Effects of dietary Astragalus polysaccharide and Astragalus membranaceus root supplementation on growth performance, rumen fermentation, immune responses, and antioxidant status of lambs

Zhong, Rongzhen; Yu, Mi Hee; Liu, H.W.; Sun, Haixuan; Cao, Yangchun; Zhou, Daowei

doi:10.1016/j.anifeedsci.2012.02.013

Cited by 74 publications

(73 citation statements)

References 37 publications

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“…Likewise, Zhong et al. () observed that dietary Astragalus polysaccharide supplementation improved antioxidant capacity but failed to improve growth performance of lambs.…”

Section: Discussionmentioning

confidence: 99%

“…During the intensive lamb fattening process, some factors such as weaning, high metabolic rates and transportation can induce oxidative stress, which may result in poor growth performance and increased susceptibility to disease (Celi, ). Recent studies reported that some herbs and their active components, such as polysaccharides and polyphenols, could be used to alleviate the negative effects of oxidative stress on fattening lambs due to their antioxidant properties (Kafantaris et al., ; Morán et al., ; Zhong et al., ). Among these phytocompounds, PEEU seems to be a potential candidate.…”

Section: Introductionmentioning

confidence: 99%

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Effects of polyphenolic extract from Eucommia ulmoides Oliver leaf on growth performance, digestibility, rumen fermentation and antioxidant status of fattening lambs

Liu

Zhao

et al. 2018

Animal Science Journal

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To investigate the effects of polyphenolic extract from Eucommia ulmoides Oliver leaf (PEEU) on growth performance, digestibility, rumen fermentation and antioxidant status of fattening lambs, 30 weaned male Huzhou lambs were equally divided into three treatments and fed the basal diet supplemented with 0 (CON), 5 (PEEU5) or 10 (PEEU10) g/kg PEEU. Dietary PEEU supplementation did not affect growth performance and apparent digestibility of nutrients. Compared with the CON group, lambs in the PEEU10 group had lower ammonia nitrogen concentration (p < .01) and acetic acid to propionic acid ratio (p < .05) and higher the molar proportion of propionate (p < .05) in rumen fluid. Ammonia nitrogen concentration (p < .01) and the molar proportion of propionate (p < .05) were affected by an interaction between PEEU and sampling day. Dietary PEEU supplementation at 10 g/kg increased total antioxidant capacity (p < .05), superoxide dismutase (p < .05) and glutathione peroxidase (p < .01) activities in serum and glutathione peroxidase activity (p < .05) in liver and decreased (p < .05) malondialdehyde content in serum and liver compared with the CON group. In conclusion, dietary PEEU supplementation affected rumen fermentation patterns and improved antioxidant status of fattening lambs.

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“…Likewise, Zhong et al. () observed that dietary Astragalus polysaccharide supplementation improved antioxidant capacity but failed to improve growth performance of lambs.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of polyphenolic extract from Eucommia ulmoides Oliver leaf on growth performance, digestibility, rumen fermentation and antioxidant status of fattening lambs

Liu

Zhao

et al. 2018

Animal Science Journal

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“…The rumen NH 3 -N is the most important source of N for microbial protein synthesis. Higher ruminal ammonia N concentrations indicate more rapid ruminal fermentation of proteins amination and/or reduced transport through the rumen wall (Zhong et al 2012). Based on our results, higher ammonia N concentrations in EW20 and EW30 may be mainly caused by a greater creep feed intake.…”

