Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program

Abstract

BackgroundThe purpose of this study was to determine whether sedentary obese women with knee OA initiating an exercise and weight loss program may experience more beneficial changes in body composition, functional capacity, and/or markers of health following a higher protein diet compared to a higher carbohydrate diet with or without GCM supplementation.MethodsThirty sedentary women (54 ± 9 yrs, 163 ± 6 cm, 88.6 ± 13 kg, 46.1 ± 3% fat, 33.3 ± 5 kg/m2) with clinically diagnosed knee OA participated in a 14-week exercise and weight loss program. Participants followed an isoenergenic low fat higher carbohydrate (HC) or higher protein (HP) diet while participating in a supervised 30-minute circuit resistance-training program three times per week for 14-weeks. In a randomized and double blind manner, participants ingested supplements containing 1,500 mg/d of glucosamine (as d-glucosamine HCL), 1,200 mg/d of chondroitin sulfate (from chondroitin sulfate sodium), and 900 mg/d of methylsulfonylmethane or a placebo. At 0, 10, and 14-weeks, participants completed a battery of assessments. Data were analyzed by MANOVA with repeated measures.ResultsParticipants in both groups experienced significant reductions in body mass (-2.4 ± 3%), fat mass (-6.0 ± 6%), and body fat (-3.5 ± 4%) with no significant changes in fat free mass or resting energy expenditure. Perception of knee pain (-49 ± 39%) and knee stiffness (-42 ± 37%) was decreased while maximal strength (12%), muscular endurance (20%), balance indices (7% to 20%), lipid levels (-8% to -12%), homeostasis model assessment for estimating insulin resistance (-17%), leptin (-30%), and measures of physical functioning (59%), vitality (120%), and social function (66%) were improved in both groups with no differences among groups. Functional aerobic capacity was increased to a greater degree for those in the HP and GCM groups while there were some trends suggesting that supplementation affected perceptions of knee pain (p < 0.08).ConclusionsCircuit style resistance-training and weight loss improved functional capacity in women with knee OA. The type of diet and dietary supplementation of GCM provided marginal additive benefits.Trial RegistrationClinicalTrials.gov: NCT01271218

Chondroitin for osteoarthritis

“…Data were usable from 30 studies in the meta-analysis. Examples of some studies with non-usable data were as follows: the treatment regimens were too different from the cohort of included studies (Alekseeva 2008; Cohen 2003; Magrans-Courtney 2011; Nguyen 2001), or they did not report clinical data (Rovetta 2002; Rovetta 2004). …”

“…Sample sizes ranged from ≤ 30 participants in a few trials (e.g., Magrans-Courtney 2011; Rovetta 2002) to 1,583 in the GAIT trial (Clegg 2006). Most studies had a sample size larger than 50 participants; in particular, several studies had sample sizes of 100 or more (Alekseeva 1999; Alekseeva 2005a; Alekseeva 2008; Clegg 2006; Gabay 2011; Kahan 2009; L’Hirondel 1992; Mazieres 2001; Michel 2005; Moller 2010; Morreale 1996; Nasonova 2001; Pavelka 1999; Pavelka 2010; Rai 2004; Sawitzke 2008; Sawitzke 2010; Uebelhart 2004; Fardellone 2013).…”

“…Many studies were single-center studies (e.g., Magrans-Courtney 2011; Nakasone 2011; Rovetta 2002; Uebelhart 2004). Other studies were multicenter studies (e.g., Clegg 2006; Uebelhart 2004; Wildi 2011).…”

Efecto de la administración subcrónica de glucosamina oral en la regulación del peso corporal, glucemia y dislipidemias provocada por una dieta hipercalórica en rata Wistar

“…Si bien se conoce que la osteoartritis o enfermedad articular degenerativa es uno de los padecimientos más importantes de este siglo, con un número cada vez mayor de de personas que la presenta ya que, debido al sobrepeso u obesidad, las personas aceleran el desgaste natural de la articulación, se pone en cuestión si la administración crónica de la glucosamina para el tratamiento de la osteoartritis resulta adyacente al tratamiento de la regulación del peso corporal y por ende de las dislipidemias, reportándose que propician beneficios limitados según el tipo de dieta involucrada con su administración y efecto en el sobrepeso 20,21 .…”

Cissus QuadrangularisReduces Joint Pain in Exercise-Trained Men: A Pilot Study

“…1,2 This is particularly true for individuals engaged in weight-bearing exercise, such as running, bodybuilding, and powerlifting, for which the volume and/or loading can be very high. 3,4 In an attempt to lessen joint pain associated with chronic physical activity, certain nutritional supplements 5 and isolated ingredients [6][7][8] have been used with some success. The two isolated ingredients that have received the most attention in recent years are glucosamine and methylsulfonylmethane (MSM).…”