Effects of dietary equol administration on ovariectomy induced bone loss in Sprague–Dawley rats

Rachoń, Dominik; Seidlová-Wuttke, Dana; Vortherms, Tina; Wuttke, W.

doi:10.1016/j.maturitas.2007.09.005

Cited by 39 publications

(35 citation statements)

References 35 publications

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“…In the OVX+AP group, the percentage reduction of BMD in proximal tibia from baseline was -12.731%, indicating the AP protective effect, while in the cortical compartments of the total tibia the percentage reduction was -8.526%, similar to the non-treated OVX animals. The cortical bone rich regions which is included in the ROI measurements does not suffer such a dramatic loss in the early post OVX [19,20]. The mean percentage reduction of the proximal tibia BMD from baseline was greater for the OVX group in comparison to the OVX+AP group (-21.82% vs. -12.73%, p<0.001), demonstrating that AP plant is effective in preventing the onset of osteoporosis taking place during the first three months after ovariectomy.…”

Section: Discussionmentioning

confidence: 91%

“…Based on recent data, conducted by HPLC, eleven isoflavonoids were isolated from the methanol extract of the stem bark of AP [12]. Some of these isolated isoflavonoids such as daidzein, clycitein and formononetin have proven anabolic effect on bone metabolism and they prevent bone loss [20,32,[34][35][36][37]. A good correlation between the content of AP extract in isoflavones and its antioxidant activity has already been described [10,11] while the role of oxidative stress in the pathogenesis of osteroporosis is well established [38,39].…”

Section: Discussionmentioning

confidence: 99%

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The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Patsaki¹,

Tchoumtchoua²,

Passali³

et al. 2016

Med Aromat Plants

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Patsaki¹,

Tchoumtchoua²,

Passali³

et al. 2016

Med Aromat Plants

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“…That is, the odds ratio adjusted according to the ER· polymorphism showed that equol producers with the pp allele group had a decreased risk of OSI reduction. Not only did dietary equol administration to ovariectomized rats show limited bone sparing effects (12), but also long-term consumption of isoflavone-enriched foods did not affect bone metabolism in early postmenopausal women (28). However, these reports did not take ER· polymorphism into account.…”

Section: Discussionmentioning

confidence: 99%

“…Soy isoflavones, such as genistein, daidzein, and glycitein show estrogenic activity so they are also called phytoestrogens. In humans, equol is produced from daidzein in the gastrointestinal tract (12). Equol is structurally similar to 17ß-estradiol, which has an affinity for estrogen receptors so that it possesses estrogenic activity.…”

Section: Introductionmentioning

confidence: 99%

“…Equol is structurally similar to 17ß-estradiol, which has an affinity for estrogen receptors so that it possesses estrogenic activity. Dietary equol exerts mild estrogenic effects in the pituitary, uterus, mammary glands, liver and fat tissue, but shows limited bone sparing effects in ovariectomized rats (12). Moreover, the relationship between ER receptor polymorphisms and equol production and its effect on bone turnover is still uncertain.…”

Section: Introductionmentioning

confidence: 99%

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Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass

Katsuyama

Arii²,

Tomita³

et al. 2009

Int J Mol Med

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Abstract. To investigate the relationship between estrogen receptor polymorphisms and equol production and its effect on bone turnover, 139 workers (mean age 38.3±11.1 years) in Japan were recruited. Bone mineral density (BMD), bone turnover markers, and serum equol were measured at a health examination. DNA samples were prepared to detect the estrogen receptor · (ER·) polymorphism and were digested by PvuII. The number of equol producers was 57. No statistically significant differences were observed in bone mineral density and bone turnover markers between each ER· polymorphism and equol production. Since the adjusted odds ratio indicated that interaction itself decreased the risk of osteosonoassessment index (OSI) reduction using logistic regression analysis, further analysis was performed divided by each ER· polymorphism. Although the crude odds ratio showed no relationship between equol producers and non-producers, the adjusted odds ratio showed that equol producers with ER· pp had a significantly decreased risk of OSI reduction. Although this study was cross-sectional, both equol production and ER· polymorphism are closely associated with each other in relation to BMD.

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Clinical Chemistry in Toxicity Testing: Scope and Methods

Gosselin

Ramaiah

Earl

2009

General, Applied and Systems Toxicology

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Noncellular blood compartment (plasma or serum) and urine biochemical components are important indicators of overall animal health and can be used in conjunction with other parameters to investigate the toxicity of drugs and chemicals. This chapter describes the measurement and interpretation of clinical chemistry tests employed in toxicology studies in commonly used laboratory species. The introductory sections delineate methods for sample collection and data generation, and provide a general approach for data interpretation and reporting, with emphasis on distinguishing pre‐analytical/analytical variations from test material‐related changes. The following sections are organized by organ system, describing core clinical chemistry tests used in routine toxicology studies. These include protein, lipid and carbohydrate metabolisms, liver and kidney functions and electrolyte balance. Nonroutine tests evaluating cardiac and skeletal muscle, bone, blood vessels, the endocrine system, the nervous system are also presented. Because few clinical chemistry parameters are specific indicators of single organ toxicity, each section emphasizes the integrated interpretation of biochemistry changes with other study endpoints such as clinical signs, food consumption and bodyweight, haematology, electrocardiography, blood pressure and histopathology. Patterns of change are presented in the context of identifying organ toxicity.

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Effects of dietary equol administration on ovariectomy induced bone loss in Sprague–Dawley rats

Cited by 39 publications

References 35 publications

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass

Clinical Chemistry in Toxicity Testing: Scope and Methods

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