Effects of dietary supplementation with antimicrobial peptide‐P5 on growth performance, apparent total tract digestibility, faecal and intestinal microflora and intestinal morphology of weanling pigs

Abstract

The results obtained in this study indicate that dietary supplementation with 60 mg kg(-1) AMP-P5 has the potential to improve the growth performance and apparent total tract digestibility of nutrients and reduce coliforms in weanling pigs.

Insect proteins as a potential source of antimicrobial peptides in livestock production. A review

“…Moreover, increasing levels of dietary AMP linearly improved the overall average daily gain and the total tract apparent digestibility of crude protein, dry matter and gross energy (Yoon et al, 2012(Yoon et al, , 2014. Similar effects for AMP-P5 were obtained following supplementation of piglet diets (Yoon et al, 2013). The authors suggest that AMP-P5 at dietary concentrations of 60 mg · kg −1 may be used as a novel alternative to antibiotic growth promoters.…”

“…Research on the effect of AMPs as dietary supplements in animal production has been conducted mainly on pigs (Tang et al, 2009(Tang et al, , 2012Yoon et al, 2012Yoon et al, , 2013Yoon et al, , 2014Wu et al, 2012;Xiong et al, 2014). The analysed AMPs were, among others: antimicrobial peptide-A3 (AMP-A3), antimicrobial peptide-P5 (AMP-P5), antimicrobial peptide cecropin AD, lactoferrins (cipB-lactoferricin-lactoferrampin, recombinant lactoferrampinlactoferricin), and the mixture of lactoferrin, cecropin, defensin and plectasin.…”

“…In those researches the doses of single AMPs ranged from 40 mg · kg . The studies conducted by Yoon et al (2012Yoon et al ( , 2013Yoon et al ( , 2014 on the dietary supplementation of AMPs showed that both AMP-A3 and AMP-P5 (synthetic analogues of hybrid cecropin-magainin) have a positive effect on growth performance, faecal microbiota and intestinal morphology of weanling piglets. Cecropin is a type of antibacterial peptide identified in many insect species, while magainins are a class of antimicrobial peptides found in the African clawed frog (Xenopus laevis).…”

“…Cecropin is a type of antibacterial peptide identified in many insect species, while magainins are a class of antimicrobial peptides found in the African clawed frog (Xenopus laevis). In the studies of Yoon et al (2012Yoon et al ( , 2013Yoon et al ( , 2014, the basal diet was supplemented with 60 and 90 mg of AMP-A3 or 40 and 60 mg of AMP-P5 per kg of diet. The authors showed that the total number of anaerobic bacteria declined (P < 0.05) linearly with increasing levels of either AMP-A3 or AMP-P5 in the diets.…”

“…The use of AMPs may be a promising alternative to antibiotics Xiao et al, 2013aXiao et al, ,b, 2015aYoon et al, 2013Yoon et al, , 2014Yi et al, 2014;Wang et al, 2016). The interest in insect AMPs is based on the knowledge from ancient times, where different insects were used in the treatment of a number of different ailments (Table 1).…”