Effects of dietary <i>Macleaya cordata</i> extract on growth performance, immune responses, antioxidant capacity, and intestinal development in weaned piglets

Chen, Jiashun; Kang, Baoju; Yao, Kang; Fu, Chenxing; Zhao, Yurong

doi:10.1080/09712119.2019.1636800

Cited by 30 publications

(27 citation statements)

References 65 publications

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“…In order to assess the antioxidant capacity of MCE, several antioxidant parameters such as T-AOC, SOD, GSH-Px, and MDA in serum were monitored. It has been reported that the T-AOC, GSH-Px, and SOD of serum increased in MCE-supplemented piglets ( Chen et al., 2019 ). GSH-Px is an important peroxidase that is widely present in the body, which catalyzes the reduction reaction of lipid peroxides caused by reduced glutathione to protect the cell membrane ( Johnson et al., 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Macleaya cordata extract on laying performance, egg quality, and serum indices in Xuefeng black-bone chicken

et al. 2021

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The abuse of antibiotic growth promoters ( AGPs ) in feed has led to drug resistance and ecological damage would threaten human health eventually. Natural plants have become a hotspot in the research and application of substituting AGPs because of their advantages of safety, efficiency, and availability. This study was conducted to investigate the effects of Macleaya cordata extract ( MCE ) in the diet of Xuefeng black-bone chicken on laying performance, egg quality, and serum indices. In this study, 576 birds (47-week-old) were evenly distributed between 4 treatments with 6 replicates of 24 hens each. The control group was fed a basal diet without MCE and the remaining groups received 100, 150, or 200 mg/kg MCE for 84 d. Results revealed that the strength and thickness of the eggshell increased significantly with the dietary addition of MCE ( P < 0.05). The serum concentrations of glutathione peroxidase increased in the MCE groups ( P < 0.01). Simultaneously, progesterone, follicle stimulating hormone, estradiol as well as serum luteinizing hormone levels also increased with the addition of MCE ( P < 0.05). Compared with the control group, supplementation of MCE significantly decreased the tumor necrosis factor-α and interleukin-6 levels ( P < 0.01). In summary, it was concluded that diet addition of 200 mg/kg MCE ameliorated egg quality, enhanced anti-oxidation and immune activity, and regulated hormone secretion of Xuefeng black-bone chicken.

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Section: Discussionmentioning

confidence: 99%

Effects of Macleaya cordata extract on laying performance, egg quality, and serum indices in Xuefeng black-bone chicken

et al. 2021

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“…cordata have antimicrobial and anti-inflammatory activities [ 8 ], it can potentially be used as a growth promoter. In fact, many previous studies have demonstrated the growth-stimulating effect of IQs in a variety of animal species including pigs [ 14 ], chickens [ 15 – 18 ], and fishes [ 19 – 21 ]. In line with these studies, our results revealed growth-enhancing effects of the four IQ-supplemented diets.…”

Section: Discussionmentioning

confidence: 99%

“…The potential health-promoting properties of IQ from M. cordata have been demonstrated in many animal species, including pigs [14], chickens [15][16][17][18], and fish [19][20][21][22]. These effects include growth performance enhancement, increased appetite, immunostimulation, alteration of the gut microbiome, and increased resistance to bacterial infection.…”

Section: Introductionmentioning

confidence: 99%

Effects of isoquinoline alkaloids from Macleaya cordata on growth performance, survival, immune response, and resistance to Vibrio parahaemolyticus infection of Pacific white shrimp (Litopenaeus vannamei)

et al. 2021

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Isoquinoline alkaloids (IQs) from Macleaya cordata are promising natural products for enhancing the growth performance and overall health condition of farmed animals. The present study aimed to investigate the effects of two formulas of IQ extract, provided in either a powdered formula (IQ-E) or a water-soluble, granulated formula (IQ-WS) and containing the main active component sanguinarine at a concentration of 0.5% and 1%, respectively, on the growth, survival, immune response, and resistance to Vibrio parahaemolyticus infection of Pacific white shrimp (Litopenaeus vannamei). In Experiment 1, the postlarvae were divided into five groups (four replicates/group and 100 shrimp/tank) and fed four times/day for 30 days with a control feed, IQ-E at 200 or 300 mg/kg of feed, or IQ-WS at 100 or 150 mg/kg of feed. In Experiment 2, the surviving shrimp from Experiment 1 were redistributed into six groups (four treatment groups as in Experiment 1 plus the positive and negative controls with four replicates/group and 30 shrimp/tank) and challenged with V. parahaemolyticus by immersion at a concentration of 103 colony-forming units (CFU)/mL and were fed with the same diets for another 14 days. The results revealed that all IQ-fed shrimp in Experiment 1 had significantly enhanced survival rates and immune parameters (total hemocyte count and phagocytic, phenoloxidase, and superoxide dismutase activities) compared to the control group, even though the growth performances were similar across all groups. In Experiment 2, all IQ-fed groups showed better growth performance and survival rates compared to the positive control. Other than in the positive control group, no histopathological lesions in the hepatopancreas and the intestine were found. In summary, the current study demonstrated the benefits of using IQs from M. cordata as feed additives for improving the growth performance, survival rate, immune responses, and resistance to vibriosis of Pacific white shrimp.

