Effects of diet composition on liver antioxidant defense and detoxification enzymes in mice with murine AIDS

Huang, Chien‐Ning; Chen, L.H.; Osio, Y.; Cohen, Donald A.

doi:10.1016/s0271-5317(05)80720-1

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…The composition of diet administered to rats could affect the activity of antioxidative enzymes (SOD and GPx) responsible for the functions of the system, which protects the organism against effects of reactive oxygen species (ROS) and oxidative degradation of cells [ 48 ]. It has been proven experimentally that the activity of these markers may be modulated by ingestion of flaxseed-containing diet [ 49 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of Dose and Administration Period of Seed Cake of Genetically Modified and Non-Modified Flax on Selected Antioxidative Activities in Rats

Matusiewicz

Kosieradzka

Żuk

et al. 2015

IJMS

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Flaxseed cake containing antioxidants is a valuable dietary component. Its nutritional effect may be diminished by the presence of anti-nutrients. The work was aimed at determining the effect of different contents of flaxseed cake in diets and their administration period on the development of rats and selected parameters of their health status. Diets with 15% and 30% addition of genetically modified (GM) flax seed cake with enhanced synthesis of polyphenols, as well as Linola non-GM flax were administered in short-term (33 days) and long-term (90 days) experiments. The 30% addition of flaxseed cake reduced digestibility of dietary nutrients, GM flaxseed cake lowered body weight gains. The relative weight of selected organs, hematological blood markers and serum activities of aspartate and alanine aminotransferases (AST, ALT) were not affected. Flaxseed cake consumption reduced serum concentration of albumins and increased globulins. Administration of 30% flaxseed cake improved plasma total antioxidant status and 30% GM flaxseed cake lowered liver thiobarbituric acid reactive substances. The activities of superoxide dismutase in erythrocytes, glutathione peroxidase in plasma and the liver concentration of 8-oxo-2′-deoxyguanosine were not changed. Most morphometric parameters of the small intestine did not differ between feeding groups. The administration of diets with 30% addition of flaxseed cake for 90 days improved the antioxidant status in rats.

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Section: Resultsmentioning

confidence: 99%

Effect of Dose and Administration Period of Seed Cake of Genetically Modified and Non-Modified Flax on Selected Antioxidative Activities in Rats

Matusiewicz

Kosieradzka

Żuk

et al. 2015

IJMS

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“…The role of the antioxidant defence system, which includes Cu/Zn superoxide dismutase (EC 1.15.1.1; Cu/ Zn SOD), catalase (EC 1.11.1.6; CAT), and glutathione peroxidase (EC 1.11.1.9; GSH-Px), in protection against oxidative insults is well characterized in the liver, and it has been suggested that this antioxidant defence system may be influenced by nutrition (Huang et al 1994).…”

mentioning

confidence: 99%

Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver

et al. 1999

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The effects of two oleic-acid-rich diets (containing olive oil, OO, and high-oleic-acid sunflower oil, HOSO) on plasma and liver lipid composition detoxification enzyme activities, were compared with those of a fish-oil (FO) diet and a control diet. Compared with the control diet, plasma and hepatic total triacylglycerol concentrations were increased in the animals fed on the HOSO and OO diets and decreased in those fed on the FO diet. The animals fed on FO showed the highest level of cholesterol in the liver and had lower plasma cholesterol concentrations when compared with those fed on the two oleic-acid-rich diets. In comparison with the animals fed on the diets enriched in oleic acid, the FO group showed higher hepatic levels of polyunsaturated fatty acids of the n-3 series and lower levels of fatty acids of the n-6 series. Livers of FO-fed rats, compared with those of OO-and HOSO-fed rats showed: (1) significantly higher activities of catalase (EC 1.11.

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“…Increasing evidence suggests that essential hypertension is associated with elevated oxygen free radical production and decreased antioxidant capacity [1][2][3]. As diet can affect the endogenous free radical production and modulates the antioxidant status [11,12], the present study was designed to compare the effect of different dietary fats on liver antioxidant activities in spontaneously hypertensive rats (SHR). The plasma and liver lipid composition was also studied.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we have described that liver antioxidant enzyme activities may be modulated by consumption of different oils (OO, HOSO, and FO) in normotensive rats [11]. The antioxidant defence system in liver includes Cu͞Zn superoxide dismutase (Cu͞Zn-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), enzymes that may be modulated by nutritional factors [12].…”

Section: Introductionmentioning

confidence: 99%

Liver Lipid Composition and Antioxidant Enzyme Activities of Spontaneously Hypertensive Rats After Ingestion of Dietary Fats (Fish, Olive and High-Oleic Sunflower Oils)

2001

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Hypertension is associated with greater than normal lipoperoxidation and an imbalance in antioxidant status, suggesting that oxidative stress is important in the pathogenesis of this disease. Although many studies have examined the effect of antioxidants in the diet on hypertensión and other disorders, less attention has been given to the evaluation of the role of specific dietary lipids in modulating endogenous antioxidant enzyme status. Previously, we have described that liver antioxidant enzyme activities may be modulated by consumption of different oils in normotensive rats. The purpose of the present study was to examine the effects of feeding different lipidic diets (olive oil, OO, high-oleic-acid sunflower oil, HOSO, and fish oil, FO) on liver antioxidant enzyme activities of spontaneously hypertensive rats (SHR). Plasma and liver lipid composition was also studied. Total triacylglycerol concentration increases in plasma and liver of animals fed on the HOSO and OO diets and decreases in those fed on the FO diet, relative to rats fed the control diet. The animals fed on the oil-enriched diet show similar hepatic cholesterol and phospholipid contents, which are higher than the control group. Consumption of the FO diet results in a decrease in the total cholesterol and phospholipid concentration in plasma, compared with the high-oleic-acid diets. In liver, the FO group show higher levels of polyunsaturated fatty acids (PUFA) of the (n - 3) series, in relation to the animals fed on the diets enriched in oleic acid. Livers of FO-fed rats, compared with those of OO- and HOSO-fed rats showed: (i) significantly higher activities of catalase, glutathione peroxidase and Cu/Zn superoxide dismutase; (ii) no differences in the NADPH-cytochrome c reductase activity. The HOSO diet had a similar effect on liver antioxidant enzyme activities as the OO diet. In conclusion, it appears that changes in the liver fatty acid composition due mainly to n - 3 lipids may enhance the efficiency of the antioxidant defence system and may yield a benefit in the hypertension status. The two monounsaturated fatty acids oils studied (OO and HOSO), with the same high content of oleic acid, but different content of natural antioxidants, had similar effects on the antioxidant enzyme activities studied.

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Effects of diet composition on liver antioxidant defense and detoxification enzymes in mice with murine AIDS

Cited by 11 publications

References 27 publications

Effect of Dose and Administration Period of Seed Cake of Genetically Modified and Non-Modified Flax on Selected Antioxidative Activities in Rats

Effect of Dose and Administration Period of Seed Cake of Genetically Modified and Non-Modified Flax on Selected Antioxidative Activities in Rats

Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver

Liver Lipid Composition and Antioxidant Enzyme Activities of Spontaneously Hypertensive Rats After Ingestion of Dietary Fats (Fish, Olive and High-Oleic Sunflower Oils)

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