Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

Yamashita, Shinji; Sakurai, Riho; Hishiki, Kenshiro; Aida, Kazuhiko; Kinoshita, Mikio

doi:10.5650/jos.ess16169

Cited by 23 publications

(39 citation statements)

References 17 publications

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“…In this study, although the GlcCer content in plus RE diet was much less compared to the purified GlcCer content in the diet used in the previous study 1 g/kg diet 4 , dietary RE showed almost the same anti-ACF and anti-inflammatory effects. RE also contains small amounts of FA and T3, which are known to have anti-cancer and anti-inflammatory properties Table 1 19,20 .…”

Section: Discussioncontrasting

confidence: 54%

“…Our in vitro and in vivo studies indicate that GlcCer purified from food sources protects the colon epithelium from a variety of stressors DSS, DMH, LPS, and TNF-α 4,8,9 . Dietary RE suppressed the initial stages of inflammatory response Table 2 , and our results support this view.…”

Section: Discussionmentioning

confidence: 70%

“…2 . In our previous study performed on DMH-treated mice, we have shown that dietary GlcCer suppressed ACF formation and cytokine levels 4 . The patterns of cytokine suppression by RE in this study are very similar to those by GlcCer.…”

Section: Discussionmentioning

confidence: 88%

“…The present study suggests that the lipophilic fraction including GlcCer, present in polished rice has protective effects against intestinal impairment, but it requires extraction since digestion alone is not enough to elicit its complete protective action. production induced by 1,2-dimethylhydrazine DMH 4 . In vitro experiments indicate the possibility that GlcCer protects the colon surface from the harmful effects of various drugs 9 .…”

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confidence: 98%

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Extraction of Lipophilic Fraction from Polished Rice Improves Its Ameliorative Effect on Intestinal Impairment

et al. 2019

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Introduction Recently, the incidence rate of intestinal impairments, such as colon cancer and inflammatory bowel disease IBD , has increased in East Asian countries, including Japan, while that in the Western countries still remains high 1, 2. It is difficult to recover completely from IBD and these patients have an increased risk of developing colon cancer 3. In our previous research, we had suggested that the induction of inflammation-related cytokines has a connection with the formation of aberrant crypt foci ACF , which are precursors of colon cancer 4. Epidemiological studies indicate that colon cancer is strongly associated

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 98%

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Extraction of Lipophilic Fraction from Polished Rice Improves Its Ameliorative Effect on Intestinal Impairment

et al. 2019

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“…It is difficult to recover fully from IBD, and patients have an increased risk of developing colon cancer (3). Our previous research suggested that the production of inflammation-related cytokines has a connection with the formation of aberrant crypt foci (ACF), precursors of colon cancer (4). Epidemiological studies indicate that colon cancer is strongly associated with diet; thus, these inflammation-related diseases may be prevented through dietary changes and nutritional supplements (5).…”

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confidence: 99%

Chemical Properties and Nutritional Value of Plant-Origin Glucosylceramide

Yamashita

Kikuchi

Kinoshita

et al. 2019

J Nutr Sci Vitaminol

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Glucosylceramide (GlcCer), a representative sphingolipid in cell membranes of plants and fungi, is known to have certain benefits, such as prevention of intestinal impairment and improved skin moisturizing, when consumed. Recently, incidence rates of intestinal impairments have increased in East Asian countries due to changes of people's diet and life style. Therefore, the occurrence of these impairments needs to be prevented through dietary improvement and supplements containing GlcCer. The in vitro and in vivo effects of GlcCer on colon impairment were explored in our previous studies, with focus on sphingolipid structure. Conversely, plant cell membrane contents such as GlcCer are known to be difficult to extract due to the thick cell wall. Therefore, human and other mammals may not be able to utilize GlcCer when digesting food of plant origin. To confirm this hypothesis, we investigated the effects of polished rice and the extract on intestinal impairment. In addition, we discuss the intestinal function of GlcCer contained in polished rice and the relationship between GlcCer and other lipophilic functional components.

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Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH‐Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage

Nguma

Tominaga

Yamashita

et al. 2020

Lipids

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Ethanolamine plasmalogen (PlsEtn), a sub‐class of ethanolamine glycerophospholipids (EtnGpl), is a universal phospholipid in mammalian membranes. Several researchers are interested in the relationship between colon carcinogenesis and colon PlsEtn levels. Here, we evaluated the functional role of dietary purified EtnGpl from the ascidian muscle (87.3 mol% PlsEtn in EtnGpl) and porcine liver (7.2 mol% PlsEtn in EtnGpl) in 1,2‐dimethylhydrazine (DMH)‐induced aberrant crypt foci (ACF) in vivo, and elucidated the possible underlying mechanisms behind it. Dietary EtnGpl‐suppressed DMH‐induced aberrant crypt with one foci (AC1) and total ACF formation (P < 0.05). ACF suppression by dietary ascidian muscle EtnGpl was higher compared with dietary porcine liver EtnGpl. Additionally, dietary EtnGpl decreased DMH‐induced oxidative damage, overproduction of TNF‐α, and expression of apoptosis‐related proteins in the colon mucosa. The effect of dietary ascidian muscle EtnGpl showed superiority compared with dietary porcine liver EtnGpl. Our results demonstrate the mechanisms by which dietary PlsEtn suppress ACF formation and apoptosis. Dietary PlsEtn attained this suppression by reducing colon inflammation and oxidative stress hence a reduction in DMH‐induced intestinal impairment. These findings provide new insights about the functional role of dietary PlsEtn during colon carcinogenesis.

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Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

Cited by 23 publications

References 17 publications

Extraction of Lipophilic Fraction from Polished Rice Improves Its Ameliorative Effect on Intestinal Impairment

Extraction of Lipophilic Fraction from Polished Rice Improves Its Ameliorative Effect on Intestinal Impairment

Chemical Properties and Nutritional Value of Plant-Origin Glucosylceramide

Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH‐Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage

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