiography with or without proven CAS but without obstructive stenosis were evaluated at long-term follow-up (median 102 months). Diabetic women and diabetic men with low hs-CRP levels had a low and high risk of CAS (odds ratio [OR]: 0.16, 95% confidence interval [CI]: 0.01–1.88 and OR: 5.02, 95% CI: 1.03–24.54, respectively). The ORs of CAS in both women and men with the highest hs-CRP tertile (>3 mg/L) reduced from 4.41 to 1.45 and 2.98 to 1.52, respectively, if they had diabetes mellitus, and from 9.68 to 2.43 and 2.60 to 1.75, respectively, if they had hypertension. Hypertension had a more negative effect on CAS development in diabetic than non-diabetic women, which was not observed in men. The highest hs-CRP tertile was an independent predictor of adverse outcomes. Patients with the highest hs-CRP tertile had more coronary events than patients with the lowest hs-CRP tertitle (p = 0.021, log-rank test).ConclusionsDiabetes mellitus contributes to CAS development in men with low hs-CRP levels, but not in women. There are negative effects of diabetes mellitus and hypertension on CAS development in patients with high hs-CRP levels and especially in women. Elevated hs-CRP level independently predicts adverse outcomes.

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“…These data support the specificity of the changes in modulatory mechanisms of the arterial response to endothelin-1 mentioned above, and show that changes in vascular reactivity induced by diabetes may vary depending on the species, vascular bed, and stimuli studied. A recent study reports the existence of sex and regional differences in the alterations induced by diabetes on the reactivity of vascular smooth muscles (Sanz et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1

Lloréns

Miranda

Alabadí

et al. 2004

European Journal of Pharmacology

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The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal or N G -nitro-L-arginine enhanced contractions in response to endothelin-1 only in control arteries, without modifying the endothelin-1 response in diabetic arteries. Indomethacin, furegrelate (thromboxane A 2 inhibitor), or cyclo-(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123; endothelin ET A receptor antagonist) inhibited the contractions in response to endothelin-1, the inhibition being greater in diabetic arteries than in control arteries. 2,6-Dimethylpiperidinecarbonyl-g-methyl-Leu-N in -(methoxycarbonyl)-D-Trp-D-Nle (BQ-788; endothelin ET B receptor antagonist) enhanced the contraction elicited by endothelin-1 in control arteries and displaced to the right the contractile curve for endothelin-1 in diabetic arteries. In summary, diabetes induces hyperreactivity of the rabbit carotid artery to endothelin-1 by a mechanism that at least includes: (1) enhanced activity of muscular endothelin ET A receptors; (2) impairment of endothelin ET B receptor-mediated nitric oxide (NO) release; and (3) enhancement of the production of thromboxane A 2 .

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Effects of diabetes on the vascular response to nitric oxide and constrictor prostanoids: gender and regional differences

Cited by 18 publications

References 34 publications

Differential vascular adaptive response to stress exposure in male and female rats: Role of gonadal hormones and endothelial cells

Differential vascular adaptive response to stress exposure in male and female rats: Role of gonadal hormones and endothelial cells

C-Reactive Protein for Predicting Prognosis and Its Gender-Specific Associations with Diabetes Mellitus and Hypertension in the Development of Coronary Artery Spasm

Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1

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