Effects of diazinon and diazoxon on the lymphoproliferation rate of splenocytes from Nile tilapia (Oreochromis niloticus): The immunosuppresive effect could involve an increase in acetylcholine levels

Girón-Pérez, Manuel Iván; Zaitseva, Galina; Casas‐Solís, Josefina; Santerre, Anne

doi:10.1016/j.fsi.2008.07.002

Cited by 32 publications

(15 citation statements)

References 32 publications

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“…In contrast, the disruption of the neuroimmune communication, particularly the cholinergic system, is another possible mechanism for the immunotoxicity of OPs (Girón-Pérez et al, 2008). In addition, extra-neuronal cholinergic activity has been reported in mammalian lymphocytes (Kawashima and Fujii, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the lymphocytic cholinergic system could be the target for OPs in the immunotoxicity phenomenon (Charoenying et al, 2011). Data from our research group have shown that in vitro exposure to diazinon and diazoxon did not alter the proliferative capacity of tilapia lymphocytes, even though these substances induced an increase in the concentration of ACh, molecule that caused a significant diminishment in lymphoproliferation (Girón-Pérez et al, 2008).…”

Section: Introductionmentioning

confidence: 92%

“…Apart from the possible direct immunotoxic mechanisms, it has also been suggested that an indirect mechanism can be related with the interruption of neuroimmune communication, altering particularly the cholinergic neuronal system and its influence on the immune response (Galloway and Handy, 2003;Girón-Pérez et al, 2008). However, it has been recently proven that, in mammalian models, neurons are not the only cells that express ACh.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Toledo-Ibarra

Díaz-Reséndiz

Pavón

et al. 2016

Veterinary Immunology and Immunopathology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Toledo-Ibarra

Díaz-Reséndiz

Pavón

et al. 2016

Veterinary Immunology and Immunopathology

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“…19 Blood IgA, IgM and IgG levels were measured with a commercially available ELISA kit. Natural killer (NK) cells activity was measured according to the method of Li.…”

Section: Biochemical Analysismentioning

confidence: 99%

Evaluation of Chemoprotective Effect of Quercetin from Argyreia speciosa against N-methyl-N-Nitro-N-Nitrosoguanidine and NaCl-Induced Gastric Carcinomas in Wistar Rats

Azmi¹,

Shukla²,

Gupta³

et al. 2018

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Objectives: This study was carried out to investigate the chemo protective potential of Quercetin, an isolated compound from Argyreia speciosa, on N-methyl-N-nitro-N-nitrosoguanidine and NaCl-induced gastric carcinomas in Wistar rats. Methods: The rats were fed with a diet supplemented with 8% NaCl and simultaneously given N-methyl-N-nitro-N-nitrosoguanidine. After administration of the carcinogen, quercetin was administered. The whole stomach and a part of duodenum were sampled, cut open and tumors were recorded. The specimens were histopathologically investigated and the expression of surviving was examined with immunohistochemical analysis. Results and Conclusion: The treatment with quercetin significantly increases body weight in the rats after N-methyl-N-nitro-N-nitrosoguanidine administration. Survivin expression in glandular stomachs of normal rats, of rats in adenocarcinomas and quercetin at dose dependent manner treated rats were 0%, 90%, 75%, 33.3-25%, respectively. Compared with the survivin expression in negative rats, the differences were significant. Compared with the survivin expression in normal rats, the differences were significant. Histological observations of stomach tissues too correlated with the biochemical observations. These findings indicated that the Quercetin treatment could stimulate immunity activity in rats with N-methyl-N-nitro-N-nitrosoguanidine induced gastric carcinoma and have pronounced effect on survivin which is an attractive target for gastric cancer therapy.

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“…Furthermore, diazinon has also been implicated in immunosuppression in fish and animal models e.g., laboratory rodents (Galloway & Handy, 2003;Girón-Pérez et al, 2006;2008;Alhammaly, 2013;Díaz-Resendiz et al, 2015). However, no data were found in literature regarding immunotoxic effects of DZN in turtle species.…”

Section: Introductionmentioning

confidence: 99%

Effects of diazinon on some innate resistance parameters in the Caspian pond turtle (Mauremys caspica caspica)

Soltanian¹,

Fallahi²,

Fereidouni³

2018

BJVM

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Effects of diazinon and diazoxon on the lymphoproliferation rate of splenocytes from Nile tilapia (Oreochromis niloticus): The immunosuppresive effect could involve an increase in acetylcholine levels

Cited by 32 publications

References 32 publications

Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish (Oreochromis niloticus)

Evaluation of Chemoprotective Effect of Quercetin from Argyreia speciosa against N-methyl-N-Nitro-N-Nitrosoguanidine and NaCl-Induced Gastric Carcinomas in Wistar Rats

Effects of diazinon on some innate resistance parameters in the Caspian pond turtle (Mauremys caspica caspica)

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