Section: Unweighted Unifrac Principal Coordinate Analysismentioning

confidence: 54%

Effect of weaning time on growth performance and rumendevelopment of Hu lambs

Chai

Diao

Wang

et al. 2016

IJAR

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This experiment was determined the effect of weaning time on growth performance, rumen fermentation, and microbial bacterial community of lambs. Forty eight Hu lambs were randomly divided into 4 treatments. Control lambs were ewe-reared (ER), while others were weaned at d 10, 20, or 30 after birth (EW10, EW20 and EW30) and fed milk replacer artificially until d 60. All lambs had ad libitum access to same creep feed from d 15 to 90. Results showed that average daily gain, creep feed intake, final body weight, hot carcass and rumen weight of EW10, EW20 and EW30 were greater (P less than 0.05) than ER. The ammonia N concentration of EW20 and EW30 was greater (P less than 0.05) than EW10 and ER. Butyric acid in EW10 and EW20 was greater (P less than 0.05) than EW30 and ER. The richness and biodiversity of bacterial communities had no difference (P > 0.05). The predominated rumen bacterial composition in phyla level had no difference, but the minor phyla present, Proteobacteria, had difference. These results demonstrated that weaning time could improve the growth performance and rumen weight and slightly affect rumen fermentation. Weaning at d 10 was recommended to farmer to maintain prior rumen development and performance in lambs.

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“…Kitagawa et al, 1983;Toda and Shirataki, 1999;Jeon et al, 2010). 특히 황 기 뿌리에는 glucan을 비롯한 이형다당류 (heteropolysaccharide) 와 astrogaloside I~IV의 사포닌 등이 풍부하게 존재하며 이들 다당류와 사포닌 성분의 면역조절 기능에 기인하여 근래에 약 물개발 분야에서 많은 관심을 받고 있다 (Zhong et al, 2012). 황기는 전통적으로 약용으로 사용되어온 지하부 뿐만 아니라 싹과 잎으로 구성되는 지상부에도 생리적 및 약리적 효능이 있는 것으로 여겨지는데 면역 활성이 감소한 mice에서 황기 잎과 줄기에 포함되어진 플라보노이드 성분이 LAK (lymphokine activated killer) 세포의 활성을 증대시키고 T cell을 활성화하여 면역능을 증가시킨다고 하였다 (Jiao et al, 1999).…”

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Isolation of Polysaccharides Modulating Intestinal Immune System and Single Oral Dose Toxicity Test in Astragalus membranaceus Abovegroud Parts

Choi¹,

Park²,

Lee³

et al. 2014

Korean Journal of Medicinal Crop Science

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: The six polysaccharide fractions were prepared by chromatographic procedure from the hot water extracts of the aboveground parts of Astragalus membranaceus. These six polysaccharides from aboveground parts of Astragalus membranaceus Bunge were tested for gut-mucosal immune activity and acute toxicity. In a view of molecular weight, the six fractions were estimated to be 75000, 88000, 129000 and 345000 Da, respectively. Component sugar analysis indicated that these fractions were mainly consisted of galactose (46.3~11.8%) and arabinose (35.4~9.9%) in addition to glucose, rhamnose, fucose, arabinose, xylose, mannose, glucuronic acid and galacturonic acid. Among the six major purified polysaccharides, AMA-1-b-PS2 showed highest bone merrow cell proliferation and lymphocyte of Peyer's patch stimulating activity. It may be concluded that intestinal immune system modulating activity of aboveground parts from Astragalus membranaceus Bunge is caused by polysaccharides having a polygalacturonan moiety with neutral sugars such as arabinose and galactose. In single oral dose toxicity study, no differences were observed between control and treated groups in clinical signs. The results indicated that lethal dose 50 (LD 50 ) of water extracts from Astragalus membranaceus-aboveground parts was found to be higher than 5000 ㎎/㎏/day in this experiment. From the above results, we may suggest that Astragalus membranaceus-aboveground parts might have useful as a safe material for functional food and pharmaceutics.

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Effects of dietary Astragalus polysaccharide and Astragalus membranaceus root supplementation on growth performance, rumen fermentation, immune responses, and antioxidant status of lambs

Cited by 74 publications

References 37 publications

Effects of polyphenolic extract from Eucommia ulmoides Oliver leaf on growth performance, digestibility, rumen fermentation and antioxidant status of fattening lambs

Effects of polyphenolic extract from Eucommia ulmoides Oliver leaf on growth performance, digestibility, rumen fermentation and antioxidant status of fattening lambs

Effect of weaning time on growth performance and rumendevelopment of Hu lambs

Isolation of Polysaccharides Modulating Intestinal Immune System and Single Oral Dose Toxicity Test in Astragalus membranaceus Abovegroud Parts

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