Effects of Dietary Chrysin Supplementation on Blood Pressure and Oxidative Status of Rats Fed a High-Fat High-Sucrose Diet

Abstract

Effects of dietary chrysin supplementation on blood pressure and oxidative status of rats were studied in comparison with quercetin. Rats were fed a control diet or a high-fat high-sucrose (HFS) diet with or without 0.25% flavonoids (chrysin or quercetin) for 4 weeks. In rats fed the HFS diet without flavonoids, there was a significant elevation of blood pressure, increase in aortic NADPH oxidase but not xanthine oxidase, an increase in plasma lipid peroxides, and a decrease in liver glutathione, compared to rats fed the control diet. Chrysin suppressed the elevation of blood pressure in rats fed the HFS diets at the same level as quercetin. Chrysin supplementation did not suppress the increase in NADPH oxidase activity and plasma lipid peroxides or the decrease in liver glutathione, whereas these effects were significant with quercetin. Also, the results of an in vitro experiment suggested that chrysin did not exert antioxidative effects on lipid peroxidation in a linoleic acid emulsion. These results suggest that chrysin has an antihypertensive effect similar to quercetin, but unlike quercetin is not antioxidative in normotensive rats fed a HFS diet. Thus, it is probable that a mechanism(s) other than antioxidative activity is responsible for the suppression of hypertension by chrysin.

Multi‑omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin

“…It is present in propolis, honey, passion fruit, mushrooms and other plant sources; it has been used to treat numerous types of degenerative disorder and exhibits anti-inflammatory activity ( 34 - 36 ). In addition, it has been used in the treatment of numerous types of metabolic malfunction, such as metabolic syndrome ( 37 , 38 ).…”

In vitro and in vivo activities of flavonoids – apigenin, baicalin, chrysin, scutellarin – in regulation of hypertension – a review for their possible effects in pregnancy-induced hypertension

“…Moreover, chrysin was marked in herbs of Scutellaria galericulata L. [4], and Passilora caerulea L. [86,87]. Chrysin showed various pharmacological effects, such as anti-inflammatory [88], antioxidant [89], and antihypertensive activity [86,90,91,95], neuroprotective [86], anticancer properties [86], possessed protective effects against toxic agents [92], and many others [86].…”

“…administered to rats with hypertension caused by N-nitro-Larginine methyl ester showed antihypertensive effect throughout the following mechanism of action such as: reduction in functions of left ventricular, oxidative stress in cardiac tissue and level of angiotensin II in plasma, and increasing of hexooxygenase in cardiac tissue, concentration of cGMP and a prevention of plasma nitric oxide loss. Other study was carried out to estimation of effects of chrysin supplementation on blood pressure of rats fed a high-fat and highsucrose diet in comparison with quercetin [95]. Results showed that chrysin suppressed the elevation of blood pressure in normotensive rats and exerted an antihypertensive effect similar to quercetin.…”

Chrysin, but not flavone backbone, decreases anxiety-like behavior in animal screens

“…Chrysin is a natural flavonoid present in honey, propolis and diverse plant extracts (German-Ponciano et al, 2018), and is one of the most studied polyphenolic nutraceuticals (Chadha et al, 2017). Chrysin is used as a nutraceutical as a "testosterone boosting agent" (a claim that is probably very exaggerated; Gambelunghe et al, 2003), but there is some preclinical evidence that this molecule ameliorates indices of hepatic and renal functioning in diabetic animals (Ramanathan & Thekkumalai, 2014;Yamamoto, 2014). There is also preclinical evidence that this flavonoid exerts anxiolytic-like effects (Wolfman et al, 1994;Salgueiro et al, 1997;Zanoli et al, 2000;Rodríguez-Landa et al, 2019).…”