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“…The IQA formulation used is derived from Macleaya cordata , otherwise known as “plume poppy”, and is rich in IQA’s such as sanguinarine [ 21 ]. Extracts of Macleaya cordata have been shown to improve GIT health, as demonstrated by lowering diarrhea scores and Salmonella populations whilst promoting mucosal growth [ 17 , 20 , 32 ]. In a separate experiment, Macleaya cordata extracts reduced Salmonella , increased Lactobacillus populations, antioxidant capacity, parameters of immune function, small intestinal villus height, and growth performance [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Isoquinoline alkaloids inhibit cellular Na + /K + ATPases, which are important contributors to thermogenesis [ 18 , 19 ] and therefore may provide an approach to mitigate heat stress. Additionally, isoquinoline alkaloids have antioxidant [ 20 ] and anti-inflammatory properties [ 20 , 21 ] which may counteract oxidative stress, inflammation, and disruption of the GIT mucosa prevalent during HS. Thus, this experiment aimed to investigate whether the supplementation of isoquinoline alkaloids and betaine could ameliorate thermoregulatory responses and protect the intestinal integrity of grower pigs experiencing HS.…”

Section: Introductionmentioning

confidence: 99%

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Shakeri

Suleria

et al. 2020

Antioxidants

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Heat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory responses, particularly within the gastrointestinal tract. This study aimed to investigate whether plant-derived betaine and isoquinoline alkaloids could ameliorate HS in pigs. Fifty female Large White × Landrace grower pigs, which were acclimated to control (CON), control plus betaine (BET), or control plus isoquinoline alkaloids (IQA) diets for 14 days were then exposed to heat stress or thermoneutral condition. Both BET and IQA partially ameliorated increases in respiration rate (p = 0.013) and rectal temperature (p = 0.001) associated with HS conditions. Heat stress increased salivary cortisol concentrations and reduced plasma creatinine, lactate, and thyroid hormone concentrations. Heat stress increased colon FD4 permeability, which was reduced by IQA (p = 0.030). Heat stress increased inflammation in the jejunum and ileum, as indicated by elevated interleukin-1β (p = 0.022) in the jejunum and interleukin-1β (p = 0.004) and interleukin-8 (p = 0.001) in the ileum. No differences in plasma total antioxidant capacity (TAC) were observed with HS, but betaine increased plasma TAC compared to IQA. Dietary BET increased betaine concentrations in the jejunum, ileum (p < 0.001 for both), plasma, liver, kidney (p < 0.010 for all), urine (p = 0.002) and tended to be higher in muscle (p = 0.084). Betaine concentration was not influenced by HS, but it tended to be higher in plasma and accumulated in the liver. These data suggest that betaine and isoquinoline alkaloids supplementation ameliorated consequences of heat stress in grower pigs and protected against HS induced increases in colonic permeability.

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Effects of dietary Macleaya cordata extract on growth performance, immune responses, antioxidant capacity, and intestinal development in weaned piglets

Abstract: View related articles View Crossmark data Citing articles: 1 View citing articles Effects of dietary Macleaya cordata extract on growth performance, immune responses, antioxidant capacity, and intestinal development in weaned piglets

Cited by 30 publications

References 65 publications

Effects of Macleaya cordata extract on laying performance, egg quality, and serum indices in Xuefeng black-bone chicken

Effects of Macleaya cordata extract on laying performance, egg quality, and serum indices in Xuefeng black-bone chicken

Effects of isoquinoline alkaloids from Macleaya cordata on growth performance, survival, immune response, and resistance to Vibrio parahaemolyticus infection of Pacific white shrimp (Litopenaeus vannamei)

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

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