Effects of Dietary and Lighting Conditions on Diurnal Locomotor Activity and Body Temperature in Microminipigs

doi:10.21873/invivo.11204

Cited by 3 publications

(2 citation statements)

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“…The utility of MMPigs as experimental animals has been demonstrated in life science research. Similarly, as other minipigs, the MMPig represents a potentially appropriate experimental model because its lipoprotein metabolism (19)(20)(21), anatomy, physiology, and feeding and sleep habits (22)(23)(24) are similar to those of humans.…”

Section: In Vivo Metabolism Of 15-anhydro-d-fructose To 15-anhydro-d-...mentioning

confidence: 99%

In VivoMetabolism of 1,5-Anhydro-d-fructose to 1,5-Anhydro-d-glucitol

Ijiri

Yoshinaga²,

Kawaguchi

et al. 2023

In Vivo

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Background/Aim: 1,5-Anhydro-D-fructose (1,5-AF, saccharide) and 1,5-anhydro-D-glucitol (1,5-AG) converted from 1,5-AF via the glycemic pathway have health benefits. However, this metabolism has not been sufficiently elucidated. To clarify the in vivo metabolism of 1,5-AF to 1,5-AG, porcine (blood kinetics) and human (urinary excretion) studies were conducted. Materials and Methods: Microminipigs were administrated 1,5-AF orally or intravenously. Blood samples were obtained to analyse the kinetics of 1,5-AF and 1,5-AG. Urine samples were collected from human subjects who had orally ingested 1,5-AF, and the amounts of 1,5-AF and 1,5-AG excreted in the urine were analysed. Results: In blood kinetics analysis, the time to the maximum concentration of 1,5-AF after intravenous administration was 0.5 h, whereas 1,5-AF was not observed after oral administration. The times to the maximum concentration of 1,5-AG after intravenous and oral administration were 1.5 h and 2 h, respectively. In urinary excretion, the concentration of 1,5-AG in urine rapidly increased after the administration of 1,5-AF, peaked at 2 h, whereas 1,5-AF was not detected. Conclusion: 1,5-AF was rapidly metabolized to 1.5-AG in vivo in swine and human.

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Section: In Vivo Metabolism Of 15-anhydro-d-fructose To 15-anhydro-d-...mentioning

confidence: 99%

In VivoMetabolism of 1,5-Anhydro-d-fructose to 1,5-Anhydro-d-glucitol

Ijiri

Yoshinaga²,

Kawaguchi

et al. 2023

In Vivo

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show abstract

“…Swine are considered to be increasingly attractive toxicological and pharmacological models because of their well-accepted physiological and anatomical similarities to humans (5)(6)(7)(8)(9)(10). Microminipigs (brand name; registered with the Japanese Ministry of Agriculture, Forestry and Fisheries as a novel variety of swine; Fuji Micra Inc., Shizuoka, Japan) have emerged as an experimental animal model of non-clinical pharmacological and toxicological research (11)(12)(13)(14).…”

mentioning

confidence: 99%