Effects of dietary and pharmacological manipulations on appetitive and consummatory aspects of feeding in non-human primates

Foltin, Richard W.

doi:10.1016/j.appet.2005.03.011

Cited by 15 publications

(9 citation statements)

References 48 publications

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“…The ethological descriptors “appetitive” and “consummatory” (Craig 1918) have been used to distinguish specific classes of behavior associated with biologically important acts such as eating (Foltin 2005) and mating (Balthazart et al 1998). The appetitive/consummator distinction has been helpful in characterizing the separate neural systems involved (Gan et al 2010; Nicola and Deadwyler 2000; Pettit and Justice 1989).…”

Section: Introductionmentioning

confidence: 99%

A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid

2010

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Rationale Behavior occurring during cocaine self-administration can be classified as either consummatory or appetitive. These two concepts are usually addressed independently using separate reinforcement schedules. For example, appetitive behavior can be assessed with a progressive ratio schedule, whereas consummatory behavior is typically measured using a fixed ratio schedule. Objectives Depending on the schedule used, it is often difficult to determine whether a particular drug pretreatment is affecting self-administration through an effect on appetitive responding, consummatory responding, or perhaps both. In the present study, we tested the effect of pretreating rats with four different drugs on appetitive and consummatory behaviors. Materials and methods We recently developed a technique that provides an independent assessment of both behavioral concepts within the same experimental session. In this threshold procedure, rats are offered a descending series of 11 unit doses (422–1.3 μg/injection) during consecutive timed intervals under a fixed-ratio schedule. Consummatory behavior can be analyzed by assessing intake at high unit doses; an estimate of appetitive responding can be determined from responding occurring at the threshold dose. Applying behavioral economics to these data provides dependent measures of consumption when minimally constrained by price and the maximal price paid (Pmax) for cocaine. Results Haloperidol increased cocaine consumption when minimally constrained by price but decreased Pmax. In contrast, d-amphetamine increased Pmax. Fluoxetine decreased Pmax and consumption when minimally constrained by price. Baclofen selectively decreased Pmax. Conclusions These data suggest that drug pretreatments can alter consummatory and appetitive behavior differently because each concept involves distinct neural mechanisms.

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Section: Introductionmentioning

confidence: 99%

A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid

2010

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“…Some studies have at looked at hourly intake during intervals of four to twelve hours (Blundell et al, 1976; Caul et al, 1988; Jones and Caul, 1989). When the effects of amphetamine across even longer intervals have been considered, investigators have tended to measure total intake at the end of a long interval such as 24 hours (Chen et al, 2001; Foltin, 2005). Few studies have periodically sampled food intake during the circadian interval following amphetamine administration.…”

Section: Introductionmentioning

confidence: 99%

The effects of dose and repeated administration on the longer-term hypophagia produced by amphetamine in rats

White

Hundley

White

2010

Pharmacology Biochemistry and Behavior

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Rats are hypophagic approximately 1 to 3 and 13-27 hours after receiving amphetamine (2.0 mg/kg). This study examined how these short- and longer-term phases of hypophagia were affected by repeated administration of different amphetamine doses. Throughout eight five-day tests, rats could lever press for food pellets for one-hour periods beginning every three hours. On test day 1, rats were treated with saline, and on test day 3, they were treated with a dose of amphetamine. Across tests, for one group treatment on day 3 alternated between 0.0 (saline) and 0.5 mg/kg amphetamine; for a second group treatment on day 3 alternated between 1.0 and 2.0 mg/kg amphetamine; and for a third group, treatment on day 3 was always 1.0 mg/kg amphetamine. Patterns of food intake following day 1 saline and day 3 treatment were compared. Short-term food intake was abolished by 0.5, 1.0, and 2.0 mg/kg amphetamine, and no tolerance was observed to this effect. Longer-term hypophagia was produced by 1.0 and 2.0 but not by 0.5 mg/kg. Tolerance to longer-term hypophagia was seen when 1.0 mg/kg alone was used as the day 3 treatment, but not when 1.0 and 2.0 mg/kg were alternated across tests as the day 3 treatment. Short- and longer-term hypophagia were dissociated by threshold doses for elicitation and by differential tolerance. Occasional receipt of a higher amphetamine dose may sometimes increase the longer-term hypophagia produced by a lower dose.

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“…For example, haloperidol has been shown to lower breakpoint values in rats responding under progressive-ratio schedules for sucrose reinforcers, which suggests that it can reduce the effectiveness of sucrose and other gustatory stimuli such as food as a reinforcer (Mobini, Chiang, Ho, Bradshaw, & Szabadi, 2000;Reilly, 1999). CNS stimulants can also decrease food intake in nonhuman primates (e.g., Foltin, 2005), which suggests the possibility that the combination of the two drugs might work additively to eliminate food-maintained responding in the acquisition and performance components entirely. Yet, haloperidol's effects on food-maintained responding were attenuated or antagonized in the acquisition and performance components, respectively, when intermediate infusion doses of cocaine were self-administered (e.g., see Figure 6).…”

Section: Discussionmentioning

confidence: 99%

Differential Antagonism of Cocaine Self—administration and Cocaine—induced Disruptions of Learning by Haloperidol in Rhesus Monkeys

Winsauer

Moerschbaecher

Roussell

2008

J Exper Analysis Behavior

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Six rhesus monkeys responding under a three-component multiple schedule were administered haloperidol to determine its effects on cocaine self-administration and on cocaine's disruptive effects on the repeated acquisition and performance of response chains. In the absence of haloperidol, 0.0032-0.032 mg/kg/infusion of cocaine increased response rate and the number of infusions in the selfadministration component when compared to saline administration, whereas 0.1-0.32 mg/kg/infusion decreased response rate and the number of infusions. When compared to saline administration, the two lowest infusion doses of cocaine had little or no effect on responding in the acquisition and performance components; however, higher infusion doses of cocaine dose-dependently decreased response rate in these components. In addition, the higher doses of cocaine also increased the percentage of errors in the acquisition and performance components. Pretreatment with haloperidol (0.0032 or 0.01 mg/kg, i.m.) antagonized the effects of low doses of cocaine on the number of infusions in the self-administration component, whereas only the 0.01-mg/kg dose antagonized the effects of high doses of cocaine on the number of infusions. Neither dose of haloperidol antagonized the ratedecreasing effects of cocaine on responding in the acquisition and performance components significantly; the highest dose of haloperidol alone decreased rates of responding in each component. Antagonism of cocaine's error-increasing effects by haloperidol was only evident at one dose of cocaine (0.032 mg/kg/infusion), and was more complete in the performance components than in the acquisition components. Together, these data show the limited suitability of haloperidol for selectively antagonizing cocaine self-administration in the context of a multiple schedule involving transition behavior, and show the lack of uniform antagonism across operant behaviors.

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Effects of dietary and pharmacological manipulations on appetitive and consummatory aspects of feeding in non-human primates

Cited by 15 publications

References 48 publications

A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid

A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid

The effects of dose and repeated administration on the longer-term hypophagia produced by amphetamine in rats

Differential Antagonism of Cocaine Self—administration and Cocaine—induced Disruptions of Learning by Haloperidol in Rhesus Monkeys

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