Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells

O’Prey, Jim; Brown, Judith; Fleming, Janis; Harrison, Paul R.

doi:10.1016/j.bcp.2003.07.007

Cited by 125 publications

(90 citation statements)

References 84 publications

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“…Studies of modulation of cell functions by polyphenols have been performed in different in vitro models such as cancer cells (56 -58) , epithelial cells (59,60) or skeletal cells. However, little is known regarding osteoblastic cells.…”

Section: Mechanisms Of Polyphenols In Osteoblastic Cellsmentioning

confidence: 99%

When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols

2009

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Recent research has provided insights into dietary components that may optimise bone health and stimulate bone formation. Fruit and vegetable intake, as well as grains and other plant-derived food, have been linked to decreased risk of major chronic diseases including osteoporosis. This effect has been partially attributed to the polyphenols found in these foods. Thus, it has been suggested that these compounds may provide desirable bone health benefits through an action on bone cell metabolism. The present review will focus on how some polyphenols can modulate osteoblast function and reports which cellular signalling pathways are potentially implicated. However, to date, despite numerous investigations, few studies have provided clear evidence that phenolic compounds can act on osteoblasts. Polyphenols cited in the present review seem to be able to modulate the expression of transcription factors such as runt-related transcription factor-2 (Runx2) and Osterix, NF-κB and activator protein-1 (AP-1). It appears that polyphenols may act on cellular signalling such as mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP), oestrogen receptor and osteoprotegerin/receptor activator of NF-κB ligand (OPG/RANKL) and thus may affect osteoblast functions. However, it is also important to take in account the possible interaction of these compounds on osteoclast metabolism to better understand the positive correlation reported between the consumption of fruit and vegetables and bone mass.

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Section: Mechanisms Of Polyphenols In Osteoblastic Cellsmentioning

confidence: 99%

When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols

2009

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“…In addition, other biological effects induced by flavonoids include lowering plasma levels of low-density lipoproteins, inhibiting platelet aggregation, and reducing cell proliferation (23,(25)(26)(27). These effects are related to their actions in inhibiting the cell cycle, diminishing oxidative stress, improving the efficacy of detoxification enzymes, inducing apoptosis, and stimulating the immune system (25)(26)(27). These inherent properties of flavonoids categorize them as a class of beneficial compounds which possess health-promoting and disease-preventing dietary effects, including efficacy in cancer prevention.…”

Section: Introductionmentioning

confidence: 99%

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

Patel

Shukla²,

Gupta³

2007

Int J Oncol

315

362

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Abstract. Cancer is one of the major public health burdens in the United States and in other developed countries, causing approximately 7 million deaths every year worldwide. Cancer rates vary dramatically in different regions and populations around the globe, especially between developing and developed nations. Changes in cancer prevalence patterns occur within regions as their populations age or become progressively urbanized. Migration has also contributed to such variations as changes in dietary habits influence cancer rates. These epidemiologic findings strongly suggest that cancer rates are influenced by environmental factors including diet, which is largely preventable. Approaches to prevent cancer include overlapping strategies viz. chemoprevention or dietary cancer prevention. Chemoprevention aims at prevention or reversal of the initiation phase of carcinogenesis or arrest at progression of carcinogenesis through the administration of naturally occurring constituents or pharmacological agents. Cancer prevention through diet may be largely achievable by increased consumption of fruits and vegetables. Considerable attention has been devoted to identifying plant-derived dietary agents which could be developed as promising chemopreventives. One such agent is apigenin. A naturally occurring plant flavone (4', 5, 7,-trihydroxyflavone) abundantly present in common fruits and vegetables including parsley, onions, oranges, tea, chamomile, wheat sprouts and some seasonings. Apigenin has been shown to possess remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. In the last few years, significant progress has been made in studying the biological effects of apigenin at cellular and molecular levels. This review examines the cancer chemopreventive effects of apigenin in an organ-specificity format, evaluating its limitations and its considerable potential for development as a cancer chemopreventive agent.

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“…[14][15][16][17][18][19][20] Plant extracts are a rich source of LO inhibitors 16,[21][22][23] and one particular class, the flavonoids, is relatively nontoxic, phenolic, and potent against LO. 16,[24][25][26][27] In addition, flavonoids have been shown to have antioxidant 24, 28 , anti-inflammatory 26,29 , antitumor 30 , antimicrobial 31 and antiviral properties 32 . One specific flavonoid LO inhibitor is baicalein, a major component in the root of Scutellaria baicalensis (1.9% of total root), and has been shown to induce apoptosis in breast, prostate, colon and pancreatic cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases

Deschamps

Kenyon

Holman

2006

Bioorganic & Medicinal Chemistry

144

125

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Abstract. Lipoxygenases (LO) have been implicated in asthma, immune disorders, and various cancers and as a consequence, there is great interest in isolating selective LO isozyme inhibitors.Currently, there is much use of baicalein as a selective human platelet 12-LO (12-hLO) inhibitor however, our current steady-state inhibition data indicates that baicalein is not selective against 12-hLO versus human reticulocyte 15-LO-1 (15-hLO-1) (15/12 = 1.3), in vitro. However, in the presence of detergents baicalein is slightly more selective (15/12 = 7), which may imply greater selectivity in a cell based assay but has yet to be proven. The mechanism of baicalein inhibition of 15-hLO is reductive, which computer docking suggests is through direct binding of the catecholic moiety of baicalein to the iron. A structurally related flavonoid, apigenin, is not reductive, however, computer docking suggests a hydrogen bond with Thr591, may account for its inhibitor potency.

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Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells

Cited by 125 publications

References 84 publications

When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols

When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases

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