Effects of dietary lactose and lactase preparation on the intestinal absorption of calcium and magnesium in normal infants

Kobayashi, Akio; Kawai, Saburo; Y, Obe; Nagashima, Yoshiko

doi:10.1093/ajcn/28.7.681

Cited by 81 publications

(31 citation statements)

References 9 publications

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“…However, in the latter study, lactose and calcium were ingested as a bolus containing very high quantities (500 mg of Ca, 100 g of lactose). The present study is closer to those of Debongnie et al (1979) and Kobayashi et al (1975), both of which showed that hydrolysed lactose resulted in an increase in calcium absorption. However, the first one reported that hydrolysed lactose had a similar positive action in both control and lactase-deficient subjects, while we observed this effect only in the lactase-deficient ones.…”

supporting

confidence: 90%

Effect of lactose hydrolysis on calcium absorption during duodenal milk perfusion

Birlouez‐Aragon¹

1988

Reprod. Nutr. Dévelop.

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Summary. A multi-lumen intubation system was used to study the absorption of calcium, glucose and galactose in 13 human subjects. The intubation was placed between the duodenum abdomen and proximal jejunum and the subjects were perfused with milk and lactase-supplemented milk. Lactose disappearance over a 20 cm length of intestine was used as the index of lactase activity. The subjects were assigned to one of two groups, lactase-normal and lactase-deficient.There was linear correlation between the absorption of calcium and lactose :lactase-deficient subjects absorbed less calcium than lactase-normal subjects. Perfusion with lactase-supplemented milk enhanced calcium absorption in lactase-deficient subjects but had no effect on that of normal lactase subjects. All subjects absorbed approximately the same percentage of perfused calcium (24 %) when perfused with hydrolysed milk.These data indicate that the enhancement of calcium absorption is not a function of lactase per se, but of its hydrolytic products, glucose and galactose.Introduction.

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supporting

confidence: 90%

Effect of lactose hydrolysis on calcium absorption during duodenal milk perfusion

Birlouez‐Aragon¹

1988

Reprod. Nutr. Dévelop.

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“…Similar to the data from rodents, calcium absorption in neonates is enhanced by the lactose content of milk (317,318). Intestinal absorption and retention of calcium increase with both postnatal age and gestational age, with additional variations superimposed by the composition of the milk (45,221,256,485,604,613).…”

Section: Human Datasupporting

confidence: 69%

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Kovacs

2014

Physiological Reviews

211

188

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Mineral and bone metabolism are regulated differently in utero compared with the adult. The fetal kidneys, intestines, and skeleton are not dominant sources of mineral supply for the fetus. Instead, the placenta meets the fetal need for mineral by actively transporting calcium, phosphorus, and magnesium from the maternal circulation. These minerals are maintained in the fetal circulation at higher concentrations than in the mother and normal adult, and such high levels appear necessary for the developing skeleton to accrete a normal amount of mineral by term. Parathyroid hormone (PTH) and calcitriol circulate at low concentrations in the fetal circulation. Fetal bone development and the regulation of serum minerals are critically dependent on PTH and PTH-related protein, but not vitamin D/calcitriol, fibroblast growth factor-23, calcitonin, or the sex steroids. After birth, the serum calcium falls and phosphorus rises before gradually reaching adult values over the subsequent 24 -48 h. The intestines are the main source of mineral for the neonate, while the kidneys reabsorb mineral, and bone turnover contributes mineral to the circulation. This switch in the regulation of mineral homeostasis is triggered by loss of the placenta and a postnatal fall in serum calcium, and is followed in sequence by a rise in PTH and then an increase in calcitriol. Intestinal calcium absorption is initially a passive process facilitated by lactose, but later becomes active and calcitriol-dependent. However, calcitriol's role can be bypassed by increasing the calcium content of the diet, or by parenteral administration of calcium.

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“…Por exemplo, em estudo sobre o balanço de Ca em crianças de 8 meses de idade, utilizando-se três fórmulas infantis (uma padrão, uma livre de lactose e uma fórmula tratada com lactase), observou-se que a absorção do elemento foi de 60% para a fórmula padrão, de 36% para a lactose-livre, e de 72% para lactase tratada (31). Estes resultados, aparentemente contraditórios, sugerem que a glicose e a galactose liberada da hidrólise da lactose são igualmente eficientes na absorção do Ca alimentar (24,27).…”

Section: Lactoseunclassified

Biodisponibilidade do cálcio dietético

Buzinaro

Almeida

Mazeto

2006

Arq Bras Endocrinol Metab

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RESUMOO cálcio (Ca) dietético é fundamental para a saúde óssea. Tanto o teor como a biodisponibilidade do elemento nos alimentos devem ser considerados. Este artigo objetiva sumarizar os fatores envolvidos na absorção e destacar os alimentos com melhor disponibilidade do Ca. Este é absorvido principalmente no jejuno e o pH baixo parece favorecer sua absorção, que é maior no crescimento, na gestação/lactação e na carência de Ca ou fósforo (P), e menor no envelhecimento. As maiores fontes, e com melhor absorção, são os laticínios bovinos. Outros alimentos apresentam concentrações elevadas de Ca, mas com biodisponibilidade variável: os ricos em ácidos oxálico e fítico apresentariam uma menor absorção, enquanto que os ricos em carboidratos teriam uma absorção maior. Por apresentarem uma biodisponibilidade do Ca mais próxima da do leite bovino, o leite de outros animais, o de soja enriquecido e alguns vegetais, em quantidades adequadas, poderiam ser usados como alternativas a este. Dietary calcium (Ca) is fundamental to the bone's health. Both the purport and the element bioavailability in the food need to be considered. The purpose of this work was to summarize the factors involved in Ca absorption and point out the sources with higher bioavailability. Ca is mostly absorbed in the jejunum and low pH seems to favor its absorption, which is higher during growth, gestation/lactation and Ca and phosphorus (P) deficiency, and lower with aging. The richest and bestabsorbed Ca source is cow's milk and its derivatives. Other foods show high Ca concentrations but variable bioavailability: foods rich in phytates and oxalates show a smaller absorption and carbohydrate-rich foods show higher absorption. Since Ca bioavailability in other animal's milk, soymilk and some vegetables is closer to that in cow's milk, adequate amounts of these foods could be used as an alternative. O CRESCIMENTO E A MANUTENÇÃO do tecido ósseo dependem de uma grande variedade de fatores genéticos e ambientais. A hereditariedade contribui com cerca de 60 a 70% da expressão fenotípica da densidade mineral óssea (DMO), um dos mais importantes marcadores da saúde do osso. Por outro lado, fatores ambientais tais como dieta e estilo de vida revisãoBiodisponibilidade do Cálcio Dietético

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Effects of dietary lactose and lactase preparation on the intestinal absorption of calcium and magnesium in normal infants

Cited by 81 publications

References 9 publications

Effect of lactose hydrolysis on calcium absorption during duodenal milk perfusion

Effect of lactose hydrolysis on calcium absorption during duodenal milk perfusion

Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones

Biodisponibilidade do cálcio dietético

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