Effects of dietary supplementation of cumin (<i>Cuminum cyminum</i>L.) essential oil on expression of genes related to antioxidant, apoptosis, detoxification, and heat shock mechanism in heat-stressed broiler chickens

Yilmaz, Emre; Gül, Mehmet

doi:10.1080/10495398.2022.2117183

Cited by 3 publications

(3 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, numerous investigators reported the antioxidant efficacy of CCS extracts in separate trials (in vivo and in vitro), which were linked with their phytochemical profiles (terpenes, phenolic, and flavonoids). 19,51,52 The elevation of free radicles and increased rate of oxidative stress can generate a process called lipid peroxidation, which is a series of lipid degradation processes that can have a destructive effect on the cell organelles and can increase membrane permeability, altering collagen metabolism, proliferation of fibroblast, and easy access of keratinocyte. The lipid peroxidation in damaged skin tissues near can have inhibitory action on the production of endothelial growth factor (vascularization), causing further delay in wound contraction.…”

Section: Ccs Effects On Hydroxyprolyinementioning

confidence: 99%

“…The methanolic extracts of CCS showed significant radical quenching actions represented by lower SOD and CAT levels in rat's tissue homogenate, thereby reducing the rate of oxidative damage which can have a devastating effect on wounded tissues and the wound process of wound curing. Accordingly, numerous investigators reported the antioxidant efficacy of CCS extracts in separate trials (in vivo and in vitro), which were linked with their phytochemical profiles (terpenes, phenolic, and flavonoids) 19,51,52 …”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

Ahmed,

Jabbar,

Galali

et al. 2024

Skin Research and Technology

View full text Add to dashboard Cite

Wound healing is a complex, intricate, and dynamic process that requires effective therapeutic management. The current study evaluates the wound healing potentials of methanolic extract of Cuminum cyminum L. seeds (CCS) in rats. Sprague Dawley (24) rats were distributed into four cages, wounds produced on the back of the neck, and received two daily topical treatments for 14 days: A, rats received normal saline; B, wounded rats treated with intrasite gel; C and D, rats received 0.2 mL of 250 and 500 mg/kg of CCS, respectively. After that, wound area and closure percentage were evaluated, and wound tissues were dissected for histopathological, immunohistochemical, and biochemical examinations. Acute toxicity trials of methanolic extract of CCS showed the absence of any physiological changes or mortality in rats. CCS application caused a significant reduction in wound size and a statistically elevated percentage of wound contraction than those of vehicle rats. CCS treatment caused significant up‐regulation of collagen fiber, fibroblasts, and fewer inflammatory cells (inflammation) in granulation tissues. TGF‐β1 (angiogenetic factor) was significantly more expressed in CCS‐treated rats in comparison to normal saline‐treated rats; therefore, more fibroblasts transformed into myofibroblasts (angiogenesis). CCS‐treated rats showed remarkable antioxidant potentials (higher SOD and CAT enzymes) and decreased MDA (lipid peroxidation) levels in their wound tissue homogenates. Hydroxyproline amino acid (collagen) was significantly up‐regulated by CCS treatment, which is commonly related to faster wound closure area. The outcomes suggest CCS as a viable new source of pharmaceuticals for wound treatment.

show abstract

Section: Ccs Effects On Hydroxyprolyinementioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

Ahmed,

Jabbar,

Galali

et al. 2024

Skin Research and Technology

View full text Add to dashboard Cite

show abstract

Role of the antioxidant defence system and transcription factors in preventing heat stress in poultry: a dietary approach

Şahin

Deeh

et al. 2023

World's Poultry Science Journal

View full text Add to dashboard Cite

Effects of essential oils on heat‐stressed poultry: A review

Yilmaz,

Gul

2024

Animal Physiology Nutrition

View full text Add to dashboard Cite

While certain animal species are sensitive to heat stress, poultry particularly modern breeds, are more susceptible to high ambient temperatures. This has major implications for the poultry industry, as heat stress causes large financial losses. These economic losses will probably increase as a consequence of a predicted rise in global temperatures. Heat stress adversely affects various aspects of poultry, including physiological responses, growth and production performance, meat quality, egg quality, and reproductive activities. These effects occur through specific molecular and metabolic pathways. To mitigate the impacts of heat stress, it is crucial to go beyond administrative practices and implement dietary interventions during high ambient temperature. Such interventions aim to optimize the development of stressed bird species in terms of performance, health, and profitability. Essential oils have shown promising in mitigating the negative effects of heat stress and improved antioxidant status, growth and yield performance, as well as meat and egg quality in poultry. They actively participate in certain metabolic and molecular pathways that help to counteract the effects of heat stress. The article discusses the impacts of essential oil supplementation on the relationships between antioxidant enzyme activity, these molecular, and metabolic pathways, as well as various parameters such as growth and yield performance, and product quality heat‐stressed poultry.

show abstract

Effects of dietary supplementation of cumin (Cuminum cyminumL.) essential oil on expression of genes related to antioxidant, apoptosis, detoxification, and heat shock mechanism in heat-stressed broiler chickens

Cited by 3 publications

References 61 publications

Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

Role of the antioxidant defence system and transcription factors in preventing heat stress in poultry: a dietary approach

Effects of essential oils on heat‐stressed poultry: A review

Contact Info

Product

Resources

About