Effects of dietary saponins on fecal bile acids and neutral sterols, and availability of vitamins A and E in the chick

Jenkins, K. J.; Atwal, A. S.

doi:10.1016/0955-2863(94)90084-1

Cited by 113 publications

(73 citation statements)

References 13 publications

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“…However, plasma cholesterol level in the L-NAME+YSE treated rats was lower than in the L-NAME-treated and control rats. This result is in consistent with report that saponins are known to be hypocholesterolemic because of forming an insoluble complex with cholesterol, which prevents its absorption from the small intestine (15). Similarly, the L-NAME+YSE treated rats had significantly lower plasma glucose and total protein concentrations than the rats of control and L-NAME treated groups, as in agreement with previous results in chicks (15).…”

Section: Discussionsupporting

confidence: 82%

Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats

Nuray¹,

Bulbul²

2008

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The present study was aimed at investigating the effects of dietary supplementation of Yucca schidigera extract (YSE) on blood pressure, antioxidant activity and some biochemical parameters in the L-NAME-induced hypertensive rats. The study was performed on eighteen male Sprague-Dawley rats divided into 3 groups with 6 animals per group: 1) Control, fed standard chow ad libitum, 2) N-nitro-L-arginine methyl ester (L-NAME)-treated group, 75 mg/L drinking water, 3) YSE+L-NAME group, YSE (125 mg/kg diet)+L-NAME (75 mg/L drinking water), through study period lasted at 4 weeks. L-NAME-treated rats had significantly (P<0.05) higher the mean arterial blood pressure (MABP) as compared with the rats in the control and YSE+L-NAME groups. L-NAME+YSE-treated rats had lower heart rate (HR) as compared to the L-NAME-treated and control rats and, higher MABP as compared to the control rats. Plasma concentration of NO metabolites (NO x ) decreased after treatment with L-NAME. L-NAME+YSE-treatment increased the plasma malondialdehyde (MDA) and NOx concentration but decreased the antioxidant activity (AA), glucose, total cholesterol and total protein levels as compared to the other groups. The L-NAME-treatment decreased the vitamin A, but increased the beta-carotene and methemoglobin concentrations as compared to the other groups. In conclusion, these results may suggest that YSE ameliorates the increase of MABP in the L-NAME-induced hypertension by enhanced generation of vascular NO.Key words: Cholesterol, glucose, nitric oxide, vitamin A, yucca schidigera extract L-NAME ile hipertansiyon oluşturulmuş sıçanlarda diyete Yucca schidigera ekstraktı (YSE) ilavesinin kan basıncı, antioksidan aktivite ve bazı biyokimyasal parametreler üzerine etkisi Özet: Bu çalışmada, L-NAME ile hipertansiyon oluşturulmuş sıçanlarda diyete Yucca schidigera ekstraktı (YSE) ilavesinin kan basıncı, antioksidan aktivite (AA) ve bazı biyokimyasal parametreler üzerine etkileri araştırıldı. Araştırmada, 18 adet erkek Sprague-Dawley sıçan kullanıldı ve sıçanlar; 1) standart diyetle adlibutum beslenen kontrol grubu, 2) içme sularına günde 75 mg/L N-nitro-L-arginine methyl ester (L-NAME) uygulanan grup ve 3) içme sularında L-NAME alan grubun diyetine 125 ppm YSE uygulanan grup olmak üzere her biri 6 sıçandan oluşan üç gruba ayrıldı. Araştırma 4 hafta sonra sonlandırıldı. L-NAME uygulanan sıçanlarda ortalama arteriyel kan basıncı (OAKB) kontrol ve YSE+L-NAME gruplarına göre yüksek çıktı. Kalp atım sayısı ise YSE+L-NAME uygulanan sıçanlarda kontrol ve L-NAME grubuna göre düşük belirlendi. L-NAME uygulaması NO metabolitleri (NOx) ile vitamin A düzeyini azaltırken, β-karoten ve methemoglobin değerlerini artırdı. Sonuç olarak, L-NAME ile hipertansiyon oluşturulmuş sıçanların diyetine YSE ilavesinin NO oluşumunu artırarak ortalama arteriyel kan basıncını düzenleyebileceği düşünülmektedir.

