Effects of dietary anticarcinogens on rat gastrointestinal glutathione peroxidase activity.

Lieshout, Esther M.M. Van; Ekkel, M.P.C.; Bedaf, M.M.G.; Nijhoff, W.A.; Peters, Wilbert H.M.

doi:10.3892/or.5.4.959

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…Besides, limonene, a natural product constituting up to 95% of orange peel oil and some essential oils, was observed to increase glutathione S ‐transferase in the liver and colon of rats [27]. Moreover, it was shown that d ‐limonene induced all three types of glutathione peroxidase activities in the oesophagus; also d ‐limonene induced colonic t‐glutathione peroxidases and non‐selenium glutathione peroxidase activity [28]. The modulation effect exerted by limonene on the enzymes could explain the results obtained when the H 2 O 2 level was measured in presence of limonene.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H₂O₂ Modulation and Cell Proliferation

Davicino

Micucci

Turner

et al. 2009

Basic Clin Pharma Tox

176

100

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Limonene is a monoterpene present in citrus fruit and is used as flavouring agents of foods. It was shown that monoterpenes possess antioxidant activity. Previously, it was demonstrated that limonene exerts anti-proliferative action on a lymphoma cell line without modifying normal lymphocyte viability. H 2 O 2 has a modulator role in cell proliferation. In the present study, the effect of limonene on normal lymphocytes proliferation and its relation with H 2 O 2 level modulation was analysed, evaluating its effect on the activity of cell antioxidant enzymes, such as catalase, peroxidase and superoxide dismutase. Limonene exerted a biphasic effect on cell proliferation; the increase in cell proliferation was related to the decrease in H 2 O 2 level by the increase in catalase and peroxidase activities. Moreover, limonene protected the cells to the oxidative stress induced by exogenous addition of H 2 O 2 . In view of these results, it is possible that limonene could protect normal lymphocytes from diseases related to oxidative stress, including cancer, but further research is necessary to establish the role of limonene as a potential antioxidant that can effectively protect lymphocytes from oxidative stress and mitochondrial dysfunction.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H₂O₂ Modulation and Cell Proliferation

Davicino

Micucci

Turner

et al. 2009

Basic Clin Pharma Tox

176

100

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“…An abundance of data implicating a potential role of selenium as a chemopreventive agent in animal models Effects of selenium on mesothelioma cells and SEP15 status S Apostolou et al and humans (Hunter et al, 1990;El-Bayoumy, 1991;van den Brandt et al, 1993;Zhang et al, 1997;Ip, 1998;van Lieshout et al, 1998) (Jones and Baylin, 2002). Such epigenetic changes are common in cancer and are thought to affect multiple steps in tumor progression.…”

Section: Discussionmentioning

confidence: 99%

“…Selenium is an essential trace element in redox pathways and has been utilized as a chemopreventive agent (Zhang et al, 1997;Ip, 1998;van Lieshout et al, 1998). Chemoprevention studies in animal model systems have shown that selenium is protective against a variety of carcinogens (El-Bayoumy, 1991).…”

Section: Introductionmentioning

confidence: 99%

Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype

et al. 2004

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Malignant mesotheliomas (MMs) are aggressive tumors derived from mesothelial cells lining the lungs, pericardium and peritoneum, and are often associated with occupational asbestos exposure. Suppression subtractive hybridization was used to identify genes differentially expressed in MM cells compared to normal mesothelial cells. A gene, SEP15, encoding a 15-kDa seleniumcontaining protein was isolated using this approach and was subsequently shown to be downregulated in B60% of MM cell lines and tumor specimens. A SEP15 polymorphic variant, 1125A, resides in the SECIS recognition element in the 3 0 -UTR and may influence the efficiency of Sec incorporation into the protein during translation. Since previous studies have implicated a potential role of the trace element selenium as a chemopreventive agent in animal models and in several types of human cancer, we investigated the effect of selenium on MM cells and its dependence on SEP15 genotype. Selenium was shown to inhibit cell growth and induce apoptosis in a dosedependent manner in MM cells but had minimal effect on normal mesothelial cells. However, MM cells with downregulated SEP15 or the 1125A variant were somewhat less responsive to the growth inhibitory and apoptotic effects of selenium than MM cells expressing wild-type protein.RNAi-based knockdown studies demonstrated that SEP15 inhibition makes sensitive MM cells more resistant to selenium. These data imply that selenium may be useful as a chemopreventive agent in individuals at high risk of MM due to asbestos exposure, although those with the 1125A polymorphism may be less responsive to the protective benefits of dietary selenium supplementation.

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“…Gluthione-S-tranferases (GST) are a family of enzymes that detoxify reactive electrophiles such as epoxides (van Lieshout et al, 1998;Verhagen et al, 1997;Ketterer, 1998). A very common deletion in the GSTM1 and GSTT1 genes, creates a variant polymorphism that eliminates the respective enzyme activity in this detoxification enzyme system.…”

Section: Evidence Of Mechanism From Studies Of Vegetable Consumption mentioning

confidence: 99%

Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions

Alavanja

2002

Oncogene

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Effects of dietary anticarcinogens on rat gastrointestinal glutathione peroxidase activity.

Cited by 9 publications

References 29 publications

Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H₂O₂ Modulation and Cell Proliferation

Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H₂O₂ Modulation and Cell Proliferation

Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype

Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions

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Effects of dietary anticarcinogens on rat gastrointestinal glutathione peroxidase activity.

Cited by 9 publications

References 29 publications

Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H2O2 Modulation and Cell Proliferation

Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H2O2 Modulation and Cell Proliferation

Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype

Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions

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Product

Resources

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Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H₂O₂ Modulation and Cell Proliferation

Antioxidant Activity of Limonene on Normal Murine Lymphocytes: Relation to H₂O₂ Modulation and Cell Proliferation