Effects of dietary soybean isoflavones (SI) on reproduction in the young breeder rooster

Dai, Hancheng; Zhang, Tao; Tian, Ye; Yu, Shangyu; Liu, Wenbo; Xu, Kaili; Liu, Juan; Ding, Yu; Zhu, Beiwei; Yang, Yanzhou; Zhang, Cheng

doi:10.1016/j.anireprosci.2016.12.012

Cited by 17 publications

(15 citation statements)

References 41 publications

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“…Then, pregnenolone, a precursor for the synthesis of diverse steroids, moves to the smooth endoplasmic reticulum and is converted to dehydroepiandrosterone and then androstenedione by 3βHSD. The final conversion of androstenedione to testosterone is catalysed by 17βHSD [60]. In the current study, NDV infection significantly downregulated the expression of StAR, P450scc, and 3βHSD.…”

Section: Discussionsupporting

confidence: 55%

“…In the current study, NDV infection significantly downregulated the expression of StAR, P450scc, and 3βHSD. These results indicate that decreased mRNA expression of StAR, P450scc, and 3βHSD may have been the cause of decreased biosynthesis of hormones because the synthesis and levels of testosterone are closely associated with the expression of StAR, P450scc, and 3βHSD [58,60]. Steroid synthesis is regulated by steroidogenic factor-1 [61].…”

Section: Discussionmentioning

confidence: 84%

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Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters

Rehman

Ren

Yang

et al. 2020

Vet Res

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Newcastle disease (ND), which is caused by Newcastle disease virus (NDV), can cause heavy economic losses to the poultry industry worldwide. It is characterised by extensive pathologies of the digestive, respiratory, and nervous systems and can cause severe damage to the reproductive system of egg-laying hens. However, it is unknown whether NDV replicates in the male reproductive system of chickens and induces any pathologies. In this study, we selected a representative strain (i.e. ZJ1) of the most common genotype (i.e. VII) of NDV to investigate whether NDV can induce histological, hormonal, and inflammatory responses in the testes of specific pathogen free (SPF) roosters. NDV infection increased the expression of toll like receptor TLR3, TLR7, MDA5, IFN-α, IFN-β, IFN-γ, IL-8, and CXCLi1 in the testes of NDV-infected roosters at 5 days post-infection (dpi). Severe histological changes, including decrease in the number of Sertoli cells and individualized, shrunken spermatogonia with pyknotic nuclei, were observed at 3 dpi. At 5 dpi, the spermatogenic columns were disorganized, and there were fewer cells, which were replaced by necrotic cells, lipid vacuoles, and proteinaceous homogenous material. A significant decrease in the plasma concentrations of testosterone and luteinizing hormone (LH) and the mRNA expression of their receptors in the testes, steroidogenic acute regulatory protein, cytochrome P450 side-chain cleavage enzyme, and 3β-hydroxysteroid dehydrogenase in the NDVinfected group was observed relative to those in the control group (P < 0.05). Collectively, these results indicate that NDV infection induces a severe inflammatory response and histological changes, which decrease the steroidogenesis.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 84%

Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters

Rehman

Ren

Yang

et al. 2020

Vet Res

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“…Then, pregnenolone, a precursor for the synthesis of all steroid hormones, is converted to dehydroepiandrosterone and then androstenedione by 3b-HSD in the smooth endoplasmic reticulum. Finally, the conversion of androstenedione to testosterone is catalysed by 17b-HSD (Heng et al 2017). Steroidogenesis is under the strict control of LH.…”

Section: Discussionmentioning

confidence: 99%

D-Aspartate amends reproductive performance of aged roosters by changing gene expression and testicular histology

Ansari

Zhandi

Kohram

et al. 2018

Reprod. Fertil. Dev.