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Section: Discussionsupporting

confidence: 82%

Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats

Nuray¹,

Bulbul²

2008

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Similarly, in laying hens, Heywang et al [34] obtained that adding 0.29 and 0.40% saponins from alfalfa to diets caused a reduction on feed intake and egg production without any effect on egg weight. In another study with growing chicks, Jenkins and Atwal [35] reported that supplementing different saponin sources with different amounts as 0.1% to 0.9%, they obtained that gypsophila saponins and quillaja saponins reduced growth ÇİFTÇİ, DALKILIÇ, ŞİMŞEK, AZMAN, ERİŞİR, ÖZÇELİK YILMAZ, İFLAZOĞLU MUTLU, TERLEMEZ, BAHŞİ performance and feed consumption but sarsaponin had no effect on same parameters. Whitehead et al [36] reported that the effect of supplementing saponin to diets on the performance of laying hens was dose dependent and no effects were seen with 0.1% saponin while negative effects were seen with 0.4-0.5% saponin on performance and liver lipid concentrations, and egg production rate.…”

Section: Discussionmentioning

confidence: 99%

“…Cheeke et al [37] reported that the depressed feed intake by the bitter taste of saponin is caused the negative effects on performance. Additionally, saponins has interaction with some vitamins and trace minerals such as zinc and this influences the metabolic and digestive enzymes [35,38,39] .…”

Section: Discussionmentioning

confidence: 99%

Soğuk Stresine Maruz Bırakılan Japon Bıldırcınlarında Diyete İlave Edilen Çöven Ekstraktının Yumurtlama Performansı, Kan Biyokimyasal Parametreleri, Göğüs Eti Yağ Asidi Profili İle Karaciğer ve Kalp Dokusu Antioksidatif Potansiyeli Üzerine Etkisi

Çiftçi¹,

Dalkiliç²,

Şimşek³

et al. 2016

Kafkas Univ Vet Fak Derg

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The purpose of this study was to evaluate the effects of dietary Soapwort Extract (SE) supplementation on laying performance, egg quality, some offal weights, some serum parameters, antioxidant status of liver and heart tissues and fatty acid composition of breast meat in chronic cold stressed Japanese quails. A total of sixty three 45-day-old Japanese quails were divided into three groups with three replicate. One group was fed with the corn-soybean based diet alone (control group) and the others were fed with the basal diet supplemented by 50 and 100 ppm SE. Cold stress was applied every night between 22.00 to 06.00 h as 7±1°C. SE supplementation had no significant effect on laying performance, offal weights and egg quality parameters with the exception of egg and albumen weights. Serum glucose, triglyceride, uric acid and aspartate aminotransferase (AST) levels were reduced in SE-50 group. While supplementation of 100 ppm SE decreased both liver and heart MDA levels, both amounts of SE increased the liver GSH-Px enzyme activity. Supplementation of 100 ppm SE decreased the levels of oleic acid and MUFA in breast meat, and it significantly increased the linoleic, linolenic and arachidonic acid, PUFA, total omega 6 and the ratio of omega 6/omega 3. It is displayed that SE supplementation to diets of laying quails exposed to cold stress can alleviate the detrimental effects of oxidative stress with no affecting on performance parameters. Keywords: Antioxidant, Cold stress, Fatty acid, Laying performance, Saponin, Soapwort extract Soğuk Stresine Maruz Bırakılan Japon Bıldırcınlarında Diyete İlave Edilen Çöven Ekstraktının Yumurtlama Performansı, Kan Biyokimyasal Parametreleri, Göğüs Eti Yağ Asidi Profili İle Karaciğer ve Kalp Dokusu Antioksidatif Potansiyeli Üzerine Etkisi ÖzetBu çalışmada, karma yeme ilave edilen çöven ekstraktının (SE), kronik soğuk stresine maruz bırakılan Japon bıldırcınlarında performans, yumurta kalitesi, bazı organ ağırlıkları, bazı serum parametreleri, karaciğer ve kalp dokularının antioksidan durumları ve göğüs eti yağ asidi profili üzerine etkileri araştırılmıştır. Toplam olarak 63 adet 45 günlük bıldırcın, 3 tekerrürlü 3 gruba ayrılmıştır. Gruplardan biri mısır-soya küspesine dayalı temel yem ile (kontrol grubu), diğer gruplar temel yeme 50 ve 100 ppm SE ilave edilen yemle beslenmişlerdir. Soğuk stresi her akşam 22.00-06.00 saatleri arasında kümes ısısı 7±1°C'ye düşürülerek uygulanmıştır. SE ilavesi performans, bazı organ ağırlıkları ile yumurta ve albümün ağırlığı hariç yumurta kalite parametrelerini etkilememiştir. Serum glikoz, trigliserit, ürik asit ve AST düzeyleri SE-50 grubunda düşmüştür. 100 ppm SE ilavesi karaciğer ve kalp dokularında MDA düzeylerini düşürürken, karaciğer GSH-Px enzim aktivitesi her iki SE grubunda artmıştır. 100 ppm SE ilavesi göğüs etinde oleik asit ve MUFA düzeylerini düşürürken, linoleik, linolenik ve araşidonik asit, PUFA, toplam omega 6 ile omega 6/omega 3 düzeylerini önemli ölçüde yükseltmiştir. Sonuç olarak; soğuğa maruz kalan yumurtacı bıldırcı...

