Effects of dietary cation-anion balance on acid-base status in horses

Plasma and urine electrolyte and mineral concentrations in Thoroughbred horses with recurrent exertional rhabdomyolysis after consumption of diets varying in cation-anion balance

“…Studies 48,49 in other species have indicated that a low dietary Ca 2+ content can induce a significant decrease in urinary Ca 2+ excretion. 12,20 In our study, the greater urinary excretion of Na + on the low diet, compared with the medium diet, might reflect the sequestration of a cation to accommodate increased Clexcretion. 49 Increased intestinal absorption of dietary Ca 2+ during metabolic acidosis is a significant contributing factor to the hypercalciuria observed in animals consuming an anionic diet but may not develop if the diet has a low Ca 2+ content or low Ca:P ratio.…”

“…12,16 The effect of DCAB on acid-base and electrolyte variables has been thoroughly investigated in dairy cattle, in which diets with low DCAB have been proven to significantly reduce the incidence of postparturient hypocalcemia via alterations in calcium metabolism. 20,21 One explanation for the predisposition of horses with RER to develop rhabdomyolysis while consuming a high grain diet may be associated with the effect of the diet on electrolyte, acid-base, and mineral balance, including ionized calcium. Cattle consuming diets with a low DCAB have high plasma 1,25 dihydroxyvitamin D concentrations, high plasma ionized calcium concentrations, and concurrent marked hypercalciuria.…”

Cyclical plasma electrolyte and acid–base responses to meal feeding in horses over a 24-h period

“…A post-feeding acidosis has been demonstrated previously; however, the results of the present study suggest that the time of day should be considered when interpreting equine feed studies. Stutz et al (1992) 7 [18][19][20], these were designed to determine the chronic effect of varying the DCAB on pH, and thus did not emphasize or discuss the significance of the acute [H þ ] responses to meal consumption. However, it appears that, although the chronic feeding of a low versus high DCAD diet resulted in a chronically higher plasma [H þ ], acutely the feeding of both low and high DCAD diets initially results in similar changes in…”

Effects of dietary cation-anion balance on acid base balance and blood parameters in anaerobically exercised horses

“…Kelso et al (1987) (MH) and +350 (H) mEq/kg DM. Like Topliff et al (1989), Baker et al, (1992) were true, then differences in blood flow through the muscle bed would be unlikely to affect the rate of efflux, implying that the difference in muscle lactate dissappearance rates between (S) and (T) recoveries resulted from differences in the rates of local utilization ie. glycogen synthesis and oxidation.…”

“…When prolonged, this condition could lead to an osteoporotic weakening of the skeletal system as seen in poultry {Hamilton and Thompson, 1980;Mongin, 1980;and Sauveur and Mongin, 1978). Baker et al (1992) in that horses consuming anionic diets tended to be acidotic while horses consuming cationic diets tended to be alkalotic at rest. Also, for blood acid-base parameters post anaerobic work, data in this trial tended to agree with Stutz et al (1992) and Milne (1974) as horses performing anaerobic work experienced an incompletely compensated metabolic acidosis.…”