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Male broiler breeders (n = 32) of 55 weeks of age were administered four different doses of capsulated d-aspartate (DA; 0, 100, 200 or 300 mg kg−1 day−1, p.o. (DA0, DA100, DA200 and DA300 respectively)) for 12 successive weeks to assess reproductive performance, blood testosterone, testicular histology and transcript levels of steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme (P450scc), androgen receptor (AR), LH receptor (LHR), 3β-hydroxysteroid dehydrogenase (3BHSD), proliferating cell nuclear antigen (PCNA), glutamate ionotropic receptor NMDA type subunit 1 (GRIN1) and glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B). Blood samples and ejaculates were collected, and bodyweight was recorded weekly for 10 weeks. AI was performed weekly for the last 2 weeks to determine the number of sperm penetration holes in the perivitelline layer, fertility and hatchability. Testes histology and transcript levels were evaluated in the 12th week. Bodyweight, numbers of Leydig cells and blood vessels, testis index and levels of sperm abnormalities were not affected (P > 0.05) by the treatment. However, sperm total and forward motility, plasma membrane integrity and functionality of sperm, ejaculate volume, testosterone concentration and fertility were higher (P < 0.05) in both the DA200 and DA300 groups compared with the other groups. In the DA100 and DA200 groups, sperm concentration, number of spermatogonia, thickness of the seminiferous epithelium and the diameter of tubules were significantly higher (P < 0.05) than the other DA-treated groups. The number of penetration holes, hatchability and malondialdehyde concentration were higher in the DA200, all DA-treated and DA300 groups respectively compared with the control and other treatment groups. Except for P450scc, AR, LHR and PCNA transcript levels in the DA300 groups, the relative expression of the genes evaluated improved significantly in the other DA-treated groups. Based on these experimental findings, it is concluded that DA improves reproductive performance of aged roosters.

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“…Moreover, orally exposing to isoflavone at 600 mg/kg appears to be beneficial in increasing testicular weight, Sertoli cell area and seminiferous tubule volume [20]. In addition, the previous study revealed that GEN could significantly increase the expression of StAR, which accounts for the increment of spermatogonia number and germ cell layers [21].…”

Section: Introductionmentioning

confidence: 95%

“…Several lines of evidence have suggested that GEN exerts different effects on the male reproductive system, which depends on the dose and species [21,39]. However, whether there is a dosing limitation for predicting health risks remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Oral Exposure to Genistein during Conception and Lactation Period Affects the Testicular Development of Male Offspring Mice

Shi

et al. 2020

Animals

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Sexual hormones are essential for the process of spermatogenesis in the testis. However, the effect of maternal genistein (GEN) on the pups’ testicular development remain-unclear. Our present study evaluated the effects of supplementing GEN for parental and offspring mice on the reproductive function and growth performance of the male pups. Mothers during gestation and lactation period were assigned to a control diet (CON group), low dose GEN (LGE group) diet (control diet +40 mg/kg GEN), and high dose of GEN (HGE group) diet (control diet +800 mg/kg GEN). Their male offspring underwent the same treatment of GEN after weaning. LGE treatment (40 mg/kg GEN) significantly increased body weights (p < 0.001), testes weights (p < 0.05), diameters of seminiferous tubule (p < 0.001) and heights of seminiferous epithelium (p < 0.05) of offspring mice. LGE treatment also increased serum testosterone (T) levels and spermatogenesis scoring (p < 0.05). However, HGE treatment (800mg/kg GEN) significantly decreased body weights (p < 0.001), testes weights (p < 0.05) and testis sizes (p < 0.001). Furthermore, mRNA expressions of ESR2 (p < 0.05), CYP19A1 (p < 0.001), SOX9 (p < 0.001) and BRD7 (p < 0.001) in testis of mice were increased in the LGE group. Similarly, HGE treatment increased mRNA expressions of ESR2 (p < 0.05) and CYP19A1 (p < 0.001). However, mRNA expressions of SOX9 and BRD7 were decreased significantly in the HGE group (p < 0.001). Meanwhile, higher ratio apoptotic germ cells and abnormal sperms were detected in the HGE group (p < 0.001). In conclusion, exposure to a low dose of GEN during fetal and neonatal life could improve testicular development of offspring mice, whereas, unfavorable adverse effects were induced by a high dose of GEN.

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Effects of dietary soybean isoflavones (SI) on reproduction in the young breeder rooster

Cited by 17 publications

References 41 publications

Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters

Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters

D-Aspartate amends reproductive performance of aged roosters by changing gene expression and testicular histology

Oral Exposure to Genistein during Conception and Lactation Period Affects the Testicular Development of Male Offspring Mice

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