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“…Subacute toxicity studies of the extract on body weight, feed consumption, water intake, liver function, kidney profile, haematological indices and histology of some vital organs were evaluated. The extract caused significant (p < 0.05) decrease in weight gain of rats which might be due to side effect of the extract, as studies have shown that dietary saponin depresses growth, feed consumption and egg production in poultry (Jenkins and Atwal, 1994). Other reports have ascribed such effects of saponins on reduced feed intake, to the astringent and irritating taste of saponins (Olezek et al, 1994), reduction in intestinal motility (Klita et al, 1996) and a reduction in protein digestion (Shimoyamada et al, 1998).…”

Section: Sub-acute Toxicological Assessmentmentioning

confidence: 99%

Sub-acute toxicity evaluation of ethanol extract of rheumatic tea formula (a polyherbal tea) in wistar rats

Aliyu¹,

Samaila²

2017

Bayero J. Pure App. Sci.

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Sub-acute toxicity profile of Rheumatic Tea Formula (RTF), a polyherbal tea consisting of Salix alba, Eucalyptus globulus and Albizia chevalieri was investigated in wistar rats of both sexes. Wistar rats were orally administered three different doses of ethanol extract of RTF for 28 days after which the effect on body weight, feed consumption, water intake, liver and kidney functions as well as haematological parameters were evaluated. Also evaluated was the histolopathogical effect of the extract on the liver, kidney, spleen and stomach. The extract significantly (p < 0.05) reduced body weight, feed consumption and water intake in rats. On liver function, there was no significant effect of Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST); however there was significant (p < 0.05) elevation of Alkaline Phosphatase (ALP). No significant effect (p > 0.05) on kidney function indices was observed. There was also no significant effect (p > 0.05) on haematological parameters, except for WBC differentials where there was significant (p < 0.05) elevation of lymphocytes and decrease in neutrophils. The extract was relatively non-toxic on kidney, liver, spleen, and stomach in the histopathological evaluations. The present study suggests that RTF extract might have no serious deleterious effect on sub-acute administration.

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Effects of dietary saponins on fecal bile acids and neutral sterols, and availability of vitamins A and E in the chick

Cited by 113 publications

References 13 publications

Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats

Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats

Soğuk Stresine Maruz Bırakılan Japon Bıldırcınlarında Diyete İlave Edilen Çöven Ekstraktının Yumurtlama Performansı, Kan Biyokimyasal Parametreleri, Göğüs Eti Yağ Asidi Profili İle Karaciğer ve Kalp Dokusu Antioksidatif Potansiyeli Üzerine Etkisi

Sub-acute toxicity evaluation of ethanol extract of rheumatic tea formula (a polyherbal tea) in wistar